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Digitale Medien

Paradoxical glucagon response after stimulation with glucose and arginine in isolated pancreatic sand rat islets (1975)

Ziegler, M. ; Hahn, H. -J. ; Ziegler, B. ; [weitere]

Springer

Diabetologia 11 (1975), S. 63-69

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Details

ISSN: 1432-0428

Schlagwort(e): Pancreatic islets ; insulin secretion ; insulin content ; glucagon secretion ; glucagon content ; wistar rats ; sand rats ; glucose ; arginine

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00422820

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