ISSN:
1432-0428
Keywords:
Protein denaturation
;
insulin stability
;
automatic delivery devices
;
insulin therapy
;
polypropylene glycol/polyethylene glycol block polymers
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Studies with insulin delivery devices have shown that denaturation of dissolved proteins at hydrophobic interfaces is a basic obstacle to long-term insulin stability in pumps. This study shows that polypropylene glycol/polyethylene glycol block polymers prevent both the adsorption of dissolved proteins to hydrophobic interfaces and the resultant aggregation. At a concentration of 0.001% (w/v), the block polymer Genapol PF-10 stabilises insulin solutions over a wide range of concentrations. Insulin solutions thus stabilised are at present being clinically tested. The effectiveness of molecular variants of Genapol PF-10 to stabilise other proteins (human γ-globulin, myoglobin and serum albumin) is presented also.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00273809
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