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  • 1
    Electronic Resource
    Electronic Resource
    Measurements ofn−p correlations in the reaction of relativistic neon with uranium (1986)
    Springer
    The European physical journal 323 (1986), S. 391-398 
    Details
    ISSN: 1434-601X
    Keywords: 25.70.Np
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report a preliminary measurement of coincident neutron-proton pairs emitted at 45° in the interaction of 400, 530, and 650 MeV/A neon beams incident on uranium. Charged particles were identified by time of flight and momentum, as determined in a magnetic spectrometer. Neutral particles were detected using a thick plastic scintillator, and their time of flight was measured between an entrance scintillator, triggered by a charged particle, and the neutron detector. The scatter plots and contour plots of neutron momentum vs. proton momentum appear to show a slight correlation ridge above an uncorrelated background. The projections of this plane on then-p momentum difference axis are essentially flat, showing a one standard deviation enhancement for each of the three beams energies. At each beam energy, the calculated momentum correlation function for the neutron-proton pairs is enhanced near zero neutron-proton momentum difference by approximately one standard deviation over the expected value for no correlation. This enhancement is expected to occur as a consequence of the attractive final state interaction between the neutron and proton (i.e., virtual or “singlet” deuterons). The implications of these measurements are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01313520
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    New strategies in marrow purging for breast cancer patients receiving high-dose chemotherapy with autologous bone marrow transplantation (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. S19 
    Details
    ISSN: 1573-7217
    Keywords: amifostine ; autologous bone marrow transplantation (ABMT) ; breast cancer ; 4-hydroperoxycyclophoshamide (4-HC) ; marrow purging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary High-dose chemotherapy and autologous bone marrow transplantation (ABMT) are commonly used to treat selected patients with high-risk breast cancer. A limitation of ABMT is that clonogenic cancer cells could be collected with the bone marrow and produce a relapse of disease when reinfused into patients. Purging the marrowex vivo may eliminate the tumor cells, but it can also delay engraftment. We employed two different purging methods whereby breast cancer cells were depleted without delaying engraftment. The addition of WR-2721 (amifostine) to 4-hydroperoxycyclophosphamide (4-HC) reduced the time to engraftment by 10 days compared with marrow purged with 4-HC alone (26 versus 37 days, respectively). The positive selection of CD34+ hematopoietic progenitors produced engraftment within 21 days. The use of granulocyte colony-stimulating factor (G-CSF) accelerated the engraftment time of CD34+ hematopoietic progenitors to 11 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00668356
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetic/pharmacodynamic interactions of intensive cyclophosphamide, cisplatin, and BCNU in patients with breast cancer (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. S11 
    Details
    ISSN: 1573-7217
    Keywords: autologous hematopoietic cell support ; BCNU ; breast cancer ; carboplatin ; cisplatin ; cyclophosphamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Combinations of alkylating agents in intensive doses with autologous hematopoietic cell support (AHCS) are commonly used to treat advanced, solid tumors. Relatively little is known about the pharmacokinetic or pharmacodynamic aspects of their use. The cyclophosphamide, cisplatin, and BCNU (CPA/cDDP/BCNU) regimen is often used in patients with breast cancer. In these individuals, the blood levels of BCNU vary by more than tenfold. In rats given BCNU, the blood level variability is associated with cisplatin pretreatment, and mean levels are much higher than those that occur when cisplatin pretreatment is omitted. These observations suggest that a major elimination pathway for BCNU is metabolic and is subject to cisplatin disruption. Between 30–50% of patients receiving the CPA/cDDP/BCNU regimen experience a steroid-responsive pulmonary injury that can be fatal if untreated. Blood levels of BCNU are positively correlated with the risk of pulmonary injury in these patients. Others have demonstrated that blood levels of CPA can be inversely correlated with the likelihood of cardiac toxicity and 2-year, relapse-free survival in patients with breast cancer. Emerging data suggest that circulating drug levels, rather than the calculated dose, best explain the variability of outcome in patients treated with combination alkylating agents and AHCS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00668355
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    Paper (German National Licenses)
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