ISSN:
1573-7446
Keywords:
buffalo
;
disposition
;
dose
;
kanamycin
;
pharmacokinetics
;
serum
;
urine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The disposition kinetics and appropriate dosage regimen for kanamycin were investigated in buffalo calves following a single intravenous dose of 10 mg/kg body weight. The distribution and elimination half-lives were 0.12±0.01 h and 1.94±0.11 h, respectively. The apparent volume of distribution and total body clearance were 0.2±0.01 L/kg and 92.9±3.69 ml/kg/h, respectively. About 74% of the administered dose was excreted in urine in 24 h. A suitable dosage regimen for the intravenous administration of kanamycin was also calculated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01839170
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