ISSN:
1573-8221
Keywords:
ceruloplasmin
;
ceruloplasmin receptor
;
copper transport
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract It is shown that cultured cells of the CV-1 line possess the capacity for high-affinity binding of ceruloplasmin, show a kinetics of saturation, and internalize ceruloplasmin. Propagation of cells in medium supplemented with fetal calf serum depleted of ceruloplasmin results in a two-fold increase of high-affinity receptor expression on the cell surface. This phenomenon is not accompanied by any change in the receptor-ligand affinity. Ceruloplasmin binding to the cell surface and subsequent internalization do not lead to its marked degradation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445905
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