ISSN:
1432-1041
Schlagwort(e):
chlorpromazine
;
sperm motility
;
central nervous system depressant
;
caffeine
;
membrane stabilizing effect
;
fertility
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The in vitro effects of chlorpromazine, diazepam, phenytoin and phenobarbitone on human sperm motility were investigated. Only chlorpromazine inhibits human sperm motility and the concentration which decreases sperm motility to 50% of control is 0.22 mM. Caffeine can shift the dose-response curve of chlorpromazine-inhibited sperm motility to right. We support the hypothesis that chlorpromazine acts on the cellular membrane but consider the inhibition of sperm motility an unlikely cause of decreased fertility in chlorpromazine treated patients.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00542545
Permalink