ISSN:
1435-1463
Schlagwort(e):
Autoradiography
;
choline acetyltransferase
;
kappa receptors
;
Alzheimer brain
;
presynaptic
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The binding of [3H]-U-69593 and [3H]-CI-997 to kappa-1 opioid receptors has been examined in the temporal cortex of postmortem brains from patients with Alzheimer's disease and age-matched controls using quantitative autoradiography. There was no significant difference between Alzheimer and control subjects in the level of [3H]-U-69593 and [3H]-CI-977 binding, but ChAT activity was markedly reduced (by 73% compared to controls). These results are not consistent with a presynaptic localisation of kappa-1 receptors on cholinergic terminals in human temporal cortex.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02252664
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