ISSN:
1435-1463
Keywords:
Post mortem
;
3H-acetylcholine
;
release
;
physostigmine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A technique was developed, which made it possible to study thein vitro release of3H-acetylcholine (3H-ACh) from human post mortem brain tissue, collected with short post-mortem delay (2,5–22 hours), both from controls and patients with Alzheimer's disease (AD/SDAT). The tritium (3H) release was investigated during potassium stimulation, and AD/SDAT cortical slices were found to release a decreased amount of3H compared to control brain slices. Physostigmine, 10−5 and 10−4 M, has no significant effect on the release of3H from control slices, while physostigmine 10−4 M increased the evoked release from AD/SDAT brain slices over threefold, nearly to the control level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01243353
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