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  • 1
    Digitale Medien
    Digitale Medien
    Competitive and noncompetitive NMDA antagonists block sensitization to methamphetamine
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 48 (1994), S. 587-591 
    Details
    ISSN: 0091-3057
    Schlagwort(e): Behavioral sensitization ; D-CPP-ene Glutamate ; MK-801 ; Methamphetamine ; N-methyl-D-aspartate ; Tolerance
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/0091-3057(94)90318-2
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  • 2
    Digitale Medien
    Digitale Medien
    Scopolamine prevents augmentation of stereotypy induced by chronic methamphetamine treatment (1995)
    Springer
    Psychopharmacology 121 (1995), S. 158-163 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Methamphetamine ; Behavioral sensitization ; Scopolamine ; Acetylcholine ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether scopolamine, a muscarinic cholinergic antagonist, would also block augmentation of stereotypy induced by chronic methamphetamine (MA) treatment. Rats treated with MA (2.5 mg/kg, SC) for 10 days indicated significantly enhanced stereotyped behavior when tested with MA (2.5 mg/kg) after a 7-to 8- day withdrawal. Pretreatment with scopolamine (3 mg/kg) prior to MA administration prevented the augmentation of stereotypy. Rats treated with scopolamine alone showed no difference in MA-induced stereotypy compared to those treated with saline. Scopolamine methylbromide, a derivative of scopolamine that does not easily cross the blood-brain barrier, had no effect on the augmentation of stereotypy. These results suggest that stimulation of central muscarinic cholinergic receptors plays a role in the development of sensitization to the stereotypy stimulating effect of methamphetamine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02245625
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  • 3
    Digitale Medien
    Digitale Medien
    Effects of nitric oxide synthesis inhibition on methamphetamine-induced dopaminergic and serotonergic neurotoxicity in the rat brain (1996)
    Springer
    Journal of neural transmission 103 (1996), S. 671-680 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Nitric oxide (NO·) ; methamphetamine ; neurotoxicity ; dopamine ; serotonin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We examined effects of nitric oxide (NO·) synthesis inhibition on methamphetamine (MA)-induced dopaminergic and serotonergic neurotoxicity. The toxic dose of MA (5 mg/kg, sc, X4) significantly decreased contents of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum (ST), and significantly decreased contents of serotonin (5-HT) in the ST, nucleus accumbens (NA) and medial frontal contex (MFC). Coadministration with a NO· synthase inhibitor, Nω-nitro-L-arginine methyl ester (LNAME) (30 mg/kg, ip, X2), reduced the MA-induced decreases in contents of DA, DOPAC and HVA in the ST, but not reduced the MA-induced decreases in contents of 5-HT in the ST, NA and MFC. These findings suggest that the MA-induced dopaminergic, but not serotonergic neurotoxicity, may be related to the neural process such as NO· formation caused by the activation of postsynaptic DA receptor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01271227
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  • 4
    Digitale Medien
    Digitale Medien
    Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions (1993)
    Springer
    Journal of neural transmission 92 (1993), S. 97-106 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Methamphetamine ; neurotoxicity ; N-methyl-D-aspartate ; dopamine ; serotonin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Protective effects of NMDA antagonists on dopaminergic and serotonergic neurotoxicity produced by methamphetamine (MA) were examined. Four injections of MA (7.5 mg/kg, s.c., at 2 h intervals) caused significant decrements (40–60% of control values) in levels of dopamine (DA) and its metabolites in the rat striatum and levels of serotonin (5-HT) and its metabolite in the medial prefrontal cortex, nucleus accumbens, striatum, anterior hypothalamus, amygdala and hippocampus. These decreases in DA, 5-HT and their metabolites were prevented by pretreatment with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, or D-CPP-ene (SDZ EAA 494), a competitive NMDA antagonist. The results suggest that NMDA receptors play a role for MA-induced serotonergic damage in various brain regions as well as dopaminergic damage in the striatum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01244869
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  • 5
    Digitale Medien
    Digitale Medien
    Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat (1987)
    Springer
    Journal of neural transmission 68 (1987), S. 227-240 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Neuroleptics ; dopamine ; prolactin ; hypothalamus ; clozapine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Two atypical neuroleptic agents, clozapine and fluperlapine, produced rapid elevations in plasma PRL concentrations that were similar in magnitude to those produced by haloperidol. However, the PRL response to clozapine or fluperlapine was of much shorter duration than that elicited by haloperidol. Clozapine, but neither fluperlapine nor haloperidol, produced a rapid increase in the activity of tuberoinfundibular dopamine (TIDA) neurons, as evidenced by an enhanced accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after the inhibition of DOPA decarboxylase. The clozapine-induced increase in DOPA accumulation was evident within 30 minutes after its administration and persisted for at least 4 hours. The clozapine-induced increase in the activity of TIDA neurons may account, in part, for the abbreviated PRL response to this neuroleptic. In addition, ability to produce a short-lived increase in PRL secretion in the rat appears to be common to the atypicl neuroleptic drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02098500
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