ISSN:
1420-9071
Keywords:
Adenylate cyclase
;
cytochrome P-450
;
ecdysone 20-monooxygenase
;
forskolin
;
steroid hydroxylase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The adenylate cyclase activator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin were found to inhibit in a dose-dependent fashion the ecdysone 20-monooxygenase activity associated with wandering stage larvae ofDrosophila melanogaster and fat body and midgut from last instar larvae of the tobacco hornworm,Manduca sexta. The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5×10−6 to 5×10−4 M.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01923603
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