ISSN:
1573-2568
Keywords:
gastric emptying
;
fatty meal
;
cisapride rectally
;
acceleration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The evaluation of agents potentially accelerating gastric emptying in gastric stasis syndromes is time-consuming. Since a previous study showed that emptying is slowed after antecedent fat ingestion and intravenous cisapride abolishes this effect, we investigated whether emptying delayed by fat incorporated into a meal is reversed by cisapride and thus could serve as a model for such evaluations. Twelve healthy males received, under double-blind conditions, 30 mg cisapride rectally or placebo, and 3 hr thereafter a semisolid meal of low (9.2 g) or high (37.9 g) fat content. The sequence of combinations placebo/low-fat meal, placebo/high-fat meal, and cisapride/high-fat meal was randomized. Gastric emptying and antral motility were recorded scintigraphically. After placebo/high-fat, emptying was significantly slower (P〈0.05) than after placebo/low-fat. After cisapride/high-fat, emptying was significantly faster (P〈0.01) than after placebo/high-fat and similar to that after placebo/low-fat. Antral motility was little affected. The slow emptying of a high-fat meal thus seems a suitable model for the evaluation of prokinetic drug effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01307519
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