ISSN:
1420-9071
Keywords:
Hypovolemic shock
;
hemorrhage
;
dimethylphenylpiperazinium
;
resuscitation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition-without the need for reinfusion of the shed blood-starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02118314
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