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  • hepatic monooxygenases  (1)
  • pharmacokinetics  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of antipyrine in rats with different resistance to hypoxia in cold stress (1998)
    Springer
    Bulletin of experimental biology and medicine 126 (1998), S. 1098-1099 
    Details
    ISSN: 1573-8221
    Schlagwort(e): pharmacokinetics ; antipyrine ; individual resistance to hypoxia ; cold stress
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract It is shown that the parameters of antipyrine pharmacokinetics during cold exposure depend on individual resistance to hypoxia. High-resistant rats are characterized by less intense metabolism and more rapid normalization of pharmacokinetic parameters than lowresistant rats characterized by shortened elimination half-time corresponding to a more rapid metabolism of xenobiotics under conditions of cold stress.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02447243
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Biotransformation of hepatic xenobiotics in rats with various resistance to hypoxia exposure to after cold (1998)
    Springer
    Bulletin of experimental biology and medicine 126 (1998), S. 1203-1204 
    Details
    ISSN: 1573-8221
    Schlagwort(e): individual resistance to hypoxia ; hepatic monooxygenases ; cold ; adaptation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Hepatic monooxygenase activity was studied in rats with various resistance to hypoxia during adaptation to cold. Cold-induced change in the concentrations of cytochromes P-450 and b5 and the activity of microsomals metabolism of amidopyrine and aniline were shown to be associated with individual resistance to hypoxia. The content of microsomal cytochromes in highly resistant rats did not change on the fifth day of cold exposure. However, the intensity of metabolic reactions decreased. In low-resistance rats, a cold-induced decrease in the concentration of the cytochromes was not accompanied by significant changes in metabolic rates of amidopyrine and aniline.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02447150
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
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