ISSN:
1432-0428
Keywords:
IgE insulin antibody
;
insulin allergy
;
radioallergosorbent test
;
highly purified insulin
;
IgE
;
monocomponent insulin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary An in vitro method for detecting IgE insulin antibody using the principle of the radioallergosorbent test (RAST) is described. In six patients with insulin allergy, the RAST values were higher than in normal persons or insulin-treated diabetics without insulin-allergy. No differences were observed between normal persons and insulin-treated diabetics without insulin-allergy. Moreover, it was observed that in one patient treated with highlypurified insulin, there was a gradual decrease of RAST value parallel to the radioinsulin binding activity and clinical allergic symptoms. The RAST value of insulin is slightly inhibited by non-IgE antibodies and is, therefore, a semiquantitative value. However, the RAST is simple to perform and reproducible; It therefore is very useful in the detection of IgE insulin antibodies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429705
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