Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones (1971)
    Springer
    Diabetologia 7 (1971), S. 1-5 
    Details
    ISSN: 1432-0428
    Keywords: Intestinal hormones ; isolated pancreatic islets ; insulin release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'effet des hormones intestinales sécrétine, pancréozymine, gastrine-pentapeptide et glucagon sur la sécrétion d'insuline des ilôts pancréatiques isolés du rat a été étudié. Seule la pancréozymine et le glucagon se sont avérés stimuler la sécrétion d'insuline des ilôts isolés. La pancréozymine a produit cet effet sans glucose et le glucagon ne l'a produit qu'en présence de glucose dans le milieu. L'effet de la pancréozymine a été montré à plusieurs reprises en utilisant les même ilôts dans un système de perifusion dynamique. Ces études impliquent une classification des hormones intestinales, qui stimulent la sécrétion d'insuline selon que le tissu pancréatique exocrine intact est présent ou non.
    Abstract: Zusammenfassung Der Effekt der intestinalen Hormone Secretin, Pankreozymin, Gastrin-Pentapeptid und Glucagon auf die Insulinsekretion isolierter Langerhans'scher Inseln der Ratte wurde untersucht. Nur Pankreozymin und Glucagon stimulierten die Insulinsekretion der isolierten Inseln, Pankreocymin ohne, Glucagon nur bei Zusatz von Glucose zum Medium. Dieser Effekt von Pankreozymin war wiederholt an denselben Inseln in einem dynamischen Perifusionssystem nachzuweisen. Die Untersuchungen zeigen, daß die insulinstimulierende Wirkung der intestinalen Hormone zum Teil an ein funktionsfähiges exocrines Pankreasgewebe gebunden ist, zum Teil davon unabhängig zustande kommt.
    Notes: Summary The effect of the intestinal hormones secretin, pancreozymin, gastrin-pentapeptide and of glucagon upon insulin secretion of rat isolated pancreatic islets were studied. Only pancreozymin and glucagon were found to stimulate insulin release from the isolated islets, pancreozymin without and glucagon only in presence of glucose in the medium. The effect of pancreozymin was repeatedly shown by using the same islets in a dynamic perifusion system. The studies imply classification of the insulin stimulating actions of the intestinal hormones according to dependence upon and independence of the presence of intact exocrine pancreatic tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346246
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hypophysis and function of pancreatic islets (1973)
    Springer
    Diabetologia 9 (1973), S. 140-144 
    Details
    ISSN: 1432-0428
    Keywords: Hypophysectomy ; growth hormone ; corticotrophin ; insulin secretion ; biosynthesis of proinsulin and insulin ; protein synthesis ; isolated pancreatic islets ; epiphyseal cartilage of the tibia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypophysectomized rats were substituted with varying doses of human or porcine growth hormone (GH) as well as with ACTH for 6 or 12 days. Hypophysectomy was performed in animals of 80 or 170 g body weight either 12 or 4 weeks prior to the onset of the therapy. Increase in weight and the width of the epiphyseal cartilage were determined, insulin secretion and biosynthesis of proinsulin and insulin, were investigated in isolated pancreatic islets of the animals. — No differences were found between the effects of human and poreine GH preparations. Weight gain was similar in rats which had been hypophysectomized at a weight of 80 g either 12 or 4 weeks prior to the substitution. Secretion and biosynthesis of insulin which were both found to be reduced in isolated islets of untreated, hypophysectomized rats, were improved or normalized after substitution with GH (1 mg/kg/day) for 12 days. On the other hand, a therapy with GH for 6 days, even in tenfold daily dose (10 mg/kg), was ineffective in all rats which had been hypophysectomized at a weight of 80 g. Normalisation of lowered levels of blood sugar was the only positive effect observed after an administration of ACTH for 6 or 12 days. — It appears from our findings that, in contrast to the administration of ACTH, GH given to hypophysectomized rats for a longer period in relatively low doses may normalize both reduced secretion and biosynthesis of insulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01230694
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Hypophysis and function of pancreatic islets (1973)
    Springer
    Diabetologia 9 (1973), S. 135-139 
    Details
    ISSN: 1432-0428
    Keywords: Insulin secretion ; biosynthesis of proinsulin and insulin ; isolated pancreatic islets ; insulin content ; hypophysectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin secretion and biosynthesis of proinsulin and insulin were determined in isolated pancreatic islets of hypophysectomized rats. Control rats were of both same age and weight. Hypophysectomy was performed either 13 or 5 weeks prior to the investigation, the weight of the animals being either 80 or 170 g. Biosynthesis of insulin was estimated from the amounts of radioactivity incorporated into proinsulin and insulin after incubation of isolated islets at 50 or 300 mg% glucose in the presence of3H-leucine for 3 h. Islet proteins were separated on Sephadex G 50 fine. — Hypophysectomy resulted in a significant decrease of both glucose stimulated secretion and biosynthesis of insulin. It was found that this reduction was 1) more significant when compared with controls of same age 2) more marked in rats which had been hypophysectomized 13 weeks before than in rats after an interval of 5 weeks and 3) less in rats which had been hypophysectomized at a weight of 170 g than in rats in whom pituitary ablation was performed at a weight of 80 g. At basal glucose concentrations, no significant changes of both secretion and biosynthesis of insulin were apparent. The relation of radioactivity incorporated into proinsulin and insulin was unchanged under all conditions. Insulin content of the isolated islets used was found within about the same range in all rats, apart from the animals which had been hypophysectomized 13 weeks before. In islets of these rats, a reduction to 84% was observed. — Our findings may be explained by reduced sensitivity of the pancreatic B-cell to glucose and a slower rate of insulin biosynthesis after hypophysectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01230693
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...