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  • 1
    Electronic Resource
    Electronic Resource
    The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones (1971)
    Springer
    Diabetologia 7 (1971), S. 1-5 
    Details
    ISSN: 1432-0428
    Keywords: Intestinal hormones ; isolated pancreatic islets ; insulin release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'effet des hormones intestinales sécrétine, pancréozymine, gastrine-pentapeptide et glucagon sur la sécrétion d'insuline des ilôts pancréatiques isolés du rat a été étudié. Seule la pancréozymine et le glucagon se sont avérés stimuler la sécrétion d'insuline des ilôts isolés. La pancréozymine a produit cet effet sans glucose et le glucagon ne l'a produit qu'en présence de glucose dans le milieu. L'effet de la pancréozymine a été montré à plusieurs reprises en utilisant les même ilôts dans un système de perifusion dynamique. Ces études impliquent une classification des hormones intestinales, qui stimulent la sécrétion d'insuline selon que le tissu pancréatique exocrine intact est présent ou non.
    Abstract: Zusammenfassung Der Effekt der intestinalen Hormone Secretin, Pankreozymin, Gastrin-Pentapeptid und Glucagon auf die Insulinsekretion isolierter Langerhans'scher Inseln der Ratte wurde untersucht. Nur Pankreozymin und Glucagon stimulierten die Insulinsekretion der isolierten Inseln, Pankreocymin ohne, Glucagon nur bei Zusatz von Glucose zum Medium. Dieser Effekt von Pankreozymin war wiederholt an denselben Inseln in einem dynamischen Perifusionssystem nachzuweisen. Die Untersuchungen zeigen, daß die insulinstimulierende Wirkung der intestinalen Hormone zum Teil an ein funktionsfähiges exocrines Pankreasgewebe gebunden ist, zum Teil davon unabhängig zustande kommt.
    Notes: Summary The effect of the intestinal hormones secretin, pancreozymin, gastrin-pentapeptide and of glucagon upon insulin secretion of rat isolated pancreatic islets were studied. Only pancreozymin and glucagon were found to stimulate insulin release from the isolated islets, pancreozymin without and glucagon only in presence of glucose in the medium. The effect of pancreozymin was repeatedly shown by using the same islets in a dynamic perifusion system. The studies imply classification of the insulin stimulating actions of the intestinal hormones according to dependence upon and independence of the presence of intact exocrine pancreatic tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346246
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  • 2
    Electronic Resource
    Electronic Resource
    Hypophysis and function of pancreatic islets (1973)
    Springer
    Diabetologia 9 (1973), S. 140-144 
    Details
    ISSN: 1432-0428
    Keywords: Hypophysectomy ; growth hormone ; corticotrophin ; insulin secretion ; biosynthesis of proinsulin and insulin ; protein synthesis ; isolated pancreatic islets ; epiphyseal cartilage of the tibia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hypophysectomized rats were substituted with varying doses of human or porcine growth hormone (GH) as well as with ACTH for 6 or 12 days. Hypophysectomy was performed in animals of 80 or 170 g body weight either 12 or 4 weeks prior to the onset of the therapy. Increase in weight and the width of the epiphyseal cartilage were determined, insulin secretion and biosynthesis of proinsulin and insulin, were investigated in isolated pancreatic islets of the animals. — No differences were found between the effects of human and poreine GH preparations. Weight gain was similar in rats which had been hypophysectomized at a weight of 80 g either 12 or 4 weeks prior to the substitution. Secretion and biosynthesis of insulin which were both found to be reduced in isolated islets of untreated, hypophysectomized rats, were improved or normalized after substitution with GH (1 mg/kg/day) for 12 days. On the other hand, a therapy with GH for 6 days, even in tenfold daily dose (10 mg/kg), was ineffective in all rats which had been hypophysectomized at a weight of 80 g. Normalisation of lowered levels of blood sugar was the only positive effect observed after an administration of ACTH for 6 or 12 days. — It appears from our findings that, in contrast to the administration of ACTH, GH given to hypophysectomized rats for a longer period in relatively low doses may normalize both reduced secretion and biosynthesis of insulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01230694
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  • 3
    Electronic Resource
    Electronic Resource
    Hypophysis and function of pancreatic islets (1973)
    Springer
    Diabetologia 9 (1973), S. 135-139 
    Details
    ISSN: 1432-0428
    Keywords: Insulin secretion ; biosynthesis of proinsulin and insulin ; isolated pancreatic islets ; insulin content ; hypophysectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin secretion and biosynthesis of proinsulin and insulin were determined in isolated pancreatic islets of hypophysectomized rats. Control rats were of both same age and weight. Hypophysectomy was performed either 13 or 5 weeks prior to the investigation, the weight of the animals being either 80 or 170 g. Biosynthesis of insulin was estimated from the amounts of radioactivity incorporated into proinsulin and insulin after incubation of isolated islets at 50 or 300 mg% glucose in the presence of3H-leucine for 3 h. Islet proteins were separated on Sephadex G 50 fine. — Hypophysectomy resulted in a significant decrease of both glucose stimulated secretion and biosynthesis of insulin. It was found that this reduction was 1) more significant when compared with controls of same age 2) more marked in rats which had been hypophysectomized 13 weeks before than in rats after an interval of 5 weeks and 3) less in rats which had been hypophysectomized at a weight of 170 g than in rats in whom pituitary ablation was performed at a weight of 80 g. At basal glucose concentrations, no significant changes of both secretion and biosynthesis of insulin were apparent. The relation of radioactivity incorporated into proinsulin and insulin was unchanged under all conditions. Insulin content of the isolated islets used was found within about the same range in all rats, apart from the animals which had been hypophysectomized 13 weeks before. In islets of these rats, a reduction to 84% was observed. — Our findings may be explained by reduced sensitivity of the pancreatic B-cell to glucose and a slower rate of insulin biosynthesis after hypophysectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01230693
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  • 4
    Electronic Resource
    Electronic Resource
    Modeling anisotropic chemical wave patterns in the NO+H2 reaction on a Rh(110) surface (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 114 (2001), S. 9083-9098 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A realistic mathematical model describing the formation of anisotropic chemical wave patterns in the NO+H2 reaction on a Rh(110) surface is presented. For the point model describing the local reaction kinetics a bifurcation analysis has been conducted. In order to take into account the state-dependent anisotropy of surface diffusion site-blocking effects through coadsorbates for the diffusing species were introduced. The spatially distributed model reproduces well the experimentally determined excitability and bistability range and the existence ranges for the different types of chemical wave patterns: elliptical and rectangular target patterns, travelling wave fragments, and varying front geometries in the range of double metastability were modeled. In addition, the dependencies of the pulse/front velocity on the hydrogen partial pressure and temperature were simulated. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1362691
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  • 5
    Electronic Resource
    Electronic Resource
    Die bedeutung des nikotinsaureamids fur die synthese des nad in Ehrlich-Ascites-Tumorzellen
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 121 (1966), S. 228-240 
    Details
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(66)90112-7
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  • 6
    Electronic Resource
    Electronic Resource
    Significance of streptozotocin induced nicotinamide-adenine-dinucleotide (NAD) degradation in mouse pancreatic islets
    Amsterdam : Elsevier
    FEBS Letters 30 (1973), S. 225-228 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(73)80656-8
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of tolbutamide and glibenclamide on the incorporation of [^3H]leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets
    Amsterdam : Elsevier
    FEBS Letters 26 (1972), S. 237-240 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(72)80581-7
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  • 8
    Electronic Resource
    Electronic Resource
    Syntheses of polycyclic aromatic hydrocarbon-nucleoslde and oligonucleotide adducts specifically alkylated on the amino functions of deoxyguanosine and deoxyadenosine
    Amsterdam : Elsevier
    Tetrahedron Letters 31 (1990), S. 6773-6776 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)97168-5
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  • 9
    Electronic Resource
    Electronic Resource
    Prevention of hyperacute xenograft rejection in orthotopic xenotransplantation of pig hearts into baboons using immunoadsorption of antibodies and complement factors (2000)
    Springer
    Transplant international 13 (2000), S. S508 
    Details
    ISSN: 1432-2277
    Keywords: Key words Immunoadsorption ; Ig-Therasorb ; Hyperacute xenograft rejection ; Baboon ; Orthotopic xenotransplantation ; Xenoreactive antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To prevent hyperacute xenograft rejection (HXR) caused by preformed natural antibodies (XNAb) after orthotopic heart xenotransplantation (oXHTx) of landrace pig hearts into baboons, we used immunoadsorption of immunoglobulins IgG, IgM and IgA and complement with the reusable Ig-Therasorb column. In addition to functional data, tissue was sampled for histological, immunohistochemical and electron microscopical analysis. We performed three oXHTx of landrace pig hearts to baboons using extracorporeal circulation (ECC) connected to the immunoadsorption unit. Intraoperative treatment consisted of four cycles of immunoabsorption (IA). One oXHTx of a baboon without IA served as a control. A mismatch of donor and recipient heart size was prevented by selecting a 30–40 % lower body weight of donor pigs than recipients. Four cycles of IA removed more than 80 % of IgG, IgM and IgA, 86 % of anti-pig antibodies and 66 % of complement factors C3 and C4 from plasma. The graft of the control animal failed after 29 min. Orthotopic xenotransplantation with IA was selectively terminated after 100 min, 11 h and 21 h, respectively without any histological signs of HXR in light and electron microscopy. After weaning off from ECC these donor xenografts showed sufficient function with normal ECG and excellent cardiac output in echocardiography and invasive measurement (1.93 ± 0.035 l/min). The myocardium of the control xenograft demonstrated more deposits of Ig and complement components (C3, C4) than in the IA group. Baboons survive HXR after orthotopic pig heart xenotransplantation due to antibody depletion by reusable Ig-Therasorb column treatment. Long-term survival in an orthotopic baboon xenotransplantation model after IA, especially in combination with transgenic pig organs, could be a reliable preclinical trial for future clinical xenotransplantation programs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050392
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  • 10
    Electronic Resource
    Electronic Resource
    Influence of ischemic time on hyperacute xenograft rejection of pig hearts in a working heart perfusion model with human blood (2000)
    Springer
    Transplant international 13 (2000), S. S494 
    Details
    ISSN: 1432-2277
    Keywords: Key words Ischemic time ; Hyperacute xenograft rejection ; Xenotransplantation ; Ig-Therasorb column ; Immunoadsorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In xenotransplantation long ischemic time of grafts is supposed to have a marked influence on hyperacute rejection (HXR). We investigated the influence of different cold ischemic times on HXR of ex vivo “working pig hearts” perfused with human blood. Xenoreactive natural antibodies (XNAb) as a trigger of HXR were eliminated by Ig-Therasorb immunoadsorption (IA). Explanted Landrace pig hearts of group G1 and group G3 (with additional IA) underwent 4 h of cold ischemia prior to xenoperfusion. Control groups G2 and G4 (with IA) were kept ischemic for only 46.6 ± 15.8 and 51.2 ± 4.2 min, respectively. Ischemic time prolonged the perfusion time in our working heart model (G1: 356 ± 46.1 min; G2: 125 ± 31 min; P 〈 0.05). IA had no additional impact on perfusion time but was effective by itself. The heart weight increased fourfold more in G2 as compared to the other groups. IA without ischemia significantly improved cardiac output in G4 (G3: 198.8 ± 15.4 mL/min; G4: 338.5 ± 16.0 mL/min). Coronary flow in G2 was significantly lower than in G1 (G1: 157.9 ± 9.15 mL/min; G2: 59.4 ± 20.1 mL/min). Histological signs of HXR (light and electron microscopy) could be found in G2 in contrast to the other groups. Parameters of serological damage showed a minimum in G4 and the maximum in G2. In G1 XNAb were nearly equally eliminated immediately after the start of xenoperfusion as in IA groups G4 and G3. Four hours of ischemic time showed beneficial effects in preventing HXR, possibly caused by changes of the endothelial cell surface (for example, glycosylation or loss of α1–3Gal epitopes with a hapten effect).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050390
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