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  • Dipole source analysis  (1)
  • mantle-cell lymphoma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Identification of the visual motion area (area V5) in the human brain by dipole source analysis (1993)
    Springer
    Experimental brain research 93 (1993), S. 345-351 
    Details
    ISSN: 1432-1106
    Keywords: Visual motion perception ; Cortical motion ; area ; Dipole source analysis ; Evoked potentials ; Akinetopsia ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The retinal periphery of nine healthy subjects was stimulated with computer-generated random-dot kinematograms. These stimuli provided almost isolated visual motion information and minimal position cues. Pattern-reversal stimuli at the same location in the visual field were used for control. Stimulus-related electrical brain activity was recorded from 29 scalp electrodes. Total mean and individual data were analyzed with a spatiotemporal multiple dipole model. The scalp potentials showed a different spatial distribution for motion and pattern stimulation in the time range of 160–200 ms. In this epoch, the predominant motion-related source activity was localized in the region of the contralateral occipital-temporal-parietal border. A significant ipsilateral source activity was not found. The predominant source activity related to the pattern stimulus occurred in the same epoch. The corresponding equivalent dipole was localized more medially and deeper in the brain. The orientation of these major dipole activities was markedly different. These dipoles appeared to represent activity of distinct extrastriate areas, in contrast to earlier activity which was modelled by more posterior dipoles in the occipital lobe. The latter dipoles were at comparable contralateral locations and had similar peak activities around 100 ms, suggesting an origin in the striate cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228404
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  • 2
    Electronic Resource
    Electronic Resource
    Application of interphase cytogenetics for the detection of t(11;14)(q13;q32) in mantle cell lymphomas (1998)
    Springer
    Annals of oncology 9 (1998), S. 519-526 
    Details
    ISSN: 1569-8041
    Keywords: cytogenetics ; fluorescence in situ hybridization ; mantle-cell lymphoma ; translocation t(11;14)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The chromosomal translocation t(11;14)(q13;q32) is thehallmark of mantle cell lymphoma (MCL) in which it can be detectedcytogenetically in about 75% of cases. The t(11;14) translocationjuxtaposes the bcl-1 locus in chromosome band 11q13 next to the IgH locus inchromosome band 14q32 and, thus, leads to deregulation of the cell cycleregulatory protein cyclin D1, which is encoded by the CCND1 gene localizedat the telomeric border of the bcl-1-locus. MCL has the worst prognosis ofall low-grade non-Hodgkin‘s lymphomas (NHL). In some instances, however,histopathologic differentiation between MCL and other low-grade B-cell NHLis difficult. Therefore, detection of the t(11;14) translocation is ofessential diagnostic value for the risk-adjusted management of patients withMCL. Unfortunately, chromosome analyses are frequently hampered by the lowyield and quality of tumor metaphases. As the 11q13 breakpoints arescattered over a region of more than 120 kb the application of moleculargenetic techniques is also limited. Patients and methods: We established an interphase fluorescence in situhybridization (FISH) approach for the detection of the t(11;14)translocation by use of a cosmid probe hybridizing to the IgH constantregion and a YAC spanning the bcl-1 region. Cells containing a t(11;14)translocation show a co-localisation of the signals for IgH and bcl-1. Eightcontrol samples and 15 MCL specimens were investigated. Results: According to our control studies, samples containing more than10% of cells with this signal constellation can be diagnosed ascarrying a clonal t(11;14) translocation. All eleven MCL found to carry thet(11;14) translocation by chromosome analysis were positive in our FISHassay. Additionally, two of four MCL lacking a clonal t(11;14) translocationby chromosome analysis were shown to carry this aberration in 14% and37% of interphase nuclei. Southern blot data indicate that our FISHassay reliably detects the t(11;14) translocation irrespective of thelocation of the breakpoints within the bcl-1 region. Conclusions: The described interphase FISH assay provides a reliable androutinely applicable tool for diagnosis of the t(11;14) translocation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008242729509
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    Paper (German National Licenses)
    Fulltext
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