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  • 1
    Electronic Resource
    Electronic Resource
    Embryonale Fehlentwicklung bei Kaninchen nach hyperbarer Oxygenation (1972)
    Springer
    Anatomy and embryology 138 (1972), S. 289-300 
    Details
    ISSN: 1432-0568
    Keywords: Hyperbaric oxygen ; Rabbits ; Malformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gravide Kaninchen wurden am 9. Tag der Gestation für 5 Std einem Sauerstoffdruck von 1,5 oder 2,0 absoluten Atmosphären (ata) ausgesetzt. Am 29. Tag der Gravidität wurden die Muttertiere getötet, die Feten entnommen und die Uteri auf Resorptionsstellen untersucht. Von den Feten wurden nach der makroskopischen Inspektion Skeletpräparate hergestellt und diese lupenmikroskopisch auf Fehlbildungen untersucht. Die Befunde wurden mit unbehandelten Kontrollen verglichen. Die hyperbare Oxygenation führte zu einem Anstieg der Resorptionsrate und der Mißbildungsfrequenz. Die Fehlbildungen ließen sich bis auf zwei Ausnahmen dem Wirbel-Rippen-Syndrom zuordnen. Ein Fetus wies eine Spina bifida cystica auf, ein weiterer eine Omphalocele mit Leber- und partiellem Darmprolaps.
    Notes: Summary At the 9th day of pregnancy gravid rabbits were exposed to an oxygen pressure of 1.5 or 2.0 ata (absolute atmospheres) for 5 hours. The mother rabbits were killed on the 29th day of pregnancy. The foets were taken off and the uteri studied for resorptions. After macroscopic inspection sceleton preparations were made and inspected for malformations. The results were compared with untreated controls. Hyperbaric oxygen resulted in increased resorption rate and number of malformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00520709
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  • 2
    Electronic Resource
    Electronic Resource
    Embryonale Skeletmißbildungen nach Plasmaentzug bei graviden Kaninchen (1969)
    Springer
    Anatomy and embryology 129 (1969), S. 346-352 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Am 9. Tag der Gravidität wurde tragenden Bastardhäsinnen in Äther-Sauerstoff-Intubationsnarkose fraktioniert Blutplasma entzogen. 2. Der Flüssigkeitsverlust wurde durch 5% ige Laevuloselösung ersetzt. 3. Die Jungtiere der Versuchshäsinnen wurden nach der Geburt getötet und auf Skeletmißbildungen untersucht. 4. Bei 28 Jungtieren wurden Mißbildungen gefunden, die zum Symptomenkomplex des „Wirbel-Rippen-Syndroms” gehören. 5. Die Untersuchungen an 56 Kontrolltieren ergaben regelrechte Skeletbefunde. 6. die Untersuchungsergebnisse werden im Hinblick auf die Ursache der gefundenen Mißbildungen diskutiert.
    Notes: Summary 1. On the 9th day of pregnancy plasma was drawn fractionally from hybrid rabbits under ether — oxygen — anaesthesia by intubation. 2. Fluid volume loss was compensated by infusion of 5 p.c. laevulose solution. 3. The offspring were investigated for skeletal malformation by autopsy. 4. 28 of the progeny had skeletal malformations concerning to the thoracic spine, the ribs, and sternum. 5. Control investigatins in 56 offspring showed no skeletal malformation. 6. The experimental results are discussed under aspects of malformation causation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00521123
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  • 3
    Electronic Resource
    Electronic Resource
    Embryonale Fehlentwicklung bei Kaninchen nach künstlicher Hypothermie (1968)
    Springer
    Anatomy and embryology 126 (1968), S. 342-354 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es war das Ziel der Untersuchungen, den Einfluß der allgemeinen Hypothermie auf die Embryonalentwicklung von Kaninchen zu prüfen. Tragende Häsinnen wurden am. 9. oder 10. Tag der Gravidität in Äther — Sauerstoff — Narkose für 1–2 Std auf eine Körpertemperatur zwischen 25,0°C und 27,5°C abgekühlt. Bei 22 von insgesamt 37 nach Hypothermie geworfenen Jungtieren wurden Skeletmißbildungen gefunden. Form und Lokalisation der Mißbildungen zeigen, daß die Fehlentwicklungen in der sensiblen Entwicklungsphase zum Versuchszeitpunkt ausgelöst wurden. Kontrolluntersuchungen an 51 Jungtieren haben gezeigt, daß genetische Faktoren und die Äther-Sauerstoff-Narkose nicht die Ursache der gefundenen Mißbildungen sind. In Hypothermie sinkt die mittlere Sauerstoffspannung im Gewebe. Außerdem kommt es zu Änderungen des Elektrolytgehaltes im Serum und in den Organen. Beide Faktoren können bei der Entstehung der gefundenen Mißbildungen eine Rolle gespielt haben.
    Notes: Summary On the 9th or 10th day of pregnancy female rabbits were cooled down in ether — oxygen — anaesthesia for 1–2 hours to a body temperature between 25.0°C and 27.5°C. 37 new born rabbits were studied after hypothermic influence. 22 of these showed malformations of the skeleton. On the other hand there were found normal skeletons by 51 control animals. It is possible that the malformations are caused by the decrease of the oxygen tension in the tissue or by the alteration of the electrolytes in the serum and the organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00520799
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  • 4
    Electronic Resource
    Electronic Resource
    Intralymphatic interleukin-2 treatment of a hemophiliac AIDS patient with defective interleukin-2 production (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 380-386 
    Details
    ISSN: 1432-1440
    Keywords: Interleukin-2 ; Intralymphatic treatment ; AIDS ; Pneumocystis carinii pneumonia ; Immune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To improve immune functions in an interleukin-2 (IL-2) deficient hemophiliac AIDS patient suffering from severePneumocystis carinii pneumonia, treatment with IL-2 was started in addition to standard antimicrobioal therapy. Highly purified IL-2 was administered subcutaneously and then repeatedly intralymphatically in a manner similar to pedal lymphography. No toxicity was observed. The patient temporarily improved clinically as well as with regard to immunological functions. Particularly the in vitro response to phytohemagglutinin (PHA) could partly be restored, and skin tests revealed improved response to recall antigens. These findings indicate that IL-2 can be administered safely and effectively by the intralymphatic route and may — in addition to antibiotics — be of value in AIDS patients with severe opportunistic infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745579
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Verwendung des „Göttinger Miniaturschweines“ im teratologischen Experiment (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 1074-1074 
    Details
    ISSN: 1432-1440
    Keywords: Mini-pig ; malformation ; 6-amino-nicotinic acid amide ; critical phase of embryogenesis ; Miniaturschwein ; 6-Amino-nicotinsäureamid ; Mißbildungen ; sensible embryonale Entwicklungsphase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Erfassung sensibler embryonaler Entwicklungsphasen wurde graviden „Göttinger Miniaturschweinen“ 6-Amino-nicotinsäureamid intraperitoneal gespritzt. Am 10. und 16. Tag der Gestation führte die Behandlung mit 5 und 10 mg/kg Körpergewicht zu multiplen Fehlbildungen. Am 23. Tag der Gestation verursachte die Behandlung keine Fehlentwicklungen.
    Notes: Summary For the comprehension of sensible embryonal phases of development pregnant “Göttinger Miniaturschweine” were treated with intraperitoneal injection of 6-aminonicotinic acid amide with doses of 1, 5, 10 mg/kg body weight respectively. The sows were killed 1 week before the calculated birthtermin, the uteri were examined for resorption-marks and the fetuses explored for malformations. The treatment in the 10th day and 16th day of gestation with 5 and 10 mg/kg body weight caused multiple malformations. The malformation spectrum depended on the date of application. The treatment on the 23rd day of gestation caused no malformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468322
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  • 6
    Electronic Resource
    Electronic Resource
    Monozygote Zwillinge mit Klinefelter-Syndrom (konkordant) und systemischem Lupus erythematodes (diskordant) (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 906-910 
    Details
    ISSN: 1432-1440
    Keywords: Twins ; Diseases in twins ; Lupus erythematosus, systemic ; Klinefelter's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monozygotic twins, both with Klinefelter's syndrome, are presented. One of them had clinical and serological evidence of systemic lupus erythematosus (SLE), whereas the other did not show any immunological disorder. In relation to this case of discordant SLE the role played by exogenous factors in triggering the manifestation of this autoimmune disease under a certain genetic predisposition is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727439
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  • 7
    Electronic Resource
    Electronic Resource
    Fehlbildungen bei Kaninchen nach hyperbarer Oxygenation (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 248-250 
    Details
    ISSN: 1432-1440
    Keywords: Hyperbaric oxygen ; rabbits ; malformation ; Hyperbare Oxygenation ; Fehlbildungen ; Kaninchen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gravide Kaninchen wurden am 9. Tag der Gestation für 5 Std einem Sauerstoffdruck von 1,5 oder 2,0 absoluten Atmosphären ausgesetzt. Die Druckexposition führte zu einem Anstieg der Resorptionsrate und der Mißbildungsfrequenz.
    Notes: Summary At the 9th day of gestation pregnant rabbits were exposed to an oxygen pressure of 1.5 or 2.0 ata (absolute atmospheres) for 5 hours. The mother rabbits were killed on the 29th day of pregnancy. The foetuses were removed and the uteri studied for resorptions. After macroscopic inspection, skeleton preparations were made and inspected for malformations. The results were compared with untreated controls. Hyperbaric oxygen resulted in increased resorption rate and number of malformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01467776
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Experimentelle Untersuchungen zur Frage der teratogenen Wirkung von virusinduziertem Fieber (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 333-334 
    Details
    ISSN: 1432-1440
    Keywords: Rabbits ; Virus-induced fever ; Embryogenesis ; Kaninchen ; Virus-induziertes Fieber ; Embryonalentwicklung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am 9. Tag der Gestation wurde bei Kaninchen mit Hilfe eines hitzeinaktivierten Virus, das seine pyrogene Aktivität nicht verloren hatte, Fieber erzeugt. Am 29. Tag der Gravidität wurden die Muttertiere getötet, die Feten entnommen und die Uteri auf Resorptionen überprüft. Die Feten wurden makroskopisch auf Organ- und lupenmikroskopisch auf Skeletmißbildungen untersucht. Die Ergebnisse wurden mit Befunden von Kontrolltieren verglichen. Der Anstieg der Körpertemperatur führte zu keiner erhöhten Resorptions- und Mißbildungsrate.
    Notes: Summary Fever was induced in pregnant rabbits at the 9th day of gestation by injection of a heat inactivated virus which had not lost its pyrogenic activity. The mother rabbits were killed on the 29th day of pregnancy, the fetuses taken out and the uteri examined for resorptions. The fetuses were inspected for organ malformations macroscopically and for skeleton malformations microscopically. The results were compared with those of control animals. The rise of temperature up to maximum 2,1° C above normal temperature resulted in no higher resorption and malformation rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01471579
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  • 9
    Electronic Resource
    Electronic Resource
    Investigations of chromosomal stability in the Gorlin-Goltz syndrome (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 370-372 
    Details
    ISSN: 1432-069X
    Keywords: Gorlin-Goltz syndrome ; Chromosome instability ; Sister chromatid exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chromosomal studies were carried out on nine patients with the Gorlin-Goltz syndrome using recently developed methods on cultured lymphocytes. In addition, the dermatoglyphics of these patients were examined. No evidence of a characteristic chromosome aberration was found in banded prometaphase-chromosome preparations, nor could increased chromosome breakage be demonstrated in eight of the patients. One proposita showed frequent breaks of Chromosome 1 at p22. Increased chromosome instability in these patients was suggested by higher spontaneous and mitomycin-C-induced sister chromatid exchange rates in patients than in controls. Although the dermatoglyphic findings cannot be regarded as specific for the Gorlin-Goltz syndrome, an increased occurrence of whorl patterns and white lines in patients' fingerprints was noted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00509235
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  • 10
    Electronic Resource
    Electronic Resource
    Prenatal diagnosis of a short-rib-polydactylia syndrome type Saldino-Noonan at 17 weeks' gestation (1983)
    Springer
    European journal of pediatrics 140 (1983), S. 63-69 
    Details
    ISSN: 1432-1076
    Keywords: Short-rib-polydactylia syndrome ; Saldino-Noonan syndrome ; Prenatal diagnosis ; Ultrasound examinations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case is described in which the family history and the sonographic findings during the 17th gestational week led to the suspicion of a short-rib-polydactylia syndrome of the Saldino-Noonan type and an abortion was induced. The ultrasound image disclosed cystic structures in the topographic area of the kidney, marked ascites and oligohydramnios and indicated a severe fetal developmental disturbance. Due to the oligohydramnios the extremities could not be interpreted sonographically. The pathological-anatomical findings confirmed the suspected short-rib-polydactylia syndrome of the Saldino-Noonan type. Typical skeletal changes, dysgenetic cystic kidneys and pancreatic fibrosis were especially indicative of the syndrome. The complete agenesia of the islets of Langerhans, present in our observation, has, as far as we know, previously not been reported in the case of short-rib-polydactylia syndromes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00661909
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