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  • 1
    Electronic Resource
    Electronic Resource
    Structural analysis of bovine pancreatic thread protein (1990)
    Springer
    The protein journal 9 (1990), S. 623-632 
    Details
    ISSN: 1573-4943
    Keywords: Pancreatic thread protein ; primary structure ; mass spectrometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Pancreatic thread protein (PTP) forms double helical threads in the neutralpH range after purification, undergoing freely reversible,pH-dependent globule-fibril transformation. The purified bovine PTP consists on SDS gels of two carbohydrate-free polypeptide chains (Grosset al., 1985). Plasma desorption mass spectrometry and amino acid sequence analysis now confirm that bovine PTP contains two disulfide-bonded polypeptides, an A chain of 101 amino acid residues with a molecular weight of 11,073 and a B chain of 35 residues with a molecular weight of 3970. The intact protein exhibits a molecular weight of 15,036, agreeing 〉99.9% with the molecular weight calculated from the sequence. The B chain sequence was determined by gas-phase Edman degradation of the intact polypeptide. The A chain sequence was determined from overlapping peptides generated by cleavage at lysyl, tryptophanyl, and aspartyl-prolyl residues. Based upon the bovine PTP cDNA structure, the two chains of the protein result from cleavage of a single polypeptide with removal of a dipeptide between the NH2-terminal A chain and COOH-terminal B chain. Comparison of bovine PTP with other proteins reveals significant structural relatedness with the single-chain homologues from human and rat pancreas and with the motif associated with Ca2+-dependent carbohydrate recognition domains. The physiological role of PTP has not yet been resolved. The protein is present in very high concentration in pancreatic secretion and it has been detected in brain lesions in Alzheimer's disease and Down syndrome and in regenerating rat pancreatic islets. The present results provide a firm protein base for ongoing molecular, physical-chemical, and structure-function studies of this unusual protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01025016
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of a single glycosylated asparagine site on a glycopeptide using solid-phase Edman degradation (1994)
    Springer
    Glycoconjugate journal 11 (1994), S. 180-186 
    Details
    ISSN: 1573-4986
    Keywords: N-terminal sequencing ; glycoprotein ; glycan analysis ; covalent immobilization ; mass spectrometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The characterization of site-specific glycosylation is traditionally dependent on the availability of suitable proteolytic cleavage sites between each glycosylated residue, so that peptides containing individual glycosylation sites are recovered. In the case of heavily glycosylated domains such as theO-glycosylated mucins, which have no available protease sites, this approach is not possible. Here we introduce a new method to gain site-specific compositional data on the oligosaccharides attached to a single amino acid. Using a model glycopeptide from a mutant human albumin Casebrook, glycosylated PTH-Asn was recovered after sequential solid-phase Edman degradation, subjected to acid hydrolysis and the sugars were identified by high performance anion exchange chromatography with pulsed amperometric detection. The PTH-Asn(Sac) derivative was further characterized by ionspray mass spectrometry. Comparison between an endoproteinase Glu-C glycopeptide and a tryptic glycopeptide showed that the oligosaccharide attached to Asn494 was stable after at least 10 cycles of Edman degradation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00731216
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence for the Lack of a Human Metabolic Isotope Effect of a Deuterium Analog of Fluphenazine (1995)
    Springer
    Pharmaceutical research 12 (1995), S. 1388-1390 
    Details
    ISSN: 1573-904X
    Keywords: fluphenazine ; stable isotope ; deuterium labeled ; mass spectrometry ; schizophrenics ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016298329188
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  • 4
    Electronic Resource
    Electronic Resource
    Further Alkaloids Common to Ants and Frogs: Decahydroquinolines and a Quinolizidine (1999)
    Springer
    Journal of chemical ecology 25 (1999), S. 1179-1193 
    Details
    ISSN: 1573-1561
    Keywords: Alkaloids ; mass spectrometry ; infrared spectroscopy ; amphibians ; ants ; decahydroquinolines ; quinolizidines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Three alkaloids—two minor decahydroquinolines (DHQs) and a major quinolizidine—were detected in an extract of a Brazilian myrmicine ant (Solenopsis (Diplorhoptrum) sp. picea group). One DHQ (3) was identical to a known frog-skin alkaloid, cis-195A (cis-5-methyl-2-propyldecahydroquinoline), while the second DHQ, an isomer of 3, designated 195J, was assigned a tentative cis-2-methyl-5-propyldecahydroquinoline structure (2) based on mass and infrared spectra. The third alkaloid proved identical to the frog-skin alkaloid 195C, for which a structure had not been previously proposed. Mass and infrared spectral analysis, including chemical ionization tandem mass spectrometry, indicated a 4-methyl-6-propylquinolizidine structure (1) for 195C. The four possible diastereomers were synthesized and the (6Z,10E)-4-methyl-6-propylquinolizidine diastereomer (1b) was identical to the natural alkaloid. Skin extracts of a population of a Madagascan mantelline frog contained, among other alkaloids, minor amounts of the same alkaloid triad 1–3 with 1 again predominating. The common occurrence of alkaloids 1–3 in both ant and frog supports the hypothesis that ants are a likely dietary source for sequestered frog-skin alkaloids and brings to six, the alkaloid classes common to ant and frog.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1020898229304
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  • 5
    Electronic Resource
    Electronic Resource
    Pteridine, XXXIII. Synthese und Struktur 8-substituierter Lumazine (1966)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 99 (1966), S. 3503-3523 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Verschiedene N-8-substituierte Lumazine werden synthetisch erhalten und durch ihre pK-Werte und UV-Absorptionsspektren charakterisiert. Die Neutralmoleküle und Monokationen zeigen übereinstimmende Strukturen, wogegen im alkalischen pH-Bereich unter normalen Bedingungen wenig übereinstimmende physikalische Daten erhalten werden. Kovalente Hydratation an das konjugierte System in 1.7-Stellung führt zu Gleichgewichtsgemischen verschiedener Molekülformen. Zur Klärung der Verhältnisse werden mit Hilfe einer Schnell-bestimmungsmethode die wahren pK-Werte und UV-Spektren der zum Teil instabilen Molekülformen bestimmt. Durch kinetische Messungen am 6.7.8-Trimethyl-lumazin (16) wird gezeigt, daß sich bei 6.7-Dimethyl-8-alkyl-lumazinen an die Wasseraddition noch eine reversible Ringöffnung des Pyrazinringes anschließt.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19660991117
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  • 6
    Electronic Resource
    Electronic Resource
    Synthesis and structure of Cp3U=CHPMe3: A compound with a U=C multiple bond (1988)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 121 (1988), S. 417-420 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Synthese und Struktur von Cp3U=CHPMe3: Eine Verbindung mit U=C-MehrfachbindungGrünes, kristallines Cp3U=CHPMe3 wurde durch Umsetzung von Cp3UCl mit Li[CH2]2PMe2 oder H2C=PMe3 dargestellt. Seine Kristallstruktur wurde durch Röntgenbeugungsanalyse an Einkristallen bestimmt. Der kurze U=CH-Abstand von 2.274(8) Å und der große Winkel U—C—P von 143.5(5)° deuten Uran-Kohlenstoff-Mehrfachbindungscharakter an. Die 1J (13C1H)-Kopplungskonstanten in den CH-Gruppen zwischen Uran und Phosphor von Cp3U=CHPMe3 (95 Hz), Cp3U=CHPMe2Ph (100 Hz) und Cp3U=CHPPh2Me (113 Hz) sind auffallend klein. Den Strukturdaten kann aber keine agostische UCHP-Wechselwirkung entnommen werden.
    Notes: Green, crystalline Cp3U=CHPMe3 has been synthesized by the reaction of Cp3UCl with Li[CH2]2PMe2 or CH2=PMe3. Its crystal structure has been determined by single crystal X-ray diffraction. The short U=CH bond distance, 2.274(8) Å, and large U—C—P angle, 143.5(5)°, indicate uranium-carbon multiple bond character. The 1J(13C1H) coupling constants within the CH group between uranium and phosphorus in Cp3U=CHPPh2Me (95 Hz), Cp3U=CHPMe2Ph (100 Hz), and Cp3U=CHPPh2Me (113 Hz) are surprisingly small, but no agostic interaction UCHP can be derived from the structural data.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19881210306
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  • 7
    Electronic Resource
    Electronic Resource
    Supermolecules Containing a Tetrahedral Core: A New Class of Liquid-Crystalline Siloxanes (1996)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 129 (1996), S. 521-525 
    Details
    ISSN: 0009-2940
    Keywords: Liquid crystals ; Siloxanes ; Phase behaviors ; Defined topology ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: It is shown that supermolecules with a tetrahedral symmetry and appropriate side-chains exhibit liquid-crystalline phase behaviour. The use of an optimised hydrosylation reaction allows for the synthesis of materials that have four mesogenic groups attached to a siloxane core, where the conformation and the configuration are unambiguous. The materials show low glass transition temperatures and, depending on the spacer length, complex liquid-crystalline morphologies.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19961290508
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  • 8
    Electronic Resource
    Electronic Resource
    Lösliche Lanthanid-alkoxide mit niedrigen Koordinationszahlen am Metall-Atom (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 1163-1165 
    Details
    ISSN: 0009-2940
    Keywords: Lanthanide alkoxides ; Tritox ligand ; Neodymium ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Soluble Lanthanide Alkoxides with Low Coordination Numbers at the Metal AtomNd[N(SiMe3)2]3(thf)2 (1) reacts with tBu3COH (2) to give the monomeric lanthanide alkoxide (tritox)3Nd(thf) (3). The chloro-bridged dimer [(tritox)2Nd(μ-Cl)thf]2 (6) is obtained by treatment of NdCl3(thf)2 (4) with LiOCtBu3 (5). The structure of 6 has been determined by X-ray crystallography.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240530
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  • 9
    Electronic Resource
    Electronic Resource
    Synthese und Strukturen von metallhaltigen achtgliedrigen N  -  S  -  O-Heterocyclen (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 1917-1921 
    Details
    ISSN: 0009-2940
    Keywords: Aluminium heterocycles ; Gallium heterocycles ; Indium heterocycles ; NSO complexes ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis and Structures of Metal-Containing Eight-Membered N  -  S  -  O HeterocyclesRacemic N-alkylsulfinamides 1a, b react with aluminium, gallium, and indium alkyls 2a  -  d to form puckered eight-membered NSO-complexes [Me2AlN(CF3)2C6H3S(tBu)O]2 (3a), [Me2AlN-(Ph)S(tBu)O]2 (3b), [Me2GaN(CF3)2C6H3S(tBu)O]2 (3c), [(Me3- SiCH2)2GaN(CF3)2C6H3S(tBu)O]2 (3d), [(Me3SiCH2)2InN(Ph)S- (tBu)O]2 (3e), and [(Me3SiCH2)2InN(CF3)2C6H3S(tBu)O]2 (3f). Compounds 3a, c, d crystallize in the triclinic space group P¯1. A comparision of the X-ray structures of 3a, c, d reveals that the sulfur atoms in one molecule of 3d have either (R,R) or (S,S) configuration (Z = 2). In the case of less bulky ligands at the metal atoms (3a, c) both configurations at the sulfur atoms (R,S) are present in one molecule (Z = 1).
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240906
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  • 10
    Electronic Resource
    Electronic Resource
    Bor-Stickstoff-Verbindungen, IV: Reaktionen der B-Amino-borazole (1961)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 94 (1961), S. 671-676 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Bortrichlorid, Phosphoroxychlorid, Alkohole und N.N-Dimethyl-hydrazin reagieren mit B-Amino-borazolen unter Sprengung der B-Amino-Bindung, während der Borazolring erhalten bleibt. B-Hydrazino-borazole und ein B-Aminoborazol mit freier NH2-Gruppe konnten erstmalig dargestellt werden. Versuche zur Isolierung eines N-Trihydroxy-borazols werden mitgeteilt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19610940315
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