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  • method of multipliers  (2)
  • Key words Paraquat  (1)
  • Pro-sequence, Site-directed mutagenesis  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Achievement of renaturation of subtilisin BPN' by a novel procedure using organic salts and a digestible mutant of Streptomyces subtilisin inhibitor
    Amsterdam : Elsevier
    FEBS Letters 342 (1994), S. 193-196 
    Details
    ISSN: 0014-5793
    Schlagwort(e): Pro-sequence, Site-directed mutagenesis ; Protein folding ; Serine protease ; Streptomyces subtilisin inhibitor ; Subtilisin BPN'
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)80499-0
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  • 2
    Digitale Medien
    Digitale Medien
    Paraquat causes S-phase arrest of rat liver and lung cells in vivo (1996)
    Springer
    Archives of toxicology 70 (1996), S. 514-518 
    Details
    ISSN: 1432-0738
    Schlagwort(e): Key words Paraquat ; Tungsten ; Xanthine oxidase ; Intoxication ; Flow cytometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  We examined the in vivo effect of paraquat on the cell cycle in rat liver and lung tissues and the protective effect of tungsten (a xanthine oxidase inhibitor) on paraquat toxicity. The bromodeoxy- uridine/propidium iodide double-staining method and flow cytometry were used for cell cycle assessment. Wistar rats were fed a standard diet or a tungsten-enriched diet were injected intravenously with 20 mg/kg paraquat, while uninjected rats served as controls. At 1, 3, and 5 days after paraquat injection, the liver and lungs were removed for examination following in vivo labeling with 20 mg/kg bromo- deoxyuridine for 1 h. Liver and lung cells were isolated and incubated with an anti-bromodeoxyuridine antibody and with propidium iodide for DNA staining. Flow cytometry showed that the S-phase cell populations in the liver and lungs of paraquat-injected rats fed a standard diet were increased markedly on days 1 and 3 after injection compared with the control levels. However, on day 5 the liver cells had nearly returned to normal, while the S-phase population remained high in the lungs. In contrast, the S-phase cell populations of liver and lung tissue showed no increase after paraquat injection in rats fed a tungsten-enriched diet. These findings suggest that paraquat-induced cytotoxicity is more prolonged in the lungs than in the liver. In addition, paraquat toxicity appears to be mediated by xanthine oxidase and xanthine oxidase inhibitors may be useful as an antidote.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002040050308
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  • 3
    Digitale Medien
    Digitale Medien
    An infeasible method of large-system optimization by direct coordination of subsystem inputs (1978)
    Springer
    Journal of optimization theory and applications 24 (1978), S. 437-448 
    Details
    ISSN: 1573-2878
    Schlagwort(e): Decomposition techniques ; generalized Lagrangian ; large-systems optimization ; method of multipliers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract An infeasible method of large-system optimization is proposed. The dual gap is resolved by use of the generalized Lagrangian as in the previous methods due to Stephanopouloset al. and Watanabeet al. The values of subsystem inputs are, however, coordinated in the second level, instead of being adjusted in the first level, as in previous methods. As a result, in contrast with previous methods, the subproblems in the first level include a small number of variables to be adjusted; in addition, the generalized Lagrangian is decomposable in a simple manner. Further, the decomposition is not subject to any restriction, which is often encountered in feasible methods.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00932887
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  • 4
    Digitale Medien
    Digitale Medien
    Decomposition in large system optimization using the method of multipliers (1978)
    Springer
    Journal of optimization theory and applications 25 (1978), S. 181-193 
    Details
    ISSN: 1573-2878
    Schlagwort(e): Decomposition techniques ; generalized Lagrangian ; large system optimization ; method of multipliers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Although the method of multipliers can resolve the dual gaps which will often appear between the true optimum point and the saddle point of the Lagrangian in large system optimization using the Lagrangian approach, it is impossible to decompose the generalized Lagrangian in a straightforward manner because of its quadratic character. A technique using the linear approximation of the perturbed generalized Lagrangian has recently been proposed by Stephanopoulos and Westerberg for the decomposition. In this paper, another attractive decomposition technique which transforms the nonseparable crossproduct terms into the minimum of sum of separable terms is proposed. The computational efforts required for large system optimization can be much reduced by adopting the latter technique in place of the former, as illustrated by application of these two techniques to an optimization problem of a chemical reactor system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00933211
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