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  • 1
    Digitale Medien
    Digitale Medien
    Shielding current density in Mg-doped YBCO-123 as determined by a.c. magnetic-susceptibility measurements (1994)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 1941-1946 
    Details
    ISSN: 0392-6737
    Schlagwort(e): Superconducting materials ; General properties ; Critical currents ; Material effects onT c,x, critical currents (including impurities, ion implantation etc.) ; Conference proceedings
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Summary High-resolution a.c. magnetic-susceptibility measurements have been performed on sintered samples of Mg-doped YBCO superconductors YBa2(Cu1−x Mg x )3O7−δ (δ≤0.08, 0≤x≤0.1). An estimation of the intergranular shielding currentsJ s (T, H d.c.) has been obtained by separating the grains and coupling-junctions contributions to the measured susceptibility. The results show that Mg doping increases the weak links weight and reduces the values ofJ s. AtH d.c.=0,J s (T, 0) follows a power law of the type (1−T/T c)β, with β varying from 2 (undoped sample) to about 5 (x=2.5%). The dependence ofJ s on the applied d.c. magnetic field can be fitted to a Lorentzian lineshape whose width appears to be independent of the substitution level.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02462197
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Correlations between microstructure and a.c. magnetic response of bulk superconducting YBa2Cu3O7−x (1995)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 17 (1995), S. 381-391 
    Details
    ISSN: 0392-6737
    Schlagwort(e): Superconducting materials ; General properties ; Critical currents
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Summary The magnetic response of granular superconducting YBCO samples with different grain sizes is reported. The analysis is carried out by measuring the low-frequency a.c. magnetic susceptibility as a function of the temperature with an applied magnetic field of amplitude ranging between 0.4 and 800 A/m. The observed magnetic behaviour is interpreted in terms of grain size and weak-links properties. The experimental results evidence the influence of the sample microstructure on the magnetic susceptibility. The intergranular and intragranular onset temperatures are compared with the critical temperature of the samples obtained by means of electrical-resistivity measurements. The temperature dependence of the intergranular critical current density is derived from the susceptibility data.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02457340
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  • 3
    Digitale Medien
    Digitale Medien
    Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors (1998)
    Springer
    Annals of oncology 9 (1998), S. 733-738 
    Details
    ISSN: 1569-8041
    Schlagwort(e): gemcitabine ; paclitaxel ; phase I
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: Paclitaxel and gemcitabine possess broad spectra of clinical activity, distinct mechanisms of cytotoxicity, and are differentially affected by mutations in cell-cycle regulatory proteins, such as bcl-2. This phase I trial was designed to identify the maximum tolerated dose (MTD) and dose limiting toxicities (DLT) of paclitaxel and gemcitabine when both drugs were given together on a once-every-two-week schedule in patients with solid tumors. Patients and methods: A total of 37 patients were treated at nine different dose levels ranging from paclitaxel 75–175 mg/m2 administered over three hours followed by gemcitabine 1500–3500 mg/m2 administered over 30–60 minutes. Both drugs were administered on day 1 of a 14-day cycle. Dose escalation was performed in a stepwise manner in which the dose of one drug was escalated while the dose of the other drug was kept constant. Results: Dose limiting toxicity (DLT) was observed at dose level 9: paclitaxel 175 mg/m2 and gemcitabine 3500 mg/m2 in the form of grade 4 neutropenia lasting for ≥5 days (one patient) and grade 3 elevation of alanine aminotransferase (AST/SGPT) (one patient). An analysis of delivered dose intensity (DI) over the first three cycles revealed that higher dosages of both drugs were delivered at dose level 7, paclitaxel 150 mg/m2 and gemcitabine 3000 mg/m2 dose level, than at the MTD, dose level 8, paclitaxel 150 mg/m2 and gemcitabine 3500 mg/m2. Partial responses were confirmed in two patients with transitional cell carcinoma (one of the bladder, one of the renal pelvis) and in one patient with adenocarcinoma of unknown primary. Conclusions: Paclitaxel and gemcitabine is a promising drug combination that can be administered safely and repetitively on an every-other-week schedule. Using this drug administration schedule, the recommended phase II dose is paclitaxel 150 mg/m2 and gemcitabine 3000 mg/m2.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008286908930
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