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  • 1990-1994  (4)
  • pharmacokinetics  (2)
  • thermal conductivity  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of SUN 1165, a new antiarrhythmic agent, in renal dysfunction (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 411-414 
    Details
    ISSN: 1432-1041
    Schlagwort(e): SUN 1165 ; renal failure ; antiarrhythmic agent ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of a new Class I antiarrhythmic agent, SUN 1165, has been studied in 32 patients with varying degrees of renal impairment following a single oral dose of 50 mg. The apparent volume of distribution at steady state was 1.48 1 · kg−1, the absorption rate constant was 2.2 h−1, and plasma protein binding was 26.8% in subjects with normal renal function. These variables were not altered with renal impairment. More than 60% of SUN 1165 given orally was excreted unchanged via the kidney, both by tubular secretion and glomerular filtration. The elimination rate constant, the apparent total body clearance and the apparent renal clearance were linearly correlated with the endogenous creatinine clearance. The half-time of elimination was 3.4 h in normal subjects and it was prolonged to 23.7 h in severe renal failure (creatinine clearance below 20 ml · min−1 · 1.48 m−2). Dosage adjustment of SUN 1165 is necessary in renal failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00265853
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  • 2
    Digitale Medien
    Digitale Medien
    Measurement of the thermal conductivity of molten InSb under microgravity (1991)
    Springer
    International journal of thermophysics 12 (1991), S. 783-790 
    Details
    ISSN: 1572-9567
    Schlagwort(e): InSb ; microgravity ; molten InSb ; thermal conductivity ; transient hot-wire method ; space experiment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Thermal conductivity of molten InSb was measured on board the TEXUS-24 sounding rocket by the transient hot-wire method using the originally designed thermal conductivity measurement facility (TCMF). Measurements made through this facility were affected by natural convection on the ground. This natural convection was confirmed to be sufficiently suppressed during a microgravity environment. The thermal conductivity of molten InSb was 15.8 and 18.2 W·m−1·K−1 at 830 and 890 K, respectively.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00502405
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  • 3
    Digitale Medien
    Digitale Medien
    Thermophysical properties data on molten semiconductors (1992)
    Springer
    International journal of thermophysics 13 (1992), S. 1061-1084 
    Details
    ISSN: 1572-9567
    Schlagwort(e): density ; GaAs ; GaSb ; Ge ; high temperature ; InP ; InSb ; molten state ; semiconductors ; Si ; surface tension ; thermal conductivity ; viscosity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Thermophysical properties of molten semiconductors are reviewed. Published data for viscosity, thermal conductivity, surface tension, and other properties are presented. Several measurement methods often used for molten semiconductors are described. Recommended values of thermophysical properties are tabulated for Si, Ge, GaAs, InP, InSb, GaSb, and other compounds. This review shows that further measurements of thermophysical properties of GaAs and InP in the molten state are required. It is also indicated that a very limited amount of data on emissivity is available. Space experiments relating to thermophysical property measurements are described briefly.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01141216
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  • 4
    Digitale Medien
    Digitale Medien
    The pharmacokinetics of primaquine in calves after subcutaneous and intravenous administration (1993)
    Springer
    Veterinary research communications 17 (1993), S. 129-136 
    Details
    ISSN: 1573-7446
    Schlagwort(e): calves ; carboxyprimaquine ; pharmacokinetics ; plasma ; primaquine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The pharmacokinetics of primaquine was studied in calves of 180–300 kg live weight. Primaquine was injected at 0.29 mg/kg (0.51 mg/kg as primaquine diphosphate) intravenously (IV) or subcutaneously (SC) and the plasma concentrations of primaquine and its metabolite carboxyprimaquine were determined by high-performance liquid chromatography. The extrapolated concentration of primaquine at zero time after IV administration was 0.50±0.48 µg/ml (mean ±SD) which decreased with an elimination half-life of 0.16±0.07 h. Primaquine was rapidly converted to carboxyprimaquine after either route of administration. The peak concentration of carboxyprimaquine was 0.50±0.08 µg/ml at 1.67±0.15 h after IV administration. The corresponding value was 0.47±0.07 µg/ml at 5.05±1.20 h after SC administration. The elimination half-lives of carboxyprimaquine after IV and SC administration were 15.06±0.99 and 12.26±3.06 h, respectively. The areas under the concentration-time curve for carboxyprimaquine were similar following either IV or SC administration of primaquine; the values were 11.85±2.62 µg.h/ml after the former and 10.95±2.65 µg.h/ml after the latter. The mean area under the concentration-time curve for primaquine was less than 0.1 µg.h/ml after either route of administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01839241
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