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Digitale Medien

Pharmacokinetics of cefoxitin administered by i.v. infusion to patients with a pleural effusion (1984)

Otero, M. J. ; Garcia, M. J. ; Barrueco, M. ; [weitere]

Springer

European journal of clinical pharmacology 26 (1984), S. 389-392

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Details

ISSN: 1432-1041

Schlagwort(e): cefoxitin ; beta-lactam antibiotics ; pharmacokinetics ; serum concentration ; pleural fluid concentration

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pleural fluid in all cases was 2–3fold longer than from serum, which shows a difference between the kinetic elimination processes of the antibiotic from the two fluids. The slow elimination of cefoxitin from pleural fluid facilitates its accumulation in this compartment during a multiple dosage regimen.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00548772

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