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  • 1
    Electronic Resource
    Electronic Resource
    Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats (1990)
    Springer
    Journal of neural transmission 80 (1990), S. 189-194 
    Details
    ISSN: 1435-1463
    Keywords: Nicotine enantiomers ; pain ; spinal analgesia ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spinalized rats received an intrathecal injection of either (−)-nicotine or (+)-nicotine in order to study the stereoselectivity of antinociception. Pain threshold was measured using the tail-flick test. Both stereoisomers had antinociceptive effects, but (−)-nicotine was up to 970 times more potent, depending on test conditions. The antinociceptive action of (−)-nicotine was antagonized by mecamylamine and yohimbine but not by naloxone and atropine. The findings show that spinal mechanisms are highly stereoselective toward nicotine, and suggest that primarily nicotinergic andalpha-adrenergic receptors are involved in its central antinociceptive effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245120
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of tranylcypromine enantiomers on monoamine uptake and release and imipramine binding (1986)
    Springer
    Journal of neural transmission 65 (1986), S. 135-145 
    Details
    ISSN: 1435-1463
    Keywords: Tranylcypromine enantiomers ; monoamine uptake ; monoamine release ; dopamine ; noradrenaline ; serotonin ; synaptosome ; imipramine binding ; blood platelet ; stereoselectivity ; rat ; rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies were carried outin vitro to determine effects of tranylcypromine enantiomers ([+]- and [−]-TCP) on uptake and release of 5-HT, DA and NA in rat synaptosomes and on imipramine binding to rabbit platelets. (+)-TCP was more potent than (−)-TCP as inhibitor of 5-HT uptake and imipramine binding, whereas (−)-TCP was more potent than (+)-TCP as inhibitor of DA and NA uptake. The enantiomers differed only slightly in their effects on monoamine release. The findings agree with previous reports on the stereoselectivity of monoaminergic mechanisms toward TCP enantiomers, and support the notion that the 5-HT uptake site may be associated with the imipramine binding site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01256489
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine diastereomers on monoamine uptake and monoamine oxidase in rat brain (1992)
    Springer
    Journal of neural transmission 88 (1992), S. 177-185 
    Details
    ISSN: 1435-1463
    Keywords: Phenylpiperazine ; monoamine uptake ; NA ; DA ; 5-HT ; MAO ; phenylethylamine ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The diastereomers of 3,N,N′-trimethyl-2-phenyl-1,4-piperazine dihydrochloride (TPP) were tested for their effects on NA, DA and 5-HT uptake in synaptosomes prepared from hypothalamus, corpus striatum, and frontal cortex, respectively. The diastereomers differed with respect to their inhibitory properties. (2R, 3R)-TPP was more potent than the other diastereomers on NA and DA uptake, whereas (2S, 3S)-TPP was least potent. In contrast, the (2S, 3S)- and (2 S, 3R)-diastereomers of TPP were more potent than (2R, 3R)- and (2R, 3S)-TPP as inhibitors of 5-HT uptake. None of the diastereomers affected monoamine oxidase activity. The findings show that the diastereomers of TPP interact stereoselectively with neuronal mechanisms for monoamine uptake, and that the (S)-configuration at the 2 carbon is important for inhibitory actions of TPP on 5-HT uptake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244731
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  • 4
    Electronic Resource
    Electronic Resource
    Kβ/Kα intensity ratios for elements of atomic number 20 to 30 (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 3 (1974), S. 149-150 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Twenty-five new measurements of Kβ/Kα X-ray intensity ratios for elements in the atomic number range 20 to 30 confirm other recent evidence that the variation with atomic number in this region is much less than previously thought, but there is still some disagreement for atomic numbers above 27. A table of recommended values is given.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300030405
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  • 5
    Electronic Resource
    Electronic Resource
    The calculation of background in wavelength-dispersive electron microprobe analysis (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 10 (1981), S. 198-202 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A procedure has been developed for the calculation of background corrections in wavelength-dispersive electron microprobe analysis which reduces data acquisition times and offers the possibility of greater accuracy and lower detection limits, especially when the number of peaks concerned is large. An empirical ‘normalized background’ in conjunction with a modified version of Kramers' law (as developed for energy-dispersive analysis) is used to calculate continuum intensity, enabling the background to be estimated for any wavelength from a single measured value. This approach is compatible with modern trends towards automation of data acquisition and processing.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300100412
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  • 6
    Electronic Resource
    Electronic Resource
    High resolution mass spectrometry in molecular structure studies - V: The fragmentation of amaryllis alkaloids in the crinine seriesFor Part IV, see Ref. 1. (1973)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 7 (1973), S. 401-415 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: High resolution mass spectral fragmentation patterns of Amaryllidaceae alkaloids in the crinine series have been investigated as well as those of certain isotopically labeled derivatives. Attention is directed to the particular importance of employing entire high resolution mass spectra in attempting the elucidation of structural correlations in compounds which display few significant relative intensity variations in a complex fragmentation pattern.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210070405
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  • 7
    Electronic Resource
    Electronic Resource
    Mass spectrometry in structural and stereochemical problems - CCXXII:For Part CCXXI, see K. Tomer and C. Djerassi, Org. Mass Spectrom. 6, 1285 (1972). Delineation of competing fragmentation pathways of complex molecules from a study of metastable ion transitions of deuterated derivatives (1973)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 7 (1973), S. 367-381 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Data on defocused metastable ions have been obtained for a series of structurally significant fragment ions in the mass spectra of the estrogenic steroid, estrone methyl ether and the alkaloid tropine. These data, in conjunction with measurements on defocused metastable ions in the mass spectra of isotopically labeled analogs and complete high resolution mass spectra provide important insights into the details of fragmentation processes, specifically: (a) an enumeration and determination of the frequent multiple origins of fragment ions in the mass spectra of such complex molecules, (b) specification of skeletal atoms lost and retained in concerted (one step) processes, and at each step of stepwise processes, leading to a particular fragment ion and (c) information on the relative contributions of concerted and stepwise processes resulting in the genesis of a given ion.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210070402
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement of oxygen K absorption spectra using an electron microprobe (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 4 (1975), S. 65-70 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: A technique is outlined which use the electron microprobe to obtain X-ray absorption spectra, by photon absorption, in the long wavelength region. Spectra are presented for SiO, SiO2, rectorite, talc, vermiculite, V2O5, Cr2O3, Fe2O3, maghemite, Mylar and collodion. For all compounds the main absorption edge is near to 536 eV, which is significantly higher than core binding measured in ESCA studies. The transition metal oxides and organic films show a sharp absorption line near 531 eV in addition to the above edge. This absorption line is very close in energy to the anomalous peak observed in the oxygen K emission spectra when using KAP or other acid phthalate crystals and it seems likely that the two phenomena are associated.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300040206
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  • 9
    Electronic Resource
    Electronic Resource
    The atomic number dependence of the X-ray continuum intensity and the practical calculation of background in energy dispersive electron microprobe analysis (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 4 (1975), S. 149-156 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Computer fitting techniques have been used to derive a new expression for the relationship between X-ray continuum intensity and atomic number for a range of electron acelerating potentials up to 25 kV, continuum energies up to 10 keV and average atomic numbers up to thirty. A practical approach to background corrections in energy dispersive electron microprobe analysis, which utilizes this expression, is outlined. The procedure should lead to significant improvements in both accuracy and detection limits in this method of X-ray analysis.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300040311
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  • 10
    Electronic Resource
    Electronic Resource
    Window contamination of energy-dispersive detectors in electron microprobe analysis (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 10 (1981), S. 78-81 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Oil film contamination of the Be window of a Si detector has been demonstrated using archival information on X-ray intensities from calibration standards acquired over a two and a half year period. Although cleaning the window with a solvent restores sensitivity for soft radiation, recontamination can be rapid unless a small heating device is placed close to the window. A mathematical correction is suggested which avoids significant analytical errors from the effect of any contamination which may be present. It can be applied automatically by data processing software using information from the calibration standard spectrum.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300100209
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