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  • 1
    Digitale Medien
    Digitale Medien
    Clinical evaluation of gastric fundic gland polyps without familial polyposis coli (1995)
    Springer
    Abdominal imaging 20 (1995), S. 101-105 
    Details
    ISSN: 1432-0509
    Schlagwort(e): Stomach, polyposis ; Stomach, fundic gland polyp ; Stomach, cystic hamartomatous polyp ; X-ray examination, endoscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background: Assessments were made of 63 cases of fundic gland polyposis (FGP) unassociated with adenomatosis coli. These cases were evaluated by radiological examination over 2 years follow-up. All polyps were pathologically confirmed by endoscopic biopsies. Methods: Most cases were asymptomatic when diagnosed during mass radiological surveys of the upper gastrointestinal tract. The majority of patients ranged in age from 40–60 years, and the polyps numbered fewer than 20 in 55 cases (87.3%). Polyps were detected in the fundic glands using the congo red test and by biopsies. Results: All serum gastrin values were within the normal range. During the course of this study, the polyps of 13 cases (20.6%) increased and those of three cases (4.8%) decreased or resolved completely. Conclusion: From these findings it is considered that FGP are observed in stomachs with less atrophy, and that polyps follow courses in which they increase, decrease, disappear, along with atrophy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00201512
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Preferential replication-dependent mutagenesis in the lagging DNA strand inEscherichia coli (1996)
    Springer
    Molecular genetics and genomics 251 (1996), S. 657-664 
    Details
    ISSN: 1617-4623
    Schlagwort(e): Asymmetrical mutagenesis ; dnaQ49 ; mutator ; Preferential lagging strand mutagenesis ; Frameshift reversion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The mutation frequencies attributable to −1 frameshift or one-base substitution in the structural genes coding for resistance to chloramphenicol (Cm) and tetracycline (Tc) were followed over several cycles of DNA replication, and found to differ several-fold, depending on the orientation of the gene on the plasmid with respect to the direction of (unidirectional ColE1-type) replication. The mutation frequency was higher when the reporter gene was present in the plasmid in the same orientation as the direction of the origin, i.e., when the transcription template is the lagging daughter strand, than when the gene was inserted in the opposite orientation. This significant difference in reversion frequencies of genes with different polarities was demonstrated only for a brief period of cell growth (several cycles of replication) after induction of thednaQ49 mutator, but was not observed when an increased number of replication cycles, was permitted, most probably due to fixation of the mutation into both strands. The mutated intermediate DNA which possesses a misaligned basepair in the Cm gene was demonstrated to be replicated into two progeny DNA molecules; one is the chloramphenicol-resistant (CmR) DNA synthesized from the template strand having the mutation and the other is the Cms DNA from the template strand without mutation. Our results suggest that replication-dependent mutagenesis may occur preferentially in the lagging strand.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02174114
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