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Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1 a mother and a homozygous HPA-1 b father (1994)

Moser, R. ; Fae, I. ; Neumeister, A. ; [weitere]

Springer

European journal of pediatrics 153 (1994), S. 95-97

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Details

ISSN: 1432-1076

Schlagwort(e): Key words: Neonatal allo-immune thrombocytopenia – HPA-1 b – HLA class-I and class-II molecules

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract. We report a case of neonatal allo-immune thrombocytopenia due to fetomaternal human platelet antigen (HPA)-1 incompatibility. Anti-HPA-1 b antibodies were detectable in maternal serum. Repeated treatment of the infant with high-dose IgG effectively raised platelet counts transiently, but the patient remained thrombocytopenic for more than 6 weeks. Serological and DNA analysis revealed that the mother was homozygous HPA-1 a and the father homozygous HPA-1 b.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01959215

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