ISSN:
0749-1581
Schlagwort(e):
Methotrexate 1H and 13C NMR
;
Relaxation
;
Conformation
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
1H and 13C NMR parameters of methotrexate in [2H6]dimethyl sulphoxide were obtained and analysed in terms of a ‘preferred’ conformation. The effective correlation time of the anisotropic motion of the pteridinylbenzoyl moiety was evaluated as ca. 10 ns at 300 K. The 1H—1H and 13C—1H distances obtained were used to construct the molecular structure in solution.
Zusätzliches Material:
2 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/mrc.1260310502
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