ISSN:
1476-5535
Keywords:
actinomycetes
;
aminoglycoside resistance
;
aminoglycoside-directed screening
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Abstract Wide varieties of multiple aminoglycoside antibiotic (AG) resistance that are not found in knownStreptomyces cultures were found among actinomycetes isolated as AG-resistant. Screening of about 170 AG-resistant isolates demonstrated their high probability (63%) of antibiotic production including the production of eight different AGs. We found specific AG-resistance patterns correlating to the productivity of specific AGs and established an AG-targeted assay system using AG producers as test organisms. Consequently, AG-directed screening totally on the basis of multiple AG-resistance was established. Necessity of biochemical and genetic studies on primary metabolism in order to find a new basis to search for novel metabolites is also discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01574766
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