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  • 1
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 96 (1992), S. 8683-8686 
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1520-5827
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 277 (1976), S. 0 
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    facet.materialart.
    Unbekannt
    Washington : Periodicals Archive Online (PAO)
    Catholic historical review. 81:1 (1995:Jan.) 91 
    ISSN: 0008-8080
    Thema: Geschichte , Theologie und Religionswissenschaft
    Beschreibung / Inhaltsverzeichnis: Modern European
    Notizen: BOOK REVIEWS
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Zeitschrift für Herz-, Thorax- und Gefässchirurgie 12 (1998), S. 130-134 
    ISSN: 0930-9225
    Schlagwort(e): Schlüsselwörter Infrarenales Aortenaneurysma – endovaskuläre Prothese – Halsregion – Fußpunktregion ; Key words Infrarenal abdominal aortic aneurysm, endovascular prostesis – proximal neck – distal neck
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary In view of a possible Stent implantation, 20 infrarenal abdominal aneurysms obtained consecutively during postmortem examinations were investigated. Measurements were performed according to toporegional criteria on the proximal and distal necks of the aneurysms as well as on their lengths and diameters. Then we correlated the extent of the proximal and distal necks to the aneurysmal lengths and diameters, respectively. The following results were obtained: 1. Depending on the increase in length of the infrarenal abdominal aneurysm, there is an inproportional shortening of the proximal and distal neck. Up to an aneurysmal length of 4 cm both proximal and distant necks are suitable for stent fixation in all cases. 2. With lengths of more than 4 cm according to the morphological results, the distal neck is almost always unsuitable for fixation of a simple Tube-Stent. 3. The proximal neck is suitable for stent fixation in all cases up to an aneurysmal length of 10 cm. For longer aneurysms, only a quarter of all cases is suitable for stent implantation. In all cases investigated there were severe arteriosclerotic changes with atheromatous ulcerations and secondary wall-adherent thrombi of up to three centimeter thickness in the aneurysmal and para-aneurysmal regions. These findings have to be considered, with respect to the transluminal transport of the prosthesis as well as in the regions of the supposed implantation in the proximal and distal necks of the aneurysm with individually variable arteriosclerotic changes of the aorta.
    Notizen: Zusammenfassung Im Hinblick auf eine mögliche Stentimplantation wurden in 20 aus dem laufenden Obduktionsgut gewonnenen infrarenalen Aortenaneurysmen nach toporegionalen Kriterien Längenmaße für die proximale Halsregion und distale Fußpunktregion erhoben. Es wurden diese mit den Aneurysmenlängen bzw. Aneurysmendurchmessern korreliert. Folgende Ergebnisse wurden erzielt: 1. Abhängigkeit der Längenzunahme infrarenaler Aorteneurysmen resultieren unproportionale Verkürzungen der Hals- und Fußpunktregionen. Bis zu einer Aneurysmenlänge von 4 cm sind die proximale Hals- und die distale Fußpunktregion in allen Fällen zur Verankerung eines Stents geeignet. 2. Ab einer Aneurysmenlänge von mehr als 4 cm ist nach den morphologischen Befunden die distale Fußpunktregion so gut wie immer zur Fixierung eines einfachen Rohrstents unzureichend. 3. Die proximale Halsregion ist bis zu einer Aneurysmenlänge von bis zu 10 cm grundsätzlich in allen Fällen zur Verankerung des Stents geeignet, ab dieser Länge jedoch nur noch in einem Viertel der Fälle 4. In allen untersuchten Aneurysmen konnten schwergradige arteriosklerotische Veränderungen mit atheromatösen Wandaufbrüchen und sekundär anhaftenden Thromben, bis zu einer Dicke von drei cm nachgewiesen werden. Diese Befunde müssen sowohl beim transvasalen Transport der Prothese, als auch in den Regionen der angestrebten Implantation der Hals- und Fußpunktregion der individuell variabel arteriosklerotisch veränderten Aorten berücksichtigt werden.
    Materialart: Digitale Medien
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  • 6
    ISSN: 1432-0851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of cell-free ascitic fluid from patients with epithelial ovarian carcinoma on the generation of lymphokine-activated killer cells (LAK) was compared to the activity generated in control medium containing 10% fetal bovine serum, using Daudi target cells. Samples of ascitic fluid from nine different patients tested inhibited LAK generation. Suppressive activity was evident as early as 24 h of incubation in the presence of ascitic fluid and increasing suppression developed with prolonged exposure. Suppression was concentration-dependent, present at 10%–20% and increasing with concentrations up to 80%. The suppressive effect of ascitic fluid was only partially reversed on increasing the concentration of interleukin-2 (IL-2) from 10 units to 1000 units/ml. Activated LAK appeared to maintain the majority of their activity on further culture in ascitic fluid in the presence of IL-2 but further enhancement of lytic activity was prevented. Fractionation of a suppressive sample by HPLC, using 0.1 M KCl/acetic acid buffer pH 2.6, revealed that the dominant peak of suppressive activity eluted at 25 kDa; with pH 7.0 TRIS-buffered saline, most of the activity was lost on the column. Antibody neutralization studies of the 25-kDa suppressive peak as well as on whole ascitic fluid have revealed that transforming growth factor β (TGFβ) is the major suppressive factor present in ascitic fluid. Factors that suppress LAK generation in vitro were present in all samples tested. The effect on the lytic activity of activated LAK cells was minimal. This suggests that, in the clinical setting, the greatest impact would be achieved by activating LAK cells ex vivo and subsequently transferring them to the peritoneal cavity in the presence of IL-2 rather than by attempting to generate them in situ by injecting IL-2 into the peritoneal cavity. However, reversal of TGFβ-mediated suppression in situ may be necessary to allow local proliferation of LAK cells to achieve an effective killer-totarget ratio.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Archives of gynecology and obstetrics 7 (1875), S. 552-556 
    ISSN: 1432-0711
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    The annals of regional science 32 (1998), S. 201-219 
    ISSN: 1432-0592
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie , Wirtschaftswissenschaften
    Notizen: Abstract.  This paper deals with the question, whether in a federal state the regions should obtain the right to levy regional income taxes. It is shown that a revenue sharing system influences the optimal income tax rates and causes distortions. In a federal system with other distorting taxes, several states and a revenue sharing system the welfare effects of regional income taxes can be positive or negative due to second best problems. Therefore the welfare effects of regional income taxes are computed by means of an interregional computable general equilibrium analysis (CGE). The results suggest that in the German federal economy the sign of the welfare effects of the introduction of regional income taxes is very sensitive to the particular institutional arrangements.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Polymer bulletin 12 (1984), S. 287-292 
    ISSN: 1436-2449
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Summary Using the method of hot drawing developed earlier, an attempt has been made to obtain ultra-high modulus and ultrahigh strength PE filaments from original filaments produced by the “surface growth” technique. The average tensile strength of the drawn fibers reaches 5.5 GPa and the value of modulus measured in a dead loading creep experiment is estimated to be 44 GPa. 13 % of the drawn specimens had extremely high tensile strength close to theoretical estimates. The great scatter of the tensile strength data is attributed to the kink-band formation in the specimens due to their bending during preparation or during drawing.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    ISSN: 1569-8041
    Schlagwort(e): dosing ; inhibitor ; matrix metalloproteinase ; pharmacokinetics ; solid tumours ; toxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background:This phase I study was performed to evaluatethe safety, tolerability, and efficacy of the oral matrixmetalloproteinase inhibitor BAY 12-9566 in patients with advanced solidtumours, and to identify the maximum tolerated dose and dose for use insubsequent studies. Patients and methods:BAY 12-9566 was administered to 29 patientsat doses ranging from 100 mg o.d. to 1600 mg (given either 400 mg q.i.d. or800 mg b.i.d.). Blood samples for pharmacokinetic analyses were drawn on days1–5, day 15 and days 29 and 30. Patients were continued on daily oraltreatment of BAY 12-9566 until a dose limiting toxicity or tumour progressionoccurred. Results:A maximum tolerated dose was not defined because plasmalevels of BAY 12-9566 could not be sufficiently increased, even withescalating doses of drug. Pharmacokinetic analysis suggested that absorptionwas saturable at higher doses. The predominant toxicities related to drug wereasymptomatic reversible effects on platelets and transaminases and mildanemia. There were no significant musculoskeletal toxicities. No objectiveresponses were seen at the doses tested, but stable disease was observed insome patients based on tumour measurements. Conclusions:The recommended dose of BAY 12-9566 for furtherstudies is 800 mg b.i.d. as this dose provides maximal plasma levels that canbe achieved with a convenient dosing schedule for a chronically administeredoral agent
    Materialart: Digitale Medien
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