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  • 1
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    Stochastic Optimization for Operating Chemical Processes Under Uncertainty (2001)
    Details
    Publikationsdatum: 2021-02-01
    Beschreibung: Mathematical optimization techniques are on their way to becoming a standard tool in chemical process engineering. While such approaches are usually based on deterministic models, uncertainties such as external disturbances play a significant role in many real-life applications. The present article gives an introduction to practical issues of process operation and to basic mathematical concepts required for the explicit treatment of uncertainties by stochastic optimization.
    Schlagwort(e): ddc:000
    Sprache: Englisch
    Materialart: reportzib , doc-type:preprint
    Format: application/postscript
    Format: application/pdf
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  • 2
    Digitale Medien
    Digitale Medien
    Differential expression of RAB5A in human lung adenocarcinoma cells with different metastasis potential (1999)
    Springer
    Clinical & experimental metastasis 17 (1999), S. 213-219 
    Details
    ISSN: 1573-7276
    Schlagwort(e): gene expression ; immunohistochemistry ; mRNA DD ; neoplasia metastasis ; RAB5A
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract For the sake of better understanding the molecular mechanism of neoplasia, we have used the mRNA differential display technique to analyze two human lung adenocarcinoma cell lines, AGZY83-a and Anip973. Anip973 was isolated from AGZY83-a, but manifested much higher metastatic potential than the parent line. We found that a significant differential cDNA fragment in Anip973 was over-expressed, then over-expressed cDNA fragment was cloned and sequenced. It showed that the over-expressed cDNA in Anip973 was RAB5A cDNA. And the RAB5A cDNA sequence was corresponding between the two cells. To determine whether RAB5A may be differentially expressed in the two human lung adenocarcinoma cells at protein level, we further detected RAB5A protein in the two cells by using immunofluorescent method. RAB5A protein was upregulated in highly metastatic Anip973. We also detected the difference in RAB5A gene expression at RNA level in human non-small cell lung carcinoma by RT-PCR. Using immunohistochemical staining, we also examined RAB5A change at protein level in 45 cases human non-small cell lung carcinoma paraffin sections. The results proved the evidence of upregulation of RAB5A in malignant tumor, indicated over-expression of RAB5A gene was correlated with the malignant degree and metastatic potential of lung cancer(χ2 test, p 〈0.01). The RAB5A gene is a member of RAS superfamily, which can transcribe GTP-binding protein that plays an important role in signal transduction of protein trafficking at the cell surface and GDP/GTP cycle in the regulation of endocytotic membrane traffic. Thus our results indicated that over-expression of the RAB5A gene was involved in the process of transformation from AGZY83-a to the higher metastatic cell line Anip973. The result may be a powerful experimental evidence that over-expression of RAB5A gene associated with neoplasia metastasis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006617016451
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  • 3
    Digitale Medien
    Digitale Medien
    91. Dynamische Optimierung thermischer Trennverfahren (1998)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 70 (1998), S. 1130-1130 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Industrial Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330700993
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  • 4
    Digitale Medien
    Digitale Medien
    Analyse und Anwendung dynamischer Optimierungsalgorithmen für Batch-Prozesse (1996)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 68 (1996), S. 382-389 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Industrial Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Batch processes being increasingly used in the chemical industry. The advantages of batch processes are their flexibility, high product purity and the possibility of frequent product changeover. For the economical operation of a batch process it is necessary to develop an optimal strategy; therefore a proper optimisation approach is required. For this reason two different optimisation algorithms, differential dynamic programming and a simultaneous optimisation approach, are investigated in this paper. The characteristics of the algorithms are worked out and their efficiency is analysed. Simulation results from batch reactors and a batch column demonstrate the scope of application of the algorithms.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330680404
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  • 5
    Digitale Medien
    Digitale Medien
    Modellgestützte Entwicklung einer zeitoptimalen Produktwechselstrategie für RektifikationskolonnenVortrag anläßlich der GVC-Jahrestagung, 25./27. September 1996 in Dortmund. (1997)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 69 (1997), S. 827-830 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Industrial Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330690614
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  • 6
    Digitale Medien
    Digitale Medien
    The Tautomerism between Ketene Aminals and Amidines (1990)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 332 (1990), S. 1035-1040 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A tautomerie equilibrium between ketene aminals and amidines is disclosed as an electron-donating group is substituted at the para-position of the phenyl ring in 4.
    Zusätzliches Material: 4 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19903320621
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