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  • 1
    Digitale Medien
    Digitale Medien
    Sex differences in mucosal response to Helicobacter pylori infection in the stomach and variations in interleukin-8, COX-2 and trefoil factor family 1 gene expression (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Gastric cancer incidence in men is almost double that in women. We investigated mucosal responses in the stomach against Helicobacter pylori (H. pylori) infections to elucidate the interindividual or sex-related differences, which may in turn be associated with gastric cancer incidence, mucosal changes of stomach as measured by the Sydney System, and interleukin-8, cyclooxygenase-2 and trefoil factor family 1 (TFF1) gene expression.Methods : An age-, sex-, H. pylori status- and disease-matched case−control study was performed in 574 H. pylori-positive and 225 H. pylori-negative patients selected from 4125 patients with a diagnosis of benign disease of the stomach. Levels of acute and chronic inflammations, atrophy and intestinal metaplasia scored according to the Sydney System were compared by stomach site and by sex. Two biopsy specimens (antral and corpus gastric mucosa) from patients with benign gastric diseases (142 patients; 72 men, 70 women) were analysed for interleukin-8, cyclooxygenase-2 and TFF1 mRNA expression as measured by real-time PCR.Results : Inflammation and activity scores in antrum with H. pylori infection were higher in men, but scores declined according to age. Atrophy and intestinal metaplasia scores in corpus with H. pylori infection appeared more severe in men than in women, especially in older patients. In women, atrophy score increased with increasing age, particularly in postmenopausal H. pylori-negative patients. Interleukin-8 mRNA induction was detected in both antrum and corpus mucosa in H. pylori infection, but sex differences were not found. Response of cyclooxygenase-2 mRNA expression against H. pylori infection in the mucosa was higher in men than women. In H. pylori-negative patients, TFF1 mRNA levels in women were significantly higher than in men, and TFF1 mRNA was significantly lower in positive than negative women.Conclusions : Sex differences in mucosal responses to H. pylori infection in the stomach may be correlated with sex differences in the incidence of stomach cancer.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.01985.x
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  • 2
    Digitale Medien
    Digitale Medien
    Diagnostic value of culture, histology and PCR for Helicobacter pylori in the remnant stomach after surgery (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 20 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background : Diagnosis of Helicobacter pylori infection in the remnant stomach has not been established.Aims : To investigate the diagnostic value of culture, histology, PCR and serum IgG against H. pylori (ELISA) with and without eradication therapy in the remnant stomach, compared with the unoperated stomach.Methods : Biopsy samples for bacterial culture and histological diagnosis of H. pylori were taken from the stoma and upper corpus of the remnant stomach and gastric juice was used for PCR assay.Results : Bacterial culture-based diagnosis in the remnant stomach, sensitivity and specificity of culture were 95.1%, 100%; histology 89%, 92.3%; PCR 66%, 89.7%; and ELISA 100%, 50%, respectively, in cases without H. pylori eradication therapy. In assessment of the results of therapy for the remnant stomach, sensitivity and specificity of culture were 100%, 100%; histology 80%, 96.8%; PCR 80%, 91.7%; and ELISA 100%, 0%, respectively.Conclusion : Bacterial culture had the highest diagnostic value in the remnant stomach as well as unoperated stomach. Sensitivity by histology and PCR was lower in the remnant stomach than the unoperated stomach, but specificity values were equal. Serum ELISA assay was not suitable for the remnant stomach.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.01989.x
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  • 3
    Digitale Medien
    Digitale Medien
    Microstructure of Bi"2(Sr,Ca)"3Cu"2O"x/Bi"2Sr"2CuO"x/Bi"2(Sr,Ca)"3Cu"2O"x multilayer films fabricated by ion beam sputtering
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 185-189 (1991), S. 2059-2060 
    Details
    ISSN: 0921-4534
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Physik
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4534(91)91154-V
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  • 4
    Digitale Medien
    Digitale Medien
    Mutagens in foods, and their production by cooking
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 54 (1978), S. 216 
    Details
    ISSN: 0165-1161
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1161(78)90055-9
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  • 5
    Digitale Medien
    Digitale Medien
    On mutagens in foods, especially on compounds from pyrolysis of protein
    Amsterdam : Elsevier
    Mutation Research/Environmental Mutagenesis and Related Subjects 53 (1978), S. 238-239 
    Details
    ISSN: 0165-1161
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-1161(78)90300-X
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  • 6
    Digitale Medien
    Digitale Medien
    Induction of liver tumors in rats by sodium nitrite and methylguanidine (1977)
    Springer
    Journal of cancer research and clinical oncology 90 (1977), S. 87-94 
    Details
    ISSN: 1432-1335
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The carcinogenicity of sodium nitrite and methylguanidine singly and together were examined in rats. A hepatocellular carcinoma, a hemangiosarcoma and a spindle cell sarcoma were found in 3 of 15 rats fed continuously on pellet diet containing 0.16% sodium nitrite and 0.16% methylguanidine. Hemangiomas and bile duct adenomas of the liver were also found in 6 and 8, respectively, of the 15 rats in this group. Hemangiomas and bile duct adenomas of the liver were found in 2 and 3, respectively, of the 4 rats fed on pellet diet containing 0.16% sodium nitrite. Only 1 of 5 rats fed on pellet diet containing 0.16% methylguanidine developed a hemangioma. No tumor was found in the control group. All the tumors were found in rats that survived for over 12 months. No significant changes were detected in the esophagus or stomach.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00306023
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  • 7
    Digitale Medien
    Digitale Medien
    Intestinal metaplasia and adenocarcinoma induced in the stomach of rats by N-propyl-N′-nitro-N-nitrosoguanidine (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 201-206 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Intestinal metaplasia ; Gastric carcinoma N-Propyl-N′-nitro-N-nitrosoguanidine ; Wistar rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary PNNG, the propyl derivative of MNNG, was administered to Wistar rats at a concentration of 59.5 μg/ml in the drinking water for 4, 8, and 12 months and the rats were killed in the 15th month. Intestinal metaplasia was induced in the glandular stomachs of 25%, 75%, and 83% of the rats treated with PNNG for 4, 8, and 12 months, respectively. Metaplastic glands were found in the pyloric region, especially near the pyloric ring. These glands contained goblet cells and columnar cells with striated borders. No tumors were found in the stomach of rats after 4-months treatment, but adenomas were found after 8-months treatment, and both adenomas and adenocarcinomas after 12-months treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00422498
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  • 8
    Digitale Medien
    Digitale Medien
    Promoting action of croton oil on gastrocarcinogenesis by N-methyl-N′-nitro-N-nitrosoguanidine in rats (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 323-327 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Croton oil ; Tumor promotion ; Gastrocarcinogenesis ; Wistar rat ; Crotonöls ; Tumor-Promotion ; Magencarcinogenese ; Wistar-Ratte
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die tumorfördernde Wirkung des Crotonöls für die Magencarcinogenese mit MNNG wurde an männlichen Wistar-Ratten untersucht. Bei fünf von 10 Ratten wurden Magencarcinome beobachtet, wobei zuerst während drei Monaten 83 μg/ml MNNG und dann 0.02% Crotonöl, gelöst in 0,5% Tween 60, neun Monate lang verabreicht wurden. Bei Ratten, die drei Monate lang mit MNNG und danach neun Monate lang mit Tween 60 allein behandelt wurden, sind keine Magencarcinome beobachtet worden. Das Auftreten von Magencarcinomen in diesen zwei Gruppen war demnach signifikant unterschiedlich (p〈0.05). Bei Ratten, denen nur Crotonöl mit Tween 60 verabreicht wurde, sind keine Geschwülste beobachtet worden.
    Notizen: Summary The promoting effect of croton oil on gastrocarcinogenesis by MNNG was examined in male Wistar rats. Gastric carcinomas were found in five of 10 rats given 83 μg/ml MNNG for three months and then 0.02% croton oil with 0.5% Tween 60 as solvent for nine months. No gastric carcinomas were found in rats given MNNG for three months and then Tween 60 only for nine months. The incidence of gastric carcinomas in these two groups was significantly different (p〈0.05). No tumors were found in rats given only croton oil with Tween 60.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00964588
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  • 9
    Digitale Medien
    Digitale Medien
    Sequential studies on the histopathogenesis of gastric carcinoma in rats by a weak gastric carcinogen, N-propyl-N′-nitro-N-nitrosoguanidine (1980)
    Springer
    Journal of cancer research and clinical oncology 98 (1980), S. 153-163 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Gastric carcinoma ; Intestinal metaplasia ; N-Propyl-N′-nitro-N-nitrosoguanidine ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen, N-propyl-N′-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 μg/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Rats were killed at intervals between week 1 and week 88. No marked atrophy or ulceration of the mucosa was found between week 1 and the end of the experiment. Focal intestinal metaplasia was found in week 19 and its incidence increased during the experiment. Adenocarcinoma in situ with extreme cellular atypia was found in mucosa with a normal appearance in week 67. An adenocarcinoma invading the submucosa was found in week 69, and one invading the serosa in week 88. All these pathological lesions were found on the anal side of the pyloric region. No pathologic changes were found in the fundic region. The sequential changes of the mucosa of the glandular stomach induced by this weak gastric carcinogen, PNNG, were very different from those induced by the potent gastric carcinogen, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Gastric carcinoma induced by PNNG seems to be more similar to human gastric cancer than that induced by MNNG.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00405959
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