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  • 1
    Digitale Medien
    Digitale Medien
    Inhibition of Neutral Sphingomyelinase Activation and Ceramide Formation by Glutathione in Hypoxic PC12 Cell Death (1999)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 73 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract : Reduced glutathione (GSH) and N-acetylcysteine (NAC), but not other antioxidative or reducing agents, were found to inhibit cell death, both apoptosis and necrosis, induced by hypoxia in naive and nerve growth factor-differentiated PC12 cells. The level of intracellular total GSH decreased time-dependently during hypoxia, but exogenously added GSH prevented such a decrease in GSH. Pretreatment of cells with exogenous GSH or NAC resulted in inhibition of both neutral sphingomyelinase (SMase) activation and ceramide formation during hypoxia. In the in vitro assay system, neutral SMase activity was inhibited dose-dependently by GSH and NAC. Activation of caspase-3 induced by hypoxia was also inhibited by either GSH or NAC. NAC but not GSH inhibited caspase-3 activation induced by C2-ceramide. These results suggest that GSH protects cells from hypoxic injury by direct inhibition of neutral SMase activity and ceramide formation, resulting in inhibition of caspase-3 activation, and that NAC exerts an additional inhibitory effect(s) downstream of ceramide.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0730675.x
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  • 2
    Digitale Medien
    Digitale Medien
    Changes in the Activity and mRNA Levels of Phospholipase D During Ceramide-Induced Apoptosis in Rat C6 Glial Cells (1997)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 69 (1997), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: N-Acetylsphingosine (C2-ceramide), a membrane-permeable analogue, induced apoptosis in C6 glial cells. Phase-contrast micrographs showed that the round cells appeared 3 h after exposure to 25 µM C2-ceramide and the number of floating cells increased time-dependently. Staining with Hoechst 33258 dye showed condensed or fragmented nuclei in round cells at 12 h. DNA fragmentation was also observed by agarose gel electrophoresis at 12 h. To understand the mechanism underlying glial cell death induced by C2-ceramide treatment, changes in phospholipase D (PLD) activity in response to guanosine 5′-O-(3-thiotriphosphate) (GTPγS) and expression of mRNA levels of PLD isozymes were examined. In cell lysate, GTPγS-dependent PLD activity was down-regulated after ceramide treatment in a time-dependent manner. In the in vitro PLD assay, membrane-associated PLD activation in response to recombinant ADP-ribosylation factor 1 was greatly suppressed. Furthermore, levels of rPLD1a and rPLD1b mRNAs were found to be down-regulated, whereas the level of rPLD2 mRNA increased gradually, peaking at 3 h, followed by a slow decrease, as inferred by reverse transcription-polymerase chain reaction. Decreases in GTPγS-dependent PLD activity were well correlated with those in rPLD1a and rPLD1b mRNAs levels. Taken together, these data suggest that levels of PLD enzymes might be decreased by ceramide treatment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1997.69020713.x
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  • 3
    Digitale Medien
    Digitale Medien
    Power and temperature distribution during microwave thawing, simulated by using Maxwell's equations and Lambert's law (2005)
    Oxford, UK : Blackwell Science Ltd
    International journal of food science & technology 40 (2005), S. 0 
    Details
    ISSN: 1365-2621
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: The microwave thawing of frozen food was simulated by using an equation to describe heat conduction. This was based on the fact that the thermal and dielectric properties of food vary with temperature. The microwave power absorbed was modelled by using Maxwell's equations and Lambert's law. The power and temperature distributions calculated using both models were compared. Although Lambert's law is theoretically less applicable for simulating the transmitted microwave power, it provided an effective numerical approach for calculating temperature distribution during microwave thawing, which proved compatible with experimental results.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.2004.00904.x
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  • 4
    Digitale Medien
    Digitale Medien
    Two Dimensional Simultaneous Heat and Moisture Transfer in Composite Food (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 57 (1992), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A computerized method was developed to predict two dimensional, simultaneous heat and moisture transfer in a composite food with chemical reactions, based on the use of the chemical potential as the mass transfer potential. Thermodynamically interactive heat and mass fluxes were included in the mathematical model. Composite cylindrical samples in three layers prepared from a high amylose starch granule hydrate and a mixture of the same dhydrate and sucrose were dried in a forced air dryer to experimentally verify values predicted by the computerized method. The central temperatures and average moisture contents of the samples determined experimentally, agreed well with those predicted theoretically.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.1992.tb05520.x
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  • 5
    Digitale Medien
    Digitale Medien
    Heat and Moisture Transfer in Composite Food—Theoretical Analysis of Influence of Surface Conductance and Component Arrangement (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 58 (1993), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Heat and moisture transfer in composite bodies undergoing drying was simulated using a previously developed mathematical model which included the chemical potential of moisture as a mass transfer potential. Composite bodies included layered cylinders and concentric spheres consisting of a starch granule hydrate (H) and a hydrate of starch granules-sucrose 3:l mixture (S). The influence of the following factors on heat and moisture transfer was examined: convective surface mass transfer conductance, initial moisture, and component arrangement. The three factors significantly influenced moisture transfer white they had slight influence on heat transfer. Overall drying rate of each composite body was infhrenced interactively by moisture fluxes, which were caused by a surrounding drying medium and by a mass transfer potential difference across the interface of H and S.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.1993.tb06178.x
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  • 6
    Digitale Medien
    Digitale Medien
    Computerized Model for Strain-Stress Analysis of Food Undergoing Simultaneous Heat and Mass Transfer (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 56 (1991), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A computerized method was developed for simulating transient state heat and moisture transfer and stress distribution in axisymmetric food undergoing drying process. For this development, a simultaneous heat and moisture transfer model was coupled with the virtual work principle applicable to a body undergoing volumetric changes. The developed method was verified by comparing experimental results with those predicted. Experimental results were obtained by drying cylindrically formed samples of hydrated starch granules. They included central temperature, average concentration histories and photographically observed internal crack formations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.1991.tb04792.x
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  • 7
    Digitale Medien
    Digitale Medien
    Expression of the placental form of glutathione S-transferase in pediatric gliomas (1993)
    Springer
    Child's nervous system 9 (1993), S. 142-146 
    Details
    ISSN: 1433-0350
    Schlagwort(e): Glutathione S-transferase ; placental form ; Pediatric glioma ; Immunohistochemistry ; Western blotting
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Expression of the human placental form of glutathione S-transferase (GST-θ) in pediatric gliomas, consisting of three pilocytic astrocytomas (grade 1), two fibrillary astrocytomas (grade 2), three anaplastic astrocytomas (grade 3), and one glioblastoma multiforme (grade 4), were investigated by immunohistochemical methods. Western blot analysis for GST-θ using proteins extracted from formalin-fixed and paraffin-embedded glioma specimens was performed and compared with the results of immunohistochemistry. Both the immunohistochemical examination and the Western blot analysis of pediatric gliomas revealed that malignant gliomas such as anaplastic astrocytoma and glioblastoma had strong expression of GST-θ while benign gliomas showed weak GST-θ expression.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00272262
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  • 8
    Digitale Medien
    Digitale Medien
    Histochemistry with Helix pomatia agglutinin in human germ cell tumors: detection of nongerminomatous components and correlation between HPA reactivity and radiosensitivity in germinomas (1993)
    Springer
    Child's nervous system 9 (1993), S. 266-270 
    Details
    ISSN: 1433-0350
    Schlagwort(e): Lectin ; Helix pomatia ; Human germ cell tumors ; Radiosensitivity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Binding sites of Helix pomatia agglutinin (HPA) were examined in 32 patients with intracranial human germ cell tumors. HPA reactivity was found in vascular endothelial cells and erythrocytes of patients with blood type A or AB. HPA-positive neoplastic cells were seen in one yolk sac carcinoma in a patient with blood group. A, and in embryonal carcinomas and teratomas irrespective of blood group type. Although in 10 out of 18 germinomas neoplastic cells were totally negative for HPA, another 8 germinomas showed HPA-positive neoplastic cells which were distributed sporadically or in an area and independent of blood group types. HPA-negative germinoma patients showed a very good response to radiotherapy, whereas 4 out of 8 HPA-positive tumors showed poor radiosensitivity, with a residual lesion seen on computed tomography even after the total radiation dose of 40–50 Gy. These findings suggest that HPA-positive neoplastic cells in germinomas indicate components of differentiation of non-germinomatous germ cells. HPA-positive germinomas might be less radiosensitive than HPA-negative germinomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00306269
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  • 9
    Digitale Medien
    Digitale Medien
    Long-term survival in malignant intracranial germ-cell tumors: a report of two cases and a review of the literature (1993)
    Springer
    Child's nervous system 9 (1993), S. 431-436 
    Details
    ISSN: 1433-0350
    Schlagwort(e): Germ cell tumor ; Yolk sac tumor ; Embryonal carcinoma ; Cisplatin ; Long-term survival
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The authors report the successful treatment of two cases of malignant germ-cell tumor. A 12-year-old patient with a pineal immature teratoma and increase of α-fetoprotein serum levels was treated with total excision and cisplatin, vinblastine, and bleomycin (PVB) in combination given twice. One year later, he had a recurrence of tumor in the right occipital lobe, which was totally removed, and yolk sac tumor was verified. As subsequent adjuvant chemotherapy, PVB was given in four courses over 1.5 years, together with one course of cisplatinetoposide (PE) therapy. The patient is well 5 years and 9 months after the first operation. In the second case, a 19-year-old patient with a pineal mixed germ-cell tumor, composed of germinoma, yolk sac tumor, and embryonal carcinoma, was treated with total excision, followed by four courses of PVB therapy and one of PE. She has done well in the 4.5 years since the initial treatment. Thus, aggressive extirpation of the lesion and subsequent combination chemotherapy using cisplatin and other multiple drugs, given in at least four courses over 1.5 years, even if tumor markers return to within normal limits, might provide successful treatment for malignant germ-cell tumors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00306201
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  • 10
    Digitale Medien
    Digitale Medien
    Distribution of cellular carbohydrate moieties in human dysontogenetic brain tumors, especially in craniopharyngioma and epidermoid/dermoid (1992)
    Springer
    Acta neuropathologica 85 (1992), S. 71-78 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Cellular carbohydrate moietie ; Lectin ; Craniopharyngioma ; Epidermoid/dermoid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Cellular carbohydrate moieties of 65 human dysontogenetic brain tumors (craniopharyngioma, epidermoid/dermoid, Rathke cleft cyst, germinoma and non-germinomatous germ-cell tumors) and 60 common brain tumors (glioma, meningioma, neurinoma and pituitary adenoma) were investigated histochemically using lections from Ulex europaeus (UEA-1), Dolichos biflorus (DBA), peanut (PNA) and soybean (SBA), and with anti-blood group A and LewisY (LeyY) antibodies. In craniopharyngiomas and epidermoid/dermoids, it was found that PNA and SBA binding sites existed in suprabasal cells of the epithelium, and that antigen of either blood group A or H (demonstrable by UEA-1) existed in more differentiated epithelial cells compared to the results reported in normal human skin epidermis. Rathke cleft cysts were stained with PNA or SBA, and two out of three Rathke cleft cysts also expressed either H or A antigen. In addition, DBA binding sites, as well as LeY antigen, were frequently seen in craniopharyngiomas and Rathke cleft cysts, but they were entirely absent in the epithelium of epidermoid/dermoid. On the other hand, PNA and SBA reactivities was also found in common brain tumors, while blood group A, H and LeY antigens and DBA reactivity were almost absent in these tumors. These findings demonstrate that carbohydrate moieties such as those of blood group antigens reported to be found in human skin epidermis exist in a similar form in craniopharyngioma, epidermoid/dermoid and the Rathke cleft cyst. The identification of blood group A, H and LeY antigens and DBA reactivity in brain tumors seems to be considerably limited and specific. Thus, carbohydrate antigen reacting with DBA and the presence of LeY antigen might be distinguishing markers for craniopharyngioma as well as Rathke cleft cyst versus epidermoid/dermoid.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00304635
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