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  • 1
    Digitale Medien
    Digitale Medien
    Pattern of gentamicin-induced cochlear degeneration in the guinea pig (1982)
    Springer
    European archives of oto-rhino-laryngology and head & neck 236 (1982), S. 173-184 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Gentamyzin-induzierte Kochleadegeneration ; Degenerationspunkt ; Vakuolisierung der Reissnerschen Membran ; Elektrokochleographie ; Gentamicin-induced cochlear degeneration ; Degeneration point ; Reissner's membrane vacuolization ; Skin-electrode-evoked response audiometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Gentamicin-induced cochlear degeneration in the guinea pig was studied by complete hair-cell counting (cytocochleograms) and phase-contrast and interference microscopical examination of the stria vascularis and Reissner's membrane. Gentamicin (100 mg/kg/day) was administered over a period of 7–17 days. The first loss of hair cells (OHC) occurred in a region 6–8 mm from the round window. From this ‘degeneration point’, the loss of haircells progressed towards the round window (fast) and the apex (slowly). The stria vascularis showed no signs of degeneration. Reissner's membrane, on the other hand, showed intracellular vacuolization of the endolymphatic cells over the complete length of the cochlea after 12 or more days' intoxication. Hearing loss was measured by electrocochleography with skin electrodes. The histologic findings were compared with the objective audiograms.
    Notizen: Zusammenfassung Die durch Gentamyzin verursachte Degeneration in der Kochlea des Meerschweinchens wurde mit dem Zytokochleogramm sowie mit Phasenkontrast- und Interferrenzmikroskopie der Stria vascularis und der Reissnerschen Membran dargestellt. Der erste Haarzellenverlust wurde 6–8 mm vom runden Fenster entfernt festgestellt. Von diesem „Degenerationspunkt“ aus schreitet der Haarzellverlust rasch zum runden Fenster und langsam spitzenwärts fort. In der Stria vascularis war keine Degeneration zu erkennen, aber die Reissnersche Membran zeigte eine intrazelluläre Vakuolisierung der endolymphatischen Zellen. Der Hörverlust wurde mit der Elektrokochleographie bestimmt und mit den histologischen Befunden verglichen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00454037
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  • 2
    Digitale Medien
    Digitale Medien
    The cortitoxic effects of cis-platinum in the guinea pig (1982)
    Springer
    European archives of oto-rhino-laryngology and head & neck 237 (1982), S. 17-26 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Cis-Platin ; Schädigung der äußeren Haarzellen ; Degenerationsmuster ; Hörverlust ; Gewichtsverlust ; Cis-diammine-dichloroplatinum-II (DDP)-induced cochlear degeneration ; Sporadicallyinjured outer hair-cells ; Degeneration pattern ; Hearing loss ; Loss of weight
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary Cis-diammine-dichloroplatinum-II (DDP)-induced cochlear degeneration in the guinea pig was studied by complete hair-cell counting (cytocochleograms) and transmission electron microscopy. The DDP (1.5 mg/kg/day) was administrated over a period of 5–20 days. The degeneration of the organ of Corti started sporadically in almost every outer hair-cell (OHC) with a strong prevelance in the OHC 1 in the basal turn. No distinct starting point for the degeneration of the organ of Corti could be found. It seemed that the ototoxic effects of DDP are rather different from the ototoxic changes due to aminoglycoside antibiotics. This study showed that the animals with hearing loss due to DDP also had a clear loss of body weight. Perhaps DDP induces toxic effects (loss of body weight) which can amplify the ototoxic effects.
    Notizen: Zusammenfassung Untersuchung der Cis-Platin-Wirkung auf das Cortische Organ des Meerschweinchens mittels Zytocochleogramm und Elektronenmikroskopie. Die Schädigung begann stets an den äußeren Haarzellen der Basalwindung. Der Beginn der Degeneration konnte nicht exakt bestimmt werden. Tiere mit Hörverlust zeigten einen Verlust des Körpergewichtes. Vielleicht trägt der letztere zur Verstärkung des ototoxischen Effektes bei.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00453712
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  • 3
    Digitale Medien
    Digitale Medien
    Hearing loss and inner ear changes in a patient suffering from severe gentamicin ototoxicity (1980)
    Springer
    European archives of oto-rhino-laryngology and head & neck 228 (1980), S. 113-121 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Gentamyzin-Ototoxizität ; Hörverlust ; Innenohrveränderungen ; Gentamicin ototoxicity ; Hearing loss ; Inner ear changes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary The long-term histological effects of gentamicin ototoxicity could be studied in a human being in relation to the audiometric impairment. The possible sequence of degeneration of hair cells, supporting cells, nerve fibers, stria vascularis, spiral ganglion cells, and vascular supply is discussed.
    Notizen: Zusammenfassung Die histologischen Veränderungen an der menschlichen Kochlea nach acht Jahre zurückliegender hochdosierter Gentamyzin-Applikation bei an Taubheit grenzender Schwerhörigkeit, werden aufgezeigt. Folge der ototoxischen Wirkung von Gentamyzin ist zunächst eine Zerstörung der Sinneszellen im Cortischen Organ, denen eine solche der Stützzellen folgt. Dann verschwinden die Nervenfasern und die Zellen im Ganglion spirale und letztlich bleibt eine dünne Zellage auf der Basilarmembran. In der Stria vascularis sind dann bei Bildung von Zysten keine Gefäße mehr nachzuweisen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00455338
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  • 4
    Digitale Medien
    Digitale Medien
    A new angiographic technique for asymptomatic hereditary glomus screening (1983)
    Springer
    European archives of oto-rhino-laryngology and head & neck 238 (1983), S. 143-148 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Digitale Gefäßabbildung ; Nichtinvasive Angiographie ; Glomustumor-Screening ; Ambulant ; Digital vascular imaging ; Noninvasive angiography ; Glomus tumor screening ; No hospitalization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary This paper reports the findings of a new noninvasive technique for the study of blood vessels — digital vascular imaging (D.V.I.). A patient suspected of asymptomatic familial glomus tumor was investigated using D.V.I. Two glomus caroticum tumors (one very small) were found with this new technique. The D.V.I. technique allows one to study vascular lesions in the head and neck without hospitalizing the patient. Digital angiography is an important improvement in screening and follow-up of patients with glomus tumors.
    Notizen: Zusammenfassung Vorstellung einer neuen nichtinvasiven Technik zur Untersuchung der Blutgefäße: Digitale Gefäßdarstellung. Sie gestattet eine Untersuchung von Gefäßveränderungen in Kopf- und Halsbereich ohne Stationierung der Patienten. Mit der neuen Methode konnten zwei Tumoren des Glomus caroticum aufgedeckt werden.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00454306
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  • 5
    Digitale Medien
    Digitale Medien
    The importance of high-tone audiometry in monitoring for ototoxicity (1985)
    Springer
    European archives of oto-rhino-laryngology and head & neck 242 (1985), S. 77-81 
    Details
    ISSN: 1434-4726
    Schlagwort(e): High-frequency audiometry ; Ototoxicity ; Early detection ; Cis-platinum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Early detection of ototoxicity is of vital importance in cases in which ototoxic drugs are administered. Ototoxicity as a result of cis-platinum administration is well documented. Auditory damage may be reduced by changes in dose, drugs or methods of treatment. As ototoxicity appears to be most pronounced in the higher frequencies of sound, any changes can be assessed at an earlier stage by using high-frequency audiometry to test patients at frequencies from 8 to 20 kHz. Our present study demonstrates the utility of monitoring auditory function at frequencies higher than conventionally tested in patients receiving cis-platinum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00464411
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  • 6
    Digitale Medien
    Digitale Medien
    Progressive fatal dementia (Creutzfeldt-Jakob disease) in a patient who received homograft tissue for tympanic membrane closure (1990)
    Springer
    European archives of oto-rhino-laryngology and head & neck 247 (1990), S. 199-201 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Homografts ; Creutzfeldt-Jakob disease ; Otologic surgery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We report the case history of a 54-year-old man who developed a fatal neurological disorder 4 years after a succesful tympanoplasty with homograft pericardium. The final diagnosis of this case was Creutzfeldt-Jakob disease. This infectious spongiform encephalopathy is probably caused by a slow virus that can be transmitted by transplantation materials. The possible accidental transmission of Creutzfeldt-Jacob disease by the use of homograft materials in otologic surgery is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00178983
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  • 7
    Digitale Medien
    Digitale Medien
    Vascular patterns of the saccule of the rat: a microcorrosion cast study (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 18-21 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Inner ear ; Vestibular system ; Saccule ; Vascularization ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A scanning electron microscope study of corrosion cast preparations of the vessels of the saccule was carried out in adult rats. This method shows the microvasculature of the saccule in the three-dimensional model. As a result of this technique we have been able to demonstrate a particular microvasculature of the saccule in the rat's inner ear. The main blood supply of the saccule consists of the arterioles coming from the vestibulocochlear artery entering the anterior margin of the macula sacculi. A few branches of the anterior vestibular artery enter the macula sacculi from the superior margin. The saccular vein drains the venous blood from a dense capil lary area underneath the striola to the posterior vestibular vein which eventually ends in the vein of the cochlear aquaduct.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00176942
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  • 8
    Digitale Medien
    Digitale Medien
    First clinical experiences with an implantable bone conduction hearing aid at the University of Amsterdam (1993)
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 69-72 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Bone conduction ; Hearing loss ; Sound amplication ; Transcutaneous implant
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A transcutaneous bone-conduction hearing aid was implanted in 11 patients who were not suitable for transcranial sound amplification. Audiological and surgical selection criteria were followed strictly. One device had to be explanted and minor revision surgery was needed in two cases for skin irritation and scarring. In general the aids were well tolerated but the amplification power of the external device proved to be insufficient in some patients, in whom bone conduction levels were on the borderline of the selection limits.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00179300
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  • 9
    Digitale Medien
    Digitale Medien
    A retrospective study of the hearing results obtained after stapedotomy by the implantation of two Teflon pistons with a different diameter (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 422-424 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Hearing loss ; Otosclerosis ; Stapedectomy ; Teflon ossicular implant ; Audiometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study reports the evaluation of hearing results after implantation of a Teflon piston of a different diameter in cases of otosclerosis requiring stapedotomy. By random selection, a Teflon piston with a shaft diameter of 0.3 mm was inserted in 34 cases and a piston with a shaft diameter of 0.4 mm in 26 cases. A retrospective analysis of the pre- and postsurgery audiological results of these two patient groups was carried out by microcomputer. A repeated statistical measures analysis of variance was used to test and estimate the air-conduction frequency-specific differences between the two prostheses with respect to changes in pre- and postoperative healing. The results of this comparative study of the two Teflon pistons with different diameters indicate statistically a greater hearing gain for the 0.4-mm prosthesis, especially in the lower frequencies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02439972
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  • 10
    Digitale Medien
    Digitale Medien
    Changes in the stria vascularis of the guinea pig due to cis-platinum (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 41-47 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Cis-diamminedichloroplatinum II ; Guinea pig ; Stria vascularis ; Changes in marginal cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The microscopical and ultramicroscopical changes in the stria vascularis due to cis-diamminedichloroplatinum II (DDP) were studied. Sixteen healthy adult guinea pigs were used for the experiment. A standard dosage DDP (1.5 mg/kg/d) was administered over a period of 5–20 days. A clear degeneration pattern was found (ranging from no changes to cystic degeneration with protrusion of marginal cells followed by loss of marginal cells). DDP seems to be especially toxic for marginal cells in stria vascularis in the guinea pig.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00454261
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