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  • 1
    Digitale Medien
    Digitale Medien
    Uronic Acid-Containing Glycosaminoglycans and Keratan Sulfate Are Present in the Tectorial Membrane of the Inner Ear: Functional Implications
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 307 (1993), S. 391-396 
    Details
    ISSN: 0003-9861
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1006/abbi.1993.1605
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  • 2
    Digitale Medien
    Digitale Medien
    Adenine nucleotides of the stria vascularis (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 224 (1979), S. 89-95 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Adenylate energy charge ; Energy status ; Phosphorylation state ; Inner ear perfusion ; Artificial blood ; Fluorocarbons ; Endolymphatic potential
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The levels of the adenine nucleotides ATP, ADP, and AMP in the stria vascularis were measured under normal conditions, and following various durations of ischemia. The concentrations of these compounds were used for the calculation of the adenylate energy charge, the energy status and the phosphorylation state of the stria. Following 10 min of ischemia the adenylate energy charge had decreased three fold, the energy status seven fold and the phosphorylation state 14 fold. To study the potential for recovery of strial function following various brief and prolonged ischemic intervals, a method for the perfusion of the ear via the anterior inferior cerebellar artery was developed. For various reasons it was found advantageous to use “artificial blood” as perfusate, relying upon fluorocarbons as oxygen carriers. The endolymphatic potential was used as electrical indicator of strial function. Recovery of the endolymphatic potential following brief periods of ischemia was paralleled by a corresponding increase of the ATP levels and a drastic decrease of the AMP levels of the stria vascularis. Preliminary results on the effects of substrate-free perfusion are presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00455229
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  • 3
    Digitale Medien
    Digitale Medien
    Stimulus-induced release of endogenous amino acids from skins containing the lateral-line organ in Xenopus Laevis (1980)
    Springer
    Experimental brain research 40 (1980), S. 97-101 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Afferent transmitter ; Lateral line ; Glutamate ; Aspartate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The release of endogenous amino acids from skins of Xenopus laevis was studied by comparing the effects of pulsatile water motion on the efflux of glutamate and aspartate from isolated skins with and without lateral-line stitches. The stimulated efflux of glutamate from stitch skins was significantly greater than its stimulated efflux from non-stitch skins (p〈0.01). The results for aspartate were less clear cut. Although the source and mechanisms underlying the greater stimulated efflux from stitch skins remain to be determined, the results demonstrate that differences can be detected between stitch and non-stitch skins under stimulus conditions which should induce release of the afferent transmitter substance(s).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00236667
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  • 4
    Digitale Medien
    Digitale Medien
    Reevaluation of adenylate cyclase in Reissner's membrane (1978)
    Springer
    European archives of oto-rhino-laryngology and head & neck 221 (1978), S. 311-312 
    Details
    ISSN: 1434-4726
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00491468
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  • 5
    Digitale Medien
    Digitale Medien
    Partial amino acid sequence of organ of Corti protein OCP-II (1990)
    Springer
    European archives of oto-rhino-laryngology and head & neck 248 (1990), S. 15-18 
    Details
    ISSN: 1434-4726
    Schlagwort(e): OCP-II ; Organ of Corti ; Proteins ; Amino acid sequence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We have previously described two low-molecular-weight, highly acidic proteins which are present in the organ of Corti in extremely high concentrations. Since the function of these proteins is not known, they have been assigned the tentative names OCP-I and OCP-II. In the hope of obtaining information about their function through homology studies, we have initiated amino acid sequencing of these proteins. We have recently succeeded in obtaining a brief amino-terminal sequence of OCP-II. We now report on a significant extension of the amino-terminal sequence of OCP-II and our first results on sequences of peptide fragments obtained by limited digestion with V8 protease. Together, the sequenced segments account for about one-third of the total sequence. Comparisons with the sequences of known proteins suggest that OCP-II is not a structural protein, but that it may exhibit biologic activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00634774
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  • 6
    Digitale Medien
    Digitale Medien
    Organ of Corti-specific polypeptides: OCP-I and OCP-II (1980)
    Springer
    European archives of oto-rhino-laryngology and head & neck 226 (1980), S. 123-128 
    Details
    ISSN: 1434-4726
    Schlagwort(e): Organ of Corti ; Organ-specific polypeptides ; Two-dimensional polyacrylamide gel electrophoresis ; Guinea pig ; Rat ; Actin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Two polypeptides, OCP-I and OCP-II, specific to the organ of Corti of the guinea pig and the rat, were detected by two-dimensional polyacrylamide gel electrophoresis. They were neither present in other inner ear structures, nor in other organs tested. The two polypeptides constitute a substantial portion of the total protein of the organ of Corti. Both inner and outer layer of the organ of Corti contained approximately equal amounts of OCP-I and OCP-II. The molecular weights of OCP-I and OCP-II are 37,000 and 22,500 daltons, respectively. The corresponding pI values are 4.9 and 5.1, respectively. In addition, actin and tubulin were detected in both layers of the organ of Corti.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00455126
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