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  • 1
    Digitale Medien
    Digitale Medien
    A Review and Predictive Models of Gang ioside Uptake by Biological Membranes (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 61 (1993), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1993.tb02140.x
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of Cell Density on Lipids of Human Glioma and Fetal Neural Cells (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 36 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Gangliosides, phospholipids, and cholesterol of human glioma (12-18) and fetal neural cells (CH) were analyzed at specified cell densities, from sparse to confluent. Total ganglioside sialic acid, phospholipid phosphorus, and cholesterol increased in the glioma cells on a per cell, mg protein, or mg total lipid basis two- to threefold as cell density increased 25-fold. These same three constituents in the fetal cells increased with cell density on a per cell and mg protein basis but not on a per mg total lipid basis. In glioma cells, the di- and trisialogangliosides (GD2+ GDlb+ GT1) increased from 1–2% of total ganglioside sialic acid at sparse densities to 7–8% at intermediate (logarithmic phase) densities to 10–13% at confluent densities. The set of simpler gangliosides (GM4+ GM3+ GM2) decreased from 50% of total ganglioside sialic acid at sparse glioma cell densities, to 36% at intermediate and 30% at confluent densities. In the fetal neural cells, the set of gangliosides (GM4+ GM3+ GM2) had about 48% of total ganglioside sialic acid in both sparse and confluent preparations. The fetal cells were twofold higher in GM3 (32.4 ± 2.1%) than the glioma cells (16.8 ± 1.6%), but lower in GMt (9.1 ± 0.9% versus 18.2 ± 1.8%), cell densities notwithstanding. Confluent cell preparations of both cell lines were consistently higher in ethanolamine plasmalogen than sparse cells. We conclude that in these two neural cell lines quantitative changes in ganglioside and phospholipid species occurred correlatively as cell densities increased. Higher glioma cell densities were associated with greater proportions of complex ganglioside species. These changes in cell membrane constituents during growth may result from cell contact and may indicate a role for them in cell growth regulation and/or differentiation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb10821.x
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  • 3
    Digitale Medien
    Digitale Medien
    Ganglioside composition of peripheral nerve undergoing Wallerian degeneration (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10514.x
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  • 4
    Digitale Medien
    Digitale Medien
    CHANGES IN THE SCIATIC NERVE OF THE RABBIT AND ITS TISSUE CONSTITUENTS DURING DEVELOPMENT (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— A segment, defined by gross anatomic boundaries, which comprises most of the sciatic nerve was dissected from rabbits aged from birth to 1 yr. The mean and standard deviation of the variance determined for the weights of pairs of nerve units removed from single animals of an age group did not exceed 2·7 per cent and 12·3 per cent respectively of the average weight of the two nerve units which were the values determined for a group of newborn animals. During the period from birth to one year of age, the weight and length of the nerve unit increased 47- and 6-fold respectively while the animal's weight increased 78-fold. Whereas the nerve unit length increased little after 8 weeks, its weight and that of the whole animal continued to increase up to 1 year. Estimations of nucleic acids in the nerve unit from adult animals gave values of 54 μg DNA-P and 25 μg RNA-P per g fresh weight. During the period birth to 1 yr the absolute amount of DNA in the nerve unit increased 11-fold, 71 per cent of this having occurred by 6 weeks of age. The absolute amount of RNA increased 11 -fold by 8 weeks of age and remained constant thereafter. During the period birth to 1 yr, the proportion of the nerve constituents accounted for by lipid-free solids remained constant at 10 per cent, while lipids increased from 5 to 18 per cent and tissue water declined from 84 to 71 per cent. Changes in some lipid classes were examined also. Increases of absolute content in the nerve unit over the first year and concentrations on a fresh weight basis attained in year-old animals were as follows: cholesterol, 132-fold and 86 mg/g; triglyceride 554-fold and 43·2 mg/g; total phospholipid, 85-fold and 61 mg/g; cerebroside 205-fold and 28 μmol/g; sulphatide, 154-fold and 10 μmol/g; monogalactosyl diglyceride, 31-fold and 0·6 μmol/g. The ratio cholesterol/phospholipid/galactolipid in whole nerve units from adult animals was 2·0/2·1/1·0 and the change in this ratio in the first year was compatible with enrichment of myelin in galactolipid during myelination. The ratio of cerebroside to sulphatide increased from 2·0 to 2·6 during this period. Increases in absolute content and concentrations attained for sialic acid-containing components representing cell surface constituents were as follows: ganglioside sialic acid, 33-fold, and 83 μg/g; glycoprotein sialic acid, 57-fold and 371 μg/g. The quantitative pattern of ganglioside fractions separated by thin-layer chromatography in one direction resembled that of whole brain and was the same at all ages studied. The changes reported reflect a composite picture of changes in a variety of cell membranes indicative of marked variation during development in quantity and composition of membranes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb10751.x
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  • 5
    Digitale Medien
    Digitale Medien
    Psychological Deficit (1966)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Psychology 17 (1966), S. 111-144 
    Details
    ISSN: 0066-4308
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Psychologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.ps.17.020166.000551
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  • 6
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    Unbekannt
    The repetition of single speech sounds under delayed auditory feedback (1971)
    London, etc. : Periodicals Archive Online (PAO)
    British journal of psychology. 62 (1971) 73 
    Details
    ISSN: 0007-1269
    Thema: Psychologie
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0047-1971-062-00-000010
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  • 7
    Digitale Medien
    Digitale Medien
    Apocrine carcinoma and apocrine metaplasia (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02030.x
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  • 8
    Digitale Medien
    Digitale Medien
    Prediction of Fracture Risk by Radiographic Absorptiometry and Quantitative Ultrasound: A Prospective Study (1998)
    Springer
    Calcified tissue international 63 (1998), S. 380-384 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Key words: Fracture risk — Radiographic absorptiometry — Quantitative ultrasound — Prospective study.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Abstract. Recent developments in computer-assisted radiographic absorptiometry (RA) and quantitative ultrasound techniques (QUS) provide readily accessible and relatively inexpensive methods for assessing bone mineral status. However, few population-based studies have investigated the ability of RA and ultrasound to predict fracture risk prospectively. We explored the ability of RA and QUS to predict fracture risk among 560 postmenopausal women from the Hawaii Osteoporosis Study; average follow-up was 2.7 years. An incident vertebral fracture was defined as a decrease of more than 15% in vertebral heights on subsequent films. Self-reported nonspine fractures were verified by medical records. The prospective associations of vertebral fractures, nonspine fractures, and any (spine or nonspine) fractures with bone measurements were examined using logistic regression, adjusting for age. Both phalangeal bone mineral density (BMD) and metacarpal BMD, measured using RA, predicted future fracture risk. The age-adjusted odds ratios (corresponding to 1 SD decrease in BMD) for vertebral fractures, nonspine fractures, and any fractures were 3.41, 1.50, and 1.91, respectively, for phalangeal BMD, and 1.71, 1.49, 1.55, respectively for metacarpal BMD. Calcaneal broadband ultrasound attenuation (BUA) also showed significant association with fracture risk, with age-adjusted odds ratios of 1.50, 1.89, and 1.72 for vertebral fractures, nonspine fractures, and any fractures, respectively. We conclude that hand RA and calcaneal BUA are significant predictors of nonspine fracture, vertebral fracture, and overall fracture risk. The attractive features of these techniques, such as portability, relatively low cost, and ease of use, make them promising alternatives to conventional bone measurement techniques used for the assessment of fracture risk.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002239900544
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  • 9
    Digitale Medien
    Digitale Medien
    Treatment of postmenopausal osteoporosis with continuous daily oral alendronate in comparison with either placebo or intranasal salmon calcitonin (1993)
    Springer
    Osteoporosis international 3 (1993), S. 21-27 
    Details
    ISSN: 1433-2965
    Schlagwort(e): Osteoporosis ; Bisphosphonates ; Alendronate ; Calcitonin ; Postmeno pausal
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Alendronate sodium (ALN) is a potent amino bisphosphonate which specifically inhibits osteoclastic bone resorption and has been found to reverse bone loss in several animal models. To determine if daily oral ALN treatment could prevent or reverse bone loss in osteoporotic postmenopausal women, and to compare ALN to intranasal salmon calcitonin (CT), a 2-year, double-masked, randomized, placebo-controlled study was initiated at 9 clinical centers in Italy. Two hundred and eighty six postmenopausal women (age 48–76) with spinal bone mineral density (BMD) ≥2 SD below adult mean peak, with or without vertebral crush fractures, were randomized to one of four treatment arms: ALN 10 mg daily, ALN 20 mg daily or matching placebo (these groups all double-masked), or CT 100 IU daily (open label) for 2 years. All patients received supplemental calcium (as carbonate) 500 mg daily. Bone mass was measured by dual-energy X-ray absorptiometry of the PA lumbar spine (LS) and proximal femur (femoral neck and trochanter) at 6-month intervals. Subject safety was measured through sequential clinical and laboratory evaluation. A planned 1-year interim analysis of this ongoing study was performed cetrally in a manner that maintains the double-mask for all subjects receiving oral study drug. Relative to PBO, ALN at either 10 mg or 20 mg daily increased LS BMD by 4.7% and 6.1%, respectively; each increased femoral neck BMD by 3.1% and increased trochanter BMD by 3.3% and 3.8% respectively. In contrast, CT failed to significantly increase BMD of either the spine, femoral neck or trochanter, either relative to baseline or to PBO. ALN decreased biochemical markers or bone turnover, whereas both PBO and CT were ineffective. No serious adverse experiences attributable to the use of alendronate were detected. In summary, daily oral ALN for one year appears to be effective in decreasing bone turnover and increasing bone mass at the spine and the hip. In contrast, daily CT 100 IU had no significant effects either to reduce bone turnover or to increase bone mass at either site. In conclusion, ALN effectively increased bone mass in osteoporotic menopausal women, and was associated with an excellent safety profile.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01623004
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  • 10
    Digitale Medien
    Digitale Medien
    Multinational, Placebo-Controlled, Randomized Trial of the Effects of Alendronate on Bone Density and Fracture Risk in Postmenopausal Women with Low Bone Mass: Results of the FOSIT Study (1999)
    Springer
    Osteoporosis international 9 (1999), S. 461-468 
    Details
    ISSN: 1433-2965
    Schlagwort(e): Key words:Alendronate – bisphosphonate – Bone mineral density – Fractures – Postmenopausal osteoporosisRID=""ID="" 〈E5〉Correspondence and offprint requests to:〈/E5〉 Huibert A. P. Pols, MD, PhD, Department of Internal Medicine III, Erasmus University Medical School, PO Box 1738, 3000 DR Rotterdam, The Netherlands. Tel: +31 10 4635956. Fax: +31 10 4633268. e-mail: pols@epib.fgg.eur.nl.RID=""ID=""Fosamax〈SUP〉®〈/SUP〉 is a registered trademark of Merck & Co., Inc., Whitehouse Station, NJ, USA.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract: This randomized, double-masked, placebo-controlled trial evaluated the safety, tolerability and effects on bone mineral density (BMD) of alendronate in a large, multinational population of postmenopausal women with low bone mass. At 153 centers in 34 countries, 1908 otherwise healthy, postmenopausal women with lumbar spine BMD 2 standard deviations or more below the premenopausal adult mean were randomly assigned to receive oral alendronate 10 mg (n = 950) or placebo (n = 958) once daily for 1 year. All patients received 500 mg elemental calcium daily. Baseline characteristics of patients in the two treatment groups were similar. At 12 months, mean increases in BMD were significantly (p≤0.001) greater in the alendronate than the placebo group by 4.9% (95% confidence interval 4.6% to 5.2%) at the lumbar spine, 2.4% (2.0% to 2.8%) at the femoral neck, 3.6% (3.2% to 4.1%) at the trochanter and 3.0% (2.6% to 3.4%) for the total hip. The incidence of nonvertebral fractures was significantly lower in the alendronate than the placebo group (19 vs 37 patients with fractures), representing a 47% risk reduction for nonvertebral fracture for alendronate-treated patients (95% confidence interval 10% to 70%; p= 0.021). Incidences of adverse events, including upper gastrointestinal adverse events, were similar in the two groups. Therefore, for postmenopausal women with low bone mass, alendronate is well tolerated and produces significant, progressive increases in BMD at the lumbar spine and hip in addition to significant reduction in the risk of nonvertebral fracture.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00004171
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