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  • 1
    Digitale Medien
    Digitale Medien
    Amphiphilic derivatives of alginate: evidence for intra- and intermolecular hydrophobic associations in aqueous solution (1993)
    s.l. : American Chemical Society
    Langmuir 9 (1993), S. 3334-3337 
    Details
    ISSN: 1520-5827
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/la00036a002
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  • 2
    Digitale Medien
    Digitale Medien
    Intravenous nicardipine in hypertensive children (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 712-714 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Nicardipine ; Children ; Hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Fourteen hypertensive patients hospitalized in a paediatric intensive care unit were studied to evaluate safety and hypotensive efficacy of intravenous nicardipine. Systolic and diastolic blood pressure significantly decreased 1 h after the beginning of the treatment (1 μg/kg per minute). Mean decrease in systolic blood pressure during the first 24 h was between 9.9% and 13.4% of the initial value. Mean lowering of diastolic blood pressure was between 16.7% and 25.6%. Nicardipine did not significantly affect heart rate with dose of 1 μg/kg per minute. No clinical side-effects were observed. Nicardipine could be a first line drug for the treatment of hypertension in paediatric intensive care units.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01953981
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  • 3
    Digitale Medien
    Digitale Medien
    Dietary PUFAs Improve Liver Insulin Receptor Tyrosine Kinase Activity in High Sucrose-Fed Rats (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 683 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb35728.x
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  • 4
    Digitale Medien
    Digitale Medien
    Lipid Modulation of Insulin Receptor Tyrosine Kinase Activity in Cultured Cells, Animals, and Reconstituted Systems (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 683 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb35702.x
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  • 5
    Digitale Medien
    Digitale Medien
    Elicitation of Decision-Makers’Preferences for Management of Major Hazards (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 11 (1991), S. 0 
    Details
    ISSN: 1539-6924
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Energietechnik
    Notizen: A survey has been conducted among decision-makers from the urban area of Lyon (France). It aimed at elicitating attitudes toward industrial risk, with an emphasis on major hazards. The sample was quite small (23 individuals), but most of the actual decision-makers of the area belonged to it. A questionnaire allowed to look at the weights that are given to “catastrophic accidents,” when compared to more usual ones. It showed that decision-makers are strongly “adverse to catastrophes.” The findings support many risk management approaches that are based on assigning an “extra weight” to potential accidents that may cause a high number of casualties.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1539-6924.1991.tb00596.x
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  • 6
    Digitale Medien
    Digitale Medien
    Serious childhood angiomas: unsuccessful alpha-2b interferon treatment. A report of four cases (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Over a 4-year period, we managed four children with alarming haemangiomas (two cases of Kasabach-Merritt syndrome and two life-threatening haemangiomas). Systemic steroid therapy was ineffective. Other treatments (radiotherapy, anti-platelet drugs) were also ineffective in the Kasabach-Merritt patients. On the basis of recent reports on the effects of interferon on endothelial cells, we used alpha-2 interferon therapy, but obtained no response.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb03181.x
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  • 7
    Digitale Medien
    Digitale Medien
    Technetium-99m labelled human serum albumin for ventriculography: a comparative evaluation of six labelling kits (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 465-472 
    Details
    ISSN: 1619-7089
    Schlagwort(e): Technetium-99m labelled human serum albumin ; Labelling kit ; Ventriculography ; Blood pool agent
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In this study we have compared the characteristics of six labelling kits for the preparation of technetium-99m labelled human serum albumin (99mTc-HSA) and evaluated the usefulness of the various 99mTc-HSA preparations as blood pool tracer agents. The amount of the principal ingredients, i.e. HSA and stannous ions, varies largely between the studied kits and this is probably a reason for the observed differences in the labelling rate. Analysis of the reaction mixtures after labelling of the respective kits with 99mTc showed in each preparation the presence of four to five radioactive components in variable relative amounts. The retention time of the main component on size-exclusion high-performance liquid chromatography (SEC-HPLC) was identical for all preparations. Biodistribution of the HPLC-isolated fractions was studied in mice. The components with the shortest and longest retention times on HPLC show poor retention in the plasma. The three intermediate fractions, including the principal peak, are initially retained relatively well in the blood (60%–70% of the injected dose after 10 min), but clearly to a lower degree than iodine-125 labelled HSA. Moreover, they diffuse out of the vascular compartment at a much higher rate than 125I-HSA. The biological behaviour of the main component of the various preparations was clearly different, despite the identical retention time on SEC-HPLC. Study of the total preparations in mice and a rabbit showed that two of them are cleared rapidly from the blood and cannot be considered valuable blood pool tracers. Diffusion of the other preparations out of the blood is slower but also considerable and compromises their use for ventriculography.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00175158
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  • 8
    Digitale Medien
    Digitale Medien
    Technetium-99m mercaptoalbumin as a potential substitute for technetium-99m labelled red blood cells (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 473-482 
    Details
    ISSN: 1619-7089
    Schlagwort(e): 99mTc-labelled human serum albumin ; 99mTc-mercaptoalbumin ; Ventriculography ; 99mTc-labelled erythrocytes ; 99mTc-DMP-HSA
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Technetium-99m labelled red blood cells (99mTc-RBCs) are far superior to 99mTc-labelled human serum albumin (99mTc-HSA) for radionuclide ventriculography, but their labelling is more complex, time consuming and risk bearing (in vitro labelling) or suffers from interference by some medications (in vivo labelling). We have now modified HSA by the introduction of mercapto groups with the purpose of preparing stable and practical 99mTc-mercaptoalbumin with long retention in the vascular system, that could replace 99mTc-RBCs. HSA was incubated with N-succinimidyl S-acetylthioacetate (SATA) or N-succinimidyl 2,3-di(S-acetylthio) propionate (SATP) to introduce a chain containing one or two protected sulfhydryl groups on some of the lysine amino groups. After purification by size-exclusion chromatography (SEC), the mercapto groups were deprotected by incubation at alkaline pH or by treatment with hydroxylamine. The reaction products were used with or without SEC purification for direct or exchange labelling experiments with 99mTc at neutral pH. SEC-HPLC was used to determine labelling yields and to isolate pure 99mTc-mercaptoalbumin. Stable 99mTc-mercaptoalbumin complexes could be formed in 90%–95% yield after coupling albumin with SATA or SATP in all molar ratios used followed by deacetylation in one of the mentioned conditions. The most favourable results were obtained after reaction of SATA or SATP with HSA in a 25: 1 ratio and deprotection with NH2OH. The stability of the resulting 99mTc-mercaptoacetyl-albumin (99mTc-MAHSA) and 99mTc-dimercaptopropionyl-albumin (99mTcDMP-HSA) and their retention in vivo in plasma of mice and rabbits are clearly higher than that of conventional 99mTc-HSA preparations. 99mTc-DMP-HSA approaches the behaviour of 125I-HSA quite well in both animal species. A preliminary study with 99mTc-DMP-HSA in a volunteer showed a retention in the vascular compartment almost identical to that of 99mTc-RBCs and clearly higher than that of a common 99mTc-HSA preparation. The results indicate that these 99mTc-mercaptoalbumins and especially 99mTc-DMP-HSA are very promising as a practical alternative to 99mTc-RBCs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00175159
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  • 9
    Digitale Medien
    Digitale Medien
    When is random random? (1990)
    [s.l.] : Nature Publishing Group
    Nature 344 (1990), S. 823-823 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/344823b0
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  • 10
    Digitale Medien
    Digitale Medien
    Children of choice (1993)
    [s.l.] : Nature Publishing Group
    Nature 364 (1993), S. 10-10 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SIR - According to James Watson1: "The world must shed the idea that this is evil [abortion of fetuses diagnosed with genetic defects], as it is a true act of moral cowardice to allow children to be born with known genetic defects." The idea is an old one. In ancient Sparta, Olympic athletes were ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/364010b0
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