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  • 1
    Electronic Resource
    Electronic Resource
    Vein of Galen vascular malformations in infants: clinical, radiological and therapeutic aspect (1997)
    Springer
    European radiology 7 (1997), S. 1252-1258 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Vein of Galen ; Embolization ; Vascular malformation ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A series of 14 vein of Galen vascular malformations diagnosed in the pediatric populations and treated at the Hospital for Sick Children-Necker, Paris, between 1988 and 1994 is presented. Five of the patients were diagnosed in the neonatal period, of whom 4 presented with life-threatening, intractable cardiac decompensation and high-flow arteriovenous fistulae. Embolization was performed on vital indications in 4 patients during the first week after birth. One embolization failed with fatal outcome. Of the 3 who were embolized, 2 succumbed within 1 week and 1 survived with marked improvement of cardiac symptoms. The older children presented with hydrocephalus and neurologic symptoms. The 10 patients older than 1 year were embolized. These procedures were successful in 90 %, with hemodynamic stabilization and improvement of clinical symptoms. In this group the mortality rate was 10 %. The total mortality rate was 29 %. Hydrocephalus was secondary to a compression of the Sylvian aqueduct in 44 % of cases. Five patients had ventricular drainage before embolization followed by a staged elective embolization. Transarterial embolizations were performed in 11 patients, whereas 2 patients were embolized via the transvenous route.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050285
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term treatment of persistent hyperinsulinaemic hypoglycaemia of infancy with diazoxide: a retrospective review of 77 cases and analysis of efficacy-predicting criteria (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 628-633 
    Details
    ISSN: 1432-1076
    Keywords: Key words Hyperinsulinism ; Hypoglycaemia ; Diazoxide ; Sulphonylureas ; Management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Primary persistent hyperinsulinaemic hypoglycaemia of infancy is rare. Diazoxide treatment remains the mainstay of medical therapy in long-term management. We reviewed 77 cases of primary persistent hyperinsulinism in neonates and infants who were treated with diazoxide and studied criteria predictive of therapeutic efficacy. The only criterion identified was age at manifestation. All but 1 of the 31 neonatal cases were unresponsive to diazoxide. Responsiveness increased with age: 12 of 39 early-infantile cases, and all seven late-infantile cases were diazoxide-responsive. In responders, a diazoxide dose of 10–15 mg/kg per day was always effective, suggesting an “all or none” response. Diazoxide-resistant hyperinsulinism is characterized by its severity with higher plasma insulin levels. The analysis of 46 surgically treated patients showed that the efficacy of diazoxide is not related to the aetiology of the pancreatic lesions. In six cases, after many years of management, diazoxide treatment was stopped without recurrence of hypoglycaemia. Conclusion Diazoxide is an efficient treatment in the long-term management of most persistent hyperinsulinaemic hypoglycaemia of infancy revealed in infants and children but is usually ineffective in neonatal forms. Drug efficacy does not correlate with anatomical lesions. Medical treatment can sometimes be stopped after many years of management without recurrence of disease manifestations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050900
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  • 3
    Electronic Resource
    Electronic Resource
    Intussusception in infants and children: feasibility of ambulatory management (1999)
    Springer
    European journal of pediatrics 158 (1999), S. 707-710 
    Details
    ISSN: 1432-1076
    Keywords: Key words Intussusception ; Child ; Barium enema ; Ambulatory management ; Cost-effectiveness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the ambulatory management of ileo-colic intussusception in infants and children, a retrospective study over 3 years of 113 children treated for ileo-colic intussusception in a paediatric emergency department was undertaken with the aim of shortening the length of stay. A total of 113 children aged 10 days to 9 years (median 12 months) were treated for intussusception between January 1993 and December 1996. None had septic shock or peritoneal aeric effusion. Barium enema reduction was attempted in all patients. Successful reduction rate was 81%. Fifty patients (44.2%) were completely ambulatory managed and 42 were hospital-supervised after successful enema reduction. Twenty-one children underwent laparotomy after failure of enema. With the ambulatory device, costs were reduced ($1000/case) compared with conventional in-patient treatment. Conclusion Outpatient treatment of acute ileo-colic intussusception is secure and reduces costs. It depends on the willingness of the medical team but requires simultaneous adaptation of hospital funding to promote this trend.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310051184
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  • 4
    Electronic Resource
    Electronic Resource
    Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia (2001)
    Oxford, UK : Blackwell Science Ltd
    BJOG 108 (2001), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To study the potential for prenatal magnetic resonance imaging to predict pulmonary hypoplasia in congenital diaphragmatic hernia.Design Prospective observational study.Setting Tertiary care centre.Participants Thirteen cases of congenital diaphragmatic hernia (11 left, 2 right) without associated anomalies and 74 controls.Methods Measurements by magnetic resonance imaging of fetal lung volume were achieved. In the control fetuses, a regression analysis was performed to associate fetal lung volume with gestational age. This yielded a formula allowing calculation of the expected fetal lung volume as a function of gestational age. In the cases with congenital diaphragmatic hernia, the observed/expected fetal lung volume ratio was compared with perinatal outcome.Main outcome measures Neonatal mortality and pulmonary hypoplasia, which was defined as lung/body weight ratios less than 0.012.Results The expected fetal lung volume was derived from the following formula: Fetal lung volume (mL) = exp (1.24722 + 0.08939 × gestational age in weeks). The observed/expected fetal lung volume ratio was significantly lower in congenital diaphragmatic hernia (median: 0.31, range: 0.06–0.63), than in controls (median: 0.99, range: 0.42–1.94). This ratio was significantly less in the infants with congenital diaphragmatic hernia who died (median: 0.26, range: 0.06–0.63) compared with those who survived (median: 0.46, range: 0.35–0.56). The observed: expected fetal lung volume ratio was significantly correlated with the post mortem lung: body weight ratio.Conclusion In isolated congenital diaphragmatic hernia, fetal lung volume measurement by magnetic resonance imaging is a potential predictor of pulmonary hypoplasia and postnatal outcome. Further studies are required to establish the clinical value of magnetic resonance imaging for the prenatal assessment of fetal lungs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.2001.00184.x
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  • 5
    Electronic Resource
    Electronic Resource
    Serious childhood angiomas: unsuccessful alpha-2b interferon treatment. A report of four cases (1993)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 129 (1993), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Over a 4-year period, we managed four children with alarming haemangiomas (two cases of Kasabach-Merritt syndrome and two life-threatening haemangiomas). Systemic steroid therapy was ineffective. Other treatments (radiotherapy, anti-platelet drugs) were also ineffective in the Kasabach-Merritt patients. On the basis of recent reports on the effects of interferon on endothelial cells, we used alpha-2 interferon therapy, but obtained no response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1993.tb03181.x
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  • 6
    Electronic Resource
    Electronic Resource
    Non-operative removal of an unusual foreign body from the duodenum after duodeno-jejunostomy (1979)
    Springer
    Pediatric radiology 8 (1979), S. 51-53 
    Details
    ISSN: 1432-1998
    Keywords: Duodenum ; Foreign body removal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The authors report a case of peroral removal of an intraduodenal foreign body in a 6 week old infant. The coaxial technique employed facilitates catheter manipulation and avoids traumatic lesions arising from manoeuvres during removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00973680
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  • 7
    Electronic Resource
    Electronic Resource
    Intracranial venous anomalies associated with atretic cephalocoeles (2000)
    Springer
    Pediatric radiology 30 (2000), S. 743-747 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Midline scalp lesions are frequent in children. They include soft-tissue masses and atretic meningocoeles. Their recognition is important as their treatment differs. Intracranial venous anomalies are known to be associated with atretic cephalocoeles.¶Materials and methods. A retrospective study was undertaken to assess the frequency of intracranial venous anomalies associated with atretic meningocoeles (AT). Thirty-one patients with AT were studied by MRI. There were 13 meningocoeles and 14 encephalocoeles; 4 have not yet received surgery.¶Results. Venous anomalies were found when the cephalocoeles lay above the torcular. They include absence of the straight sinus and duplication of the longitudinal sinus.¶Conclusion. Venous anomalies are frequent in atretic cephalocoeles and are part of the dysraphic state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002470000328
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  • 8
    Electronic Resource
    Electronic Resource
    Role of embolisation in the treatment of bronchopulmonary sequestration (2000)
    Springer
    Pediatric radiology 30 (2000), S. 769-773 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Sequestrations represent bronchopulmonary malformations that are increasingly diagnosed antenatally. After birth, the therapeutic approach in asymptomatic children is debated, as some may spontaneously regress.¶Objective. To evaluate the efficacy of embolisation of the feeding systemic artery in the treatment of bronchopulmonary sequestration.¶Materials and methods. Sixteen children with bronchopulmonary sequestration were treated by endovascular embolisation of the feeding systemic artery.¶Results. Ten patients were considered cured by embolisation alone. One patient was operated on after unsuccessful embolisation, three had partial regression of the lung mass and two are still under follow-up.¶Conclusions. Our experience indicates that bronchopulmonary sequestrations in children can be treated by embolisation alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002470000332
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  • 9
    Electronic Resource
    Electronic Resource
    CT scan patterns of pulmonary alveolar proteinosis in children (1999)
    Springer
    Pediatric radiology 29 (1999), S. 147-152 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. To study computed tomographic (CT) findings in children with pulmonary alveolar proteinosis (PAP) more extensively. Objective. To describe the CT features at the time of diagnosis and after therapeutic broncho-alveolar lavage (BAL). Materials and methods. We retrospectively reviewed the CT scans of five children (aged 3 months to 4 years) examined because of incidental bronchitis (n = 1), disease in a sibling (n = 1) and relapsing fever, cough and dyspnoea (n = 3). Each patient had an initial CT scan. Two asymptomatic cases were not treated but were followed up by plain chest films. The other three had BAL and follow-up CT. Results. Initial CT in all cases showed a diffuse reticulomicronodular pattern associated in three cases with posterior bilateral alveolar infiltrates. CT in the two asymptomatic patients remained unchanged or slightly improved without BAL. After BAL, a variable decrease of lung infiltrates was observed. Conclusions. Correlation between the extent of alveolar consolidation and severity of disease was found. Anatomical and pathological considerations allow us to consider that the classical reticulomicronodular pattern is not due to an interstitial infiltration but to alveoli filled with the abnormal material characteristic of PAP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002470050560
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  • 10
    Electronic Resource
    Electronic Resource
    Embolisation of vascular lesions of the spinal column in childhood: a report of three cases (1996)
    Springer
    Neuroradiology 38 (1996), S. 809-811 
    Details
    ISSN: 1432-1920
    Keywords: Key words Children ; Embolisation ; Spinal column angioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report three cases of embolisation of hypervascular vertebral lesions in children. We embolised two cases of osteoblastoma prior to surgery, and one thoracic vertebral haemangioma. The technique and clinical results are described. We conclude that embolisation of vascular lesions of the spinal column in children is useful preoperatively or to reduce pain in vertebral haemangiomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050354
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