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  • Engineering  (2)
  • Amino acids  (1)
  • 1
    ISSN: 1438-2199
    Schlagwort(e): Amino acids ; N-Acetylcysteine ; Cysteine ; Glutathione ; Diethyl maleate ; Perfused rat liver
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Effect ofN-acetyl-l-cysteine (NAC) administration on cysteine and glutathione (GSH) contents in rat liver and kidney was studied using intact and diethyl maleate (DEM)-treated rats and perfused rat liver. Cysteine contents increased rapidly, reaching peak at 10 min after intraperitoneal NAC administration. In liver mitochondria it increased slowly, reaching peak at 60 min. GSH content did not change significantly in these tissues. However, in liver and kidney depleted of GSH with DEM, NAC administration restored GSH contents in 60 and 120 min, respectively. Perfusion with 10 mM NAC resulted in 76% increase in liver cysteine content, but not in GSH content. Liver perfusion of DEM-injected rats with 10 mM NAC restored GSH content by 15%. Present findings indicate that NAC is an effective precursor of cysteine in the intact liver and kidney and in the perfused rat liver, and that NAC stimulated GSH synthesis in GSH-depleted tissues.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 23 (1996), S. 397-411 
    ISSN: 0271-2091
    Schlagwort(e): GMRES ; mild slope equation ; iterative solvers ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: The mild slope equation in its linear and non-linear forms is used for the modelling of nearshore wave propagation. The finite difference method is used to descretize the governing elliptic equations and the resulting system of equations is solved using GMRES-based iterative method. The original GMRES solution technique of Saad and Schultz is not directly applicable to the present case owing to the complex coefficient matrix. The simpler GMRES algorithm of Walker and Zhou is used as the core solver, making the upper Hessenberg factorization unneccessary when solving the least squares problem. Several preconditioning-based acceleration strategies are tested and the results show that the GMRES-based iteration scheme performs very well and leads to monotonic convergence for all the test-cases considered.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 28 (1998), S. 1053-1071 
    ISSN: 0271-2091
    Schlagwort(e): turbulence modeling ; internal flow ; flow separation ; shock-boundary layer interaction ; finite volume method ; Engineering ; Numerical Methods and Modeling
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: The existence of shock-turbulent boundary layer interactions lead to very complicated flow phenomena and pose a challenge for numerical simulation. In this paper, two turbulence models, the Baldwin-Lomax (B-L) model and the Johnson-King (J-K) model, which were originally developed for simple external flow simulation, are modified to model complex high-speed internal separated flows. The full Navier-Stokes solver used in this paper is based on a cell-centered finite volume method and multistepping time marching scheme. Both implicit residual smoothing and local time stepping techniques are incorporated to accelerate the convergence rate. To ensure the numerical stability with the present explicit scheme, a point-implicit treatment to the source term in the ordinary differential equation (ODE) of the J-K model has been developed and has proved to be very effective in modeling such a complex flow. An arc-bump channel flow case has been studied. Comparisons of computed results with experimental data show that the present solver, with the modified turbulence models, predicts the shock and the flow separation very well. The J-K model is found to predict the size of the separation bubble with a higher accuracy. © 1998 John Wiley & Sons, Ltd.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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