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Digitale Medien

Mutation of p53 with loss of heterozygosity in the osteosarcomatous component of a dedifferentiated chondrosarcoma (2000)

Grote, H. J. ; Schneider-Stock, Regine ; Neumann, W. ; [weitere]

Springer

Virchows Archiv 436 (2000), S. 494-497

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ISSN: 1432-2307

Schlagwort(e): Key words Dedifferentiated chondrosarcoma ; p53 mutation ; p53 LOH

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract We investigated a dedifferentiated chondrosarcoma of a 61-year-old woman with an osteosarcomatous high-grade component for p53 alteration. The low-grade cartilaginous and the high-grade osteosarcomatous components of the tumor were macrodissected and evaluated separately by immunohistochemistry and molecular biology. We used PCR-SSCP analysis and direct sequencing to screen exons 4–8 for p53 mutations. The p53 intron 1-polymorphism was investigated for loss of heterozygosity. A functionally relevant p53 missense mutation in codon 193 of exon 6 (A-to-T transversion) with loss of wild-type allele was detected only in the dedifferentiated component. Using the monoclonal antibody DO-1, immunohistochemistry failed to show p53 overexpression. This evidence of p53 mutation may be regarded as at least a co-factor that ”switched” the preexisting low-grade conventional chondrosarcoma to a highly malignant dedifferentiated tumor.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004280050478

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Digitale Medien

The Preparation of Carbodiimides from IsocyantesDedicated to Prof. Dr. Otto Bayer on the occasion of his 60th birthday. (1962)

Neumann, W. ; Fisher, Peter

Weinheim : Wiley-Blackwell

Angewandte Chemie International Edition in English 1 (1962), S. 621-625

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ISSN: 0570-0833

Schlagwort(e): Carbodiimides ; Isocyanates ; Chemistry ; General Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Carbodiimides are formed with simultaneous evolution of CO2 by the reaction of basic catalyst with sterically hindered isocynates. Another generally applicable synthesis of carbodiimides involves intermediate formation of cyclic adducts of isocyanates and carbodiimides, which, upon cleavage, exchange the isocyanate and carbodiimide functions. Both processes are suitable for the preparation of polycarboiimides. Several commercial applications of mono- and polycarbodiimides are pointed out.

Zusätzliches Material: 4 Tab.