ZIB

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Sortierung

Digitale Medien

The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeastSchizosaccharomyces pombe (1996)

Hegde, V. ; McFarlane, R. J. ; Taylor, E. M. ; [weitere]

Springer

Molecular genetics and genomics 251 (1996), S. 483-492

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1617-4623

Schlagwort(e): 5-Azacytidine ; Fission yeast ; DNA repair

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract We have recently demonstrated thatSchizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02172377

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 1 | 1 Treffer