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  • 1990-1994  (2)
  • 1955-1959
  • Gas chromatography  (1)
  • Inorganic ions  (1)
  • 1
    ISSN: 1432-1246
    Schlagwort(e): Acrylonitrile ; Adducts ; Biological monitoring ; Gas chromatography ; Hemoglobin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A new, simple and fast procedure of measuring acrylonitrile (ACN) in ACN derived mercapturic acids such as S-(2-cyanoethyl)-L-cysteine(CyEC), and in hemoglobin (Hb) and plasma protein adducts and urinary metabolites in rats and humans exposed to ACN was developed. ACN in mercapturic acids or proteins was analyzed by capillary gas chromatography (GC) by liberating ACN at a high-temperature in the injector port of GC with or without oxidizing sulfur atoms of the ACN-bound cysteines into sulfoxide form by hydrogen peroxide in vitro. At 350 °C, more than 90% of ACN in authentic CyEC was recovered by this method. Increasing a single ip dose of ACN from 5 to 50 mg/kg produced proportional increases in ACN bound to Hb 24 hr after the treatment. The alkylation of plasma protein with ACN was about 1/10 as low as that of Hb. After repeated daily ip doses of 1–10 mg/kg, ACN in Hb decreased with a half-life of about 9 days. ACN was also detected in the blood of workers exposed to ACN for 1 to 10 years at a Siberian synthetic rubber factory.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1612-1112
    Schlagwort(e): Thin-layer chromatography ; Diethyl-(2-hydroxy-propyl)aminoethyl (QAE)-cellulose ; Hydrochloric acid and chloride media ; Inorganic ions ; Re(VII)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Thin-layer chromatographic behavior of 49 inorganic ions has been systematically studied on diethyl-(2-hydroxy-propyl)aminoethyl (QAE)-cellulose, a strongly basic anion exchanger, in aqueous hydrochloric acid and in acid-ammonium chloride media (0.01 to 1.0 mol dm−3). Aspects of the adsorption behavior of the ions on the cellulose are compared with those on other anion exchangers in the same eluent system. Feasibilities of separation of multicomponent mixtures are proposed on QAE-cellulose in both media. In particular, the selective separation of Re(VII) from many other ions can be accomplished on these systems.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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