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Digitale Medien

Mechanism of postcoital contraception with a combination of steroids and the central M-cholinolytic benactyzine (1975)

Poskalenko, A. N. ; Makusheva, V. P. ; Nikitin, A. I.

Springer

Bulletin of experimental biology and medicine 80 (1975), S. 1221-1223

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ISSN: 1573-8221

Schlagwort(e): postcoital contraception ; tubal transport ; estrogens ; progestins ; benactyzine

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract Blocking central muscarinic (M-) cholinergic systems with benactyzine facilitates the manifestation of the contraceptive effect of estrogen norsteroids in early pregnancy in rats. This effect is connected with lowering of the gonadotropin level and a change in the ratio between follicle-stimulating and luteinizing hormones, interfering with implantation of the fertilized ovum in the endometrium. The rate of transport of the ovum along the fallopian tube and development of the decidual reaction are also changed. The change in rate of movement of the ovum is not accompanied by any disturbance of fertilization. The substances tested showed no cytotoxic action. The use of mestranol and ethinylestradiol in conjunction with norethinodrel and benactyzine may prove promising as a method of short-term contraception in the postcoital period.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00833167

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Digitale Medien

Fertilization and cleavage of the human ovumin vitro (1976)

Nikitin, A. I. ; Nikolaichuk, M. P. ; Kitaev, É. M.

Springer

Bulletin of experimental biology and medicine 81 (1976), S. 451-453

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ISSN: 1573-8221

Schlagwort(e): human ovum ; fertilization and development in vitro

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract A method of cultivating and fertilizing human ova obtained from ovaries removed at operation is described. A special method of sampling active spermatozoa was used for fertilization. Zygote formation was observed 24–36 h after fertilization of the ripe ova, an embryo of the two-cell stage was formed after 36–40 h, and an embryo at the four-cell stage after 48 h. The number of blastomeres reached 8 after 60–64 h, and after approximately 100–120 h the embryos reached the morula stage. The results provide wide scope for the study of the physiology and pathology of early human embryonic development.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00804947

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