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  • 1
    Digitale Medien
    Digitale Medien
    Atomic Force Microscopy Studies of Solid Lipid Nanoparticles (1996)
    Springer
    Pharmaceutical research 13 (1996), S. 1411-1416 
    Details
    ISSN: 1573-904X
    Schlagwort(e): atomic force microscopy ; solid lipid nanoparticles ; controlled drug delivery ; prednisolone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Purpose. Solid Lipid Nanoparticles (SLN) are an alternative carrier system for the controlled delivery of drugs. In most cases prednisolone loaded SLN show a biphasic release behaviour. The initial phase is characterised by a fast drug release, which is followed by a sustained drug release over several weeks. Methods. The particles are produced by high pressure homogenisation of a lipid (e.g. compritol, cholesterol) dispersed in an aqueous surfactant solution. In this study atomic force microscopy was used to image the original unaltered shape and surface properties of the particles. The crystallinity of the nanoparticles was investigated by differential scanning calorimetry. Results. The AFM investigations revealed the disc like shape of the particles. From differential scanning calorimetry data it can be concluded that the particle core is in the crystalline state. Additionally it was proven that the particles are surrounded by a soft layer. Conclusions. Thus it is conceivable that the fast initial drug release during in vitro dissolution tests takes place by drug release of the outer non-crystalline layers of the particles. The following sustained drug release can be assigned to the predisolone release of the inner crystalline particle layers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1016042504830
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    In vitro nitrosation of ephedrine in the presence of cyclodextrins (1987)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 5 (1987), S. 621-624 
    Details
    ISSN: 1573-1111
    Schlagwort(e): Nitrosation reactions ; α-, β-, γ-cyclodextrin ; dimethyl-β-cyclodextrin ; ephedrine ; nitrosoephedrine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract β-, and γ-cyclodextrin and heptakis-2,6-di-O-methyl-β-cyclodextrin enhance the nitrosation rate of l-ephedrine if the nitrosation assay procedure (NAP test) is applied. During this reaction with β-cyclodextrin a solid inclusion compound of β-cyclodextrin andN-nitrosoephedrine precipitates. Solubilities and stabilities of inclusion compounds of the cyclodextrins with ephedrine and nitrosoephedrine, respectively, explain especially the catalytic effects of some cyclodextrins on ephedrine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00663002
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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