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  • 11
    Digitale Medien
    Digitale Medien
    Effect of naloxone administration upon responses of adrenal hormones to withdrawal from ethanol (1984)
    Springer
    Psychopharmacology 82 (1984), S. 181-184 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Corticosterone ; Adrenal catecholamine ; Ethanol ; Withdrawal ; Naloxone ; Stress ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Rats maintained on an ethanol-liquid diet developed physical dependence after 16 days. Activation of adrenocortical function and overactivity of the sympathoadrenal system were observed during withdrawal from ethanol. The opiate antagonist naloxone prevented the adrenomedullary response, and attenuated, though not significantly, the increases in serum corticosterone induced by ethanol deprivation. These findings suggest that endogenous opioid pathways may be involved in the ethanol-withdrawal syndrome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00427769
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  • 12
    Digitale Medien
    Digitale Medien
    Effects of adrenaline on the acquisition and maintenance of ethanol preference in a taste conditioning paradigm (1986)
    Springer
    Psychopharmacology 90 (1986), S. 336-340 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Adrenaline ; Taste paradigm ; Ethanol preference ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of subcutaneous adrenaline administration on preference for ethanol (2.5% solution) have been investigated, using a two-bottle choice situation. Administration of the amine (50 μg/kg) immediately after the conditioning session significantly attenuated ethanol preference. Adrenaline treatment (10, 50 or 100 μg/kg) prior to the first retention test induced a significant reduction in ethanol preference. When the amine was injected prior to conditioning only the dose of 100 μg/kg reduced later ethanol preference. Our results indicate that systemically administered adrenaline impairs the acquisition of preference to a weak ethanol solution. It is suggested that this effect of the amine may be linked to interference with consolidation of memory and retrieval processes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00179187
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  • 13
    Digitale Medien
    Digitale Medien
    Administration of leu-enkephalin impairs the acquisition of preference for ethanol (1990)
    Springer
    Psychopharmacology 100 (1990), S. 350-354 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Ethanol ; Opiates ; Leu-enkephalin ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of subcutaneous administration of leuenkephalin (LEU-E) (10, 100 and 300 µg/kg) and LEU-E (100 µg/kg) plus naloxone (2.5 mg/kg) on ethanol preference and fluid intake have been investigated in rats. Under our procedural conditions, rats develop ethanol preference through forced ethanol drinking (conditioning session). Preconditioning administration of LEU-E induced a reduction of later ethanol preference. Post-conditioning administration of LEU-E (10 and 100 µg/kg) also attenuated the development of ethanol preference. NX antagonized the effects of LEU-E on ethanol preference and fluid consumption in the two experimental procedures used, indicating an involvement of opioid receptors in the LEU-E-induced impairment of the acquisition of ethanol preference.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02244605
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