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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 64 (1995), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The weaver mutant mouse (wv/wv) has an ∼70% loss of nigrostriatal dopamine (DA) neurons, but the fractional DA release evoked by amphetamine (but not a high potassium level) has been shown to be greater from striatal slices of the weaver compared with +/+ mice. In the present work we tested the hypothesis that fractional DA release from weaver striatum would be greater when release was mediated by the DA transporter. Serotonin (5-HT)-stimulated fractional DA release was greater from weaver than from +/+ striatum. The release evoked by 5-HT in the presence of 10 µM nomifensine (an antagonist of the DA transporter) was less than in its absence, but the difference between weaver and +/+ striatum remained. In the presence of nomifensine, 1-(m-chlorophenyl)biguanide, classified as a 5-HT3 agonist, also induced a greater fractional release from weaver compared with +/+ striatum. When veratridine was used at a low concentration (1 µM), the fractional evoked release of DA was higher from the weaver in the presence and absence of nomifensine. These findings suggest that the reason for the difference in the responsiveness of the two genotypes to these release-inducing agents is not related to DA transporter function.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 57 (1991), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: : The weaver mutant mouse has a genetically determined defect in the nigrostriatal dopaminergic system. The present study was undertaken to test the hypothesis that in the weaver mutant mouse, striatal nerve terminals undergo compensatory changes in response to this deficiency. To test this hypothesis, we studied the basal and stimulated release of dopamine from striatal slices of weaver mutant mice and matched controls. By using a superfusion system and concentrating the superfusate by passage over alumina, resting dopamine release could be determined in the weaver mutant despite the fact that striatal tissue content of dopamine in these mice is reduced by 〉75% compared with control mice. Fractional resting release of dopamine in weaver striatal slices was significantly elevated compared with that in controls, suggesting that the release mechanisms in the weaver may be adapting to overcome the dopamine deficit. Potassium-evoked release (24 and 48 mM potassium) was not significantly different between the two genotypes. In contrast, amphetamine-evoked release (1 μM) was significantly greater in the weaver mice than in controls. In both genotypes, release evoked by amphetamine was completely inhibited by cocaine, implicating the dopamine uptake carrier in this release process. These findings suggest that fundamental differences in dopamine release mechanisms exist between weaver and control mice and support the hypothesis that compensatory mechanisms may develop in neurons in response to dopamine deficits.
    Materialart: Digitale Medien
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  • 3
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 4386-4396 
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 3705-3706 
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: We propose simple configurations to measure the thermoelectric power and the four-probe resistivity simultaneously for different types of samples.© 1998 American Institute of Physics.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 1211-1218 
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: In contact with an environment, a solid may gain or lose mass due to, for example, deposition or etching. As the reaction proceeds, the surface of the solid moves, either extending or receding. If the solid is under stress, the elastic energy adds to the driving force of the reaction, and may cause the surface to roughen. This phenomenon has recently led to a novel experimental technique to determine the stress state in a solid by using an atomic force microscope to scan the surface profiles before and after etching. Stress is also known to change the mobility of a reaction. By this mechanism, the stress may either roughen or stabilize a flat surface. This article describes a linear perturbation analysis of a three-dimensional solid surface evolving under stress, using a general kinetic law. It is found that when the reaction is near equilibrium, the stress effect on driving force dominates; when the reaction is far from equilibrium, the stress effect on mobility dominates. Under these two conditions, the surface profile spectra have different patterns and length scales. The implications for the stress measurement technique are discussed. It is suggested that the same experimental procedure be used to measure surface energy and activation strains. © 2000 American Institute of Physics.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 5424-5426 
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The isostructural uranium monopnictides and monochalcogenides have become prototype systems in actinide research with respect to their unusual magnetic properties. We have investigated the origins in the electronic structure of the variation in magnetic behavior as the degree of 5f-electron localization changes from localized to itinerant on going up the pnictogen or chalcogen column, thus decreasing the U-U separation. We have applied a synthesis of: (1) A phenomenological theory of orbitally driven magnetic ordering which includes both the hybridization-induced and the RKKY exchange interactions on an equal footing, and (2) Ab initio electronic structure calculations, based on the linear-muffin-tin-orbital method, allowing a first-principles evaluation of the parameters entering the model Hamiltonian. We have investigated systematically characteristic trends and changes of the 5f-state resonance width, the hybridization potential, and the hybridization-induced and RKKY exchange interactions with chemical environment, on going down the pnictogen or chalcogen column and on going from the weakly hybridizing pnictides to the more strongly hybridizing chalcogenides.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 71 (2000), S. 266-270 
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: We describe a technique for measuring the water vapor supersaturation of normal air over a temperature range of −40(approximately-less-than)T(approximately-less-than)0 °C. The measurements use an inexpensive commercial hygrometer which is based on a thin-film capacitive sensor. The time required for the sensor to reach equilibrium was found to increase exponentially with decreasing sensor temperature, exceeding 2 min for T=−30 °C; however, the water vapor sensitivity of the device remained high down to this temperature. After calibrating our measurement procedure, we found residual scatter in the data corresponding to an uncertainty in the absolute water vapor pressure of about ±15%. This scatter was due mainly to long-term drift, which appeared to be intrinsic to the capacitive thin-film sensor. The origin of this drift is not clear, but it effectively limits the applicability of this instrument for absolute measurements. We also found, however, that the high sensitivity of the thin-film sensor makes it rather well suited for differential measurements. By comparing supersaturated and saturated air at the same temperature we obtained a relative measurement uncertainty of about ±1.5%, an order of magnitude better than the absolute measurements. © 2000 American Institute of Physics.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 5326-5335 
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: Equations of state for hard sphere chain molecules are derived within the framework of second order perturbation theory of polymerization (TPT2). The present formulation differs from the original Wertheim's treatment by dealing with molecules with a fixed number of beads. However, the two versions yield very close numerical results for chains composed of freely jointed spheres, showing the insensitivity of the pressure of these fluids to polydispersity. The case of star-like molecules and chain mixtures is also considered. Theoretical predictions are compared to available simulation data, using recent results for the triplet correlation function for hard spheres in rolling contact. Some predictions for the pressure of freely rotating chains and that of trimers as a function of the bond angle are given.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 1158-1162 
    ISSN: 1089-7623
    Quelle: AIP Digital Archive
    Thema: Physik , Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Heterodyne detection of light scattered from capillary waves is used to study the surface properties of the air–liquid interface. A diffraction grating is employed to select a precise ripplon wave vector k and to provide a stable local oscillator field. The optics are designed to form a real image of the grating on the surface, thus allowing the measurements to be reproducible within 5%. The power spectrum detected in frequency domain is well fitted by a Lorentzian profile for the range of ripplon wave vectors 260≤k≤390 cm−1. The shape of the scattered spectra at each wave vector is corrected for the incident beam profile by effecting a convolution of the Lorentzian and Gaussian functional forms. The surface tensions and the kinematic viscosities of water, anisole, and ethanol are deduced from the ripplon dispersion relation corrected to the first order in damping, and found to be within 5% of the literature values. Thus we confirm the validity of approximations made for the instrumental function and the dispersion relation.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Journal of the American Chemical Society 106 (1984), S. 4419-4423 
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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