ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Biomaterials Center is composed of five groups and collaborate each other to examineinterdisciplinary fields of biomaterials. In the ceramics-based biomaterials research, we have beendeveloping three novel bone regeneration materials, i.e., high-porosity hydroxyapatite (HAp)ceramics with high-strength, guided bone regeneration (GBR) membranes and bone-likenanocomposite composed of HAp and collagen. The GBR membrane composed of β-tricalciumphosphate and biodegradable copolymer of lactide, glycolide and ε-caprolactone has thermoplastic,pH auto-adjustment and enough mechanical property to protect an invasion of surrounding tissues.With the membrane, bone defect up to 20 × 10 × 10 mm3 in length in mandibles and segmentalbone defect up to 20 mm in length in tibiae of beagles are regenerated without any additional bonefillers or cell transplantations. The bone-like nanocomposite is synthesized by a co-precipitation ofHAp and collagen via their self-organization. The dense composite has a half to quarter mechanicalstrength (40 MPa) to cortical bone and the porous one demonstrates sponge-like viscoelasticity.The composites implanted into bone are incorporated into bone remodeling metabolism like asautogenous bone graft, i.e., they are resorbed by osteolasts followed by osteogenesis by osteoblasts
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.277.pdf
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