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  • 11
    Electronic Resource
    Electronic Resource
    Trivalent behavior of palladium in silicon (1997)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 71 (1997), S. 1379-1381 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Palladium is known to exhibit an acceptor state at EC−0.22 eV in n-type Si and a donor state at EV+0.31 eV in p-type Si. We have identified a third level at EV+(0.140±0.005) eV and attribute it to the double donor state of substitutional Pd. The Pd level positions are very similar to the corresponding levels for Pt. The double donor states of both metals show an electric field dependence of the emission rates and a thermal activation of the hole capture cross sections. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.119899
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  • 12
    Electronic Resource
    Electronic Resource
    Intracellular Free Calcium Dynamics in Stretch-Injured Astrocytes (1998)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 70 (1998), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We have previously developed an in vitro model for traumatic brain injury that simulates a major component of in vivo trauma, that being tissue strain or stretch. We have validated our model by demonstrating that it produces many of the posttraumatic responses observed in vivo. Sustained elevation of the intracellular free calcium concentration ([Ca2+]i) has been hypothesized to be a primary biochemical mechanism inducing cell dysfunction after trauma. In the present report, we have examined this hypothesis in astrocytes using our in vitro injury model and fura-2 microphotometry. Our results indicate that astrocyte [Ca2+]i is rapidly elevated after stretch injury, the magnitude of which is proportional to the degree of injury. However, the injury-induced [Ca2+]i elevation is not sustained and returns to near-basal levels by 15 min postinjury and to basal levels between 3 and 24 h after injury. Although basal [Ca2+]i returns to normal after injury, we have identified persistent injury-induced alterations in calcium-mediated signal transduction pathways. We report here, for the first time, that traumatic stretch injury causes release of calcium from inositol trisphosphate-sensitive intracellular calcium stores and may uncouple the stores from participation in metabotropic glutamate receptor-mediated signal transduction events. We found that for a prolonged period after trauma astrocytes no longer respond to thapsigargin, glutamate, or the inositol trisphosphate-linked metabotropic glutamate receptor agonist trans-(1S,3R)-1-amino-1,3-cyclopentanedicarboxylic acid with an elevation in [Ca2+]i. We hypothesize that changes in calcium-mediated signaling pathways, rather than an absolute elevation in [Ca2+]i, is responsible for some of the pathological consequences of traumatic brain injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1998.70062377.x
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  • 13
    Electronic Resource
    Electronic Resource
    The shape of the ground and lowest two excited states of H2NO (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 103 (1995), S. 274-280 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The structure of the ground and lowest two excited states of H2NO have been determined in large scale configuration interaction calculations using a multiconfiguration self-consistent description of the molecular orbitals. These treatments are based on a systematic building of the correlation contribution which has been designed to account for the characteristics of the nitroxide group. This approach shows that the aminoxyl functional group is more than a three electron group shared by two atoms, but, in fact, a nine electron entity. Our best estimate of the geometry of the ground electronic state, obtained after second-order configuration interaction using a large basis of atomic natural orbitals, is pyramidal. However, since the potential depth between 0° and 40° is lower or of the same order of magnitude as the estimated inversion frequency, the conclusion that this molecule behaves like a planar system is totally justified. The structure of the excited (n−π*) and (π−π*) states have been determined and the transitions energies are in accordance with the experimental results on the highly substituted stable nitroxide radicals. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.469640
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  • 14
    Electronic Resource
    Electronic Resource
    Absence of linkage between 5q markers and serum IgE levels in four large atopic families (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Both genetic and environmental influences have been suggested to control the immunoglobulin (Ig)E response to allergens and, as a result, provide susceptibility to atopic disease. Two recent reports suggested that a major gene controlling basal IgE levels in humans was transmitted in a pattern consistent with autosomal recessive inheritance and was located on the long arm of chromosome 5 in the interleukin (IL)-4 gene complex.Objective The purpose of this report is to evaluate evidence for linkage of IgE with polymorphic genetic markers in the candidate region of 5q in four large pedigrees originally selected for studies of atopy.Method Four large, highly characterized pedigrees in which IgE levels had been determined and genotypes at markers in the 5q candidate region were evaluated using both lod score and sib pair methods of analysis.Results In these pedigrees, we reject close to moderate hnkage (up to 5 cM) of an IgE locus with markers on 5q.Conclusion The genetic aspects of IgE regulation and its role in atopy remain controversial. The data suggest that should major genes be involved in the inheritance of atopy susceptibility, they are likely to be multiple in number and likely to involve interaction with other (exogenous) environmental exposures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1996.tb00623.x
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  • 15
    Electronic Resource
    Electronic Resource
    Benzoyl peroxide as a contact allergen in adhesive tape (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 41 (1999), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1999.tb06146.x
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  • 16
    Electronic Resource
    Electronic Resource
    Qualitätssicherung bei der Extremitätenphlebographie (1998)
    Springer
    Der Radiologe 38 (1998), S. 578-585 
    Details
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Phlebographie ; Doppler- und Duplexsonographie ; Extremitätenvenen ; Qualitätssicherung ; Key words Phlebography ; Duplex-ultrasound ; Extremity veins ; Quality standards
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary By interdisciplinary cooperation with the German Societies for Angiology, Phlebology and Vascular Surgery, recommendations have been worked out which address the indication of phlebography of the veins of the extremities and which define the quality standards of phlebographic techniques. The specific clinical questions in varicose syndrome, acute thrombosis and postthrombotic syndrome have to be answered by employing adequate phlebographic technique, documentation, and description of relevant morphologic and functional findings.
    Notes: Zusammenfassung In Zusammenarbeit mit den Fachgesellschaften Deutsche Gesellschaft für Angiologie, Deutsche Gesellschaft für Phlebologie und Deutsche Gesellschaft für Gefäßchirurgie wurden Empfehlungen zur Indikationsstellung, Untersuchungstechnik und Qualitätssicherung der Extremitätenphlebographie erstellt. Für die speziellen klinischen Fragestellungen beim Varikosesyndrom, bei der akuten Phlebothrombose und beim Postthrombotischen Syndrom werden die Qualitätsmerkmale für die Dokumentation und Befundung nach morphologischen und funktionellen Gesichtspunkten tabellarisch zusammengefaßt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001170050395
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  • 17
    Electronic Resource
    Electronic Resource
    MRI assessment of cerebral blood volume in patients with brain infarcts (1998)
    Springer
    Neuroradiology 40 (1998), S. 496-502 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Perfusion studies ; Dynamic contrast-enhanced imaging ; Cerebral blood volume ; Brain infarcts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract MRI perfusion studies have focussed mainly on acute ischaemia and characterisation in ischaemia. Our purpose was to analyse regional brain haemodynamic information in acute, subacute, and chronic ischaemia. We performed 16 examinations of 11 patients on a 1.5 T MR images. Conventional and dynamic contrast-enhanced imaging were employed in all examinations. For the dynamic susceptibility sequences, a bolus (0.2 mmol/kg) of gadopentetate dimeglumine was injected. Reconstructed regional relative cerebral blood volume (rCBV) maps, bolus maps, and conventional images were analysed by consensus reading. In all examinations decreases in rCBV were observed in the lesions. The distribution of regional rCBV in lesions was heterogeneous. The rCBV of the periphery of the lesions was higher than that at their center. There was a correlation between the time since onset and abnormalities on the rCBV map and T2-weighted images (T2WI). In the early stage of acute stroke, the abnormalities tended to be larger on the rCBV than on T2WI. Many patterns of bolus passage were observed in ischaemic regions. rCBV maps provide additional haemodynamic information in patients with brain infarcts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002340050632
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  • 18
    Electronic Resource
    Electronic Resource
    Response of mud crab (Panopeus herbstii) megalopae to cues from adult habitat (1996)
    Springer
    Marine biology 126 (1996), S. 655-661 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract During the summer of 1995, we investigated the response of mud crab megalopae (Panopeus herbstii Milne-Edwards) to cues associated with adult habitat. Natural rock/shell substratum and the rock-associated seaweed, Fucus vesiculosus L., both induced metamorphosis of competent megalopae; natural sand substratum did not induce metamorphosis. Structural mimics of preferred substrata induced metamorphosis only when covered with natural biofilm. Clean mimics did not induce metamorphosis. Water-soluble exudates from preferred substrata showed weak induction of metamorphosis. Exudates from adult P. herbstii elicited a similar weak response. Exudates from another species of crab and from two fish predators did not induce metamorphosis. We conclude that water-soluble cues associated with major components of preferred adult habitat induce the metamorphic molt of P. herbstii megalopae. The three-dimensional structure of the substratum is not important in induction of metamorphosis, but the biofilm associated with preferred substratum plays a critical role. It is not clear whether the biofilm produces the water-soluble cue or simply provides a tactile stimulus that works in conjunction with the soluble cue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351332
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  • 19
    Electronic Resource
    Electronic Resource
    Internal anal sphincter repair (1997)
    Springer
    International journal of colorectal disease 12 (1997), S. 243-245 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Les résultats de la réparation isolée du sphincter interne ont étéévalués chez cinq patients présentant une incontinence anale persistante après un geste chirurgical ayant lésé le sphincter interne. Tous présentaient une incontinence passive pour les solides et les liquides. Les symptômes, les résultats de la manométrie ano-rectale et de l'échographie endo-anale ont étéévalués avant et après correction chirurgicale. Après l'intervention, trois patients se disent améliorés mais présentent toujours des symptômes persistants; aucun patient n'a retrouvé une continence complète. Trois patients présentent une augmentation de la pression de repos et de la pression de contraction maxi-male mais chez un seul patient, ces valeurs sont dans la limite de la norme. En post-opératoire, l'échographie endo-anale montre une persistance du défect du sphincter interne chez tous les cas et dans deux, cet examen met en évidence une lésion méconnue du sphincter externe. Bien que quelques patients se sentent améliorés, les résultats cliniques manométriques et radiologiques après réparation du sphincter anal interne sont décevants.
    Notes: Abstract. The results of repair to the internal and sphincter alone has been evaluated in five patients with persistent anal incontinence following surgery which affected the internal anal sphincter. All had passive incontinence for solid or liquid stool. Symptoms, anorectal manometry, and anal endosonography were evaluated before and after surgery. After surgery three patients felt improved but had still persistent symptoms, and no patients achieved full continence. Three patients showed an increased maximal and resting pressure, but only one of them was within the normal range. Post operatively, all the anal ultrasound scans showed a persistent internal sphincter defect, and two showed an unsuspected external anal sphincter defect. Although some patients felt symptomatically improved, the overall clinical, manometric and radiological findings after internal and sphincter repair were disappointing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050098
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  • 20
    Electronic Resource
    Electronic Resource
    Analysis of RNA sequence structure maps by exhaustive enumeration II. Structures of neutral networks and shape space covering (1996)
    Springer
    Monatshefte für Chemie 127 (1996), S. 375-389 
    Details
    ISSN: 1434-4475
    Keywords: Neutral networks ; Percolation of sequence space ; RNA folding ; RNA secondary structures ; Shape space covering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Beziehungen zwischen RNA-Sequenzen und ihren Sekundärstrukturen werden durch vollständiges Falten allerGC- undAU-Sequenzen mit Kettenlängen bis zun=30 untersucht. Die aus der Informatik bekannte Technik derTries wird zur ökonomischen Datenspeicherung und für rasches Retrieval der gespeicherten Information angewendet. Die berechneten Strukturdaten werden durch vollständiges Abzählen ausgewertet. Sie dienen unter anderem als eine exakte Referenz zum Testen analytischer Resultate aus mathematischen Modellen sowie zur Überprüfung der Ergebnisse statistischer Probennahmen. Verschiedene neuartige Konzepte zur Behandlung der Zusammenhänge zwischen RNA-Sequenzen und Sekundärstrukturen wurden anhand der gewonnenen Daten eingehend untersucht. Unter ihnen befinden sich die Struktur derneutralen Netzwerke (die Gesamtheit der RNA-Sequenzen, die eine bestimmte Struktur ausbilden), diePerkolation des Sequenzraumes durch neutrale Netzwerke sowie das Prinzip derErfassung des Strukturraumes durch einen kleinen Ausschnitt des Sequenzraumes. Die durch vollständiges Abzählen erhaltenen Daten werden mit den analytischen Ergebnissen eines auf der Theorie der Zufallsgraphen aufbauenden Modells verglichen. Dieses Modell gibt die generischen Eigenschaften von Sequenz-Struktur-Relationen wieder, welche lediglich aus der Existenz einer Paarungslogik resultieren. Differenzen zwischen den numerischen und den analytischen Resultaten können als Konsequenzen der spezifischen biophysikalischen Eigenschaften von RNA-Molekülen interpretiert werden.
    Notes: Summary The relations between RNA sequences and secondary structures are investigated by exhaustive folding of allGC andAU sequences with chain lengths up to 30. The technique oftries is used for economic data storage and fast retrieval of information. The computed structural data are evaluated through exhaustive enumeration and used as an exact reference for testing analytical results derived from mathematical models and sampling based on statistical methods. Several new concepts of RNA sequence to secondary structure mappings are investigated, among them the structure ofneutral networks (being sets of RNA sequences folding into the same structure),percolation of sequence space by neutral networks, and the principle ofshape space covering. The data of exhaustive enumeration are compared to the analytical results of arandom graph model that reveals the generic properties of sequence to structure mappings based on some base pairing logic. The differences between the numerical and the analytical results are interpreted in terms of specific biophysical properties of RNA molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00810882
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