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  • 11
    Electronic Resource
    Electronic Resource
    An adoptive immunotherapy of patients with medulloblastoma by lymphokine-activated killer cells (LAK) (1988)
    Springer
    Acta neurochirurgica 94 (1988), S. 47-52 
    Details
    ISSN: 0942-0940
    Keywords: Brain neoplasms ; medulloblastoma ; lymphokine-activated killer (LAK) cells ; adoptive immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An adoptive immunotherapy of 6 patients with medulloblastoma by lymphokine-activated killer (LAK) cells is described. They were from 2 to 9 years in age and had cerebrospinal fluid (CSF) dissemination of the tumours. All patients underwent the whole-neuraxis irradiation and chemotherapy. After the usual treatments, they were submitted to an adoptive transfer of one-haplotype identical LAK cells. The LAK cells were induced from peripheral blood lymphocytes (PBL) of their relatives with human recombinant interleukin-2 (rIL-2). 3–15×109 LAK cells were transferred intrathecally in 2–3 months. In 3 of 6 patients, neurological signs were improved and malignant cells had never been detected on CSF cytology after the adoptive immunotherapy. One among these 3 patients showed complete response in 20 months. Thus, this is an attractive approach for the treatment of medulloblastoma with CSF dissemination of the tumour which current therapeutic intervention can not cure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406615
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  • 12
    Electronic Resource
    Electronic Resource
    Hydroxyproline concentration in soluble and insoluble material from serum treated with trichloroacetic acid in postpartum mice (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 819-820 
    Details
    ISSN: 1420-9071
    Keywords: Hydroxyproline concentration ; serum ; trichloroacetic acid ; postpartum ; mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The hydroxyproline concentration in both the soluble and insoluble material from trichloroacetic acid-treated serum from postpartum mice was determined. The hydroxyproline concentration in the insoluble material increased, but that in the soluble material did not increase during the uterine involuting period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01941536
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  • 13
    Electronic Resource
    Electronic Resource
    Ontogeny of cholecystokinin-8 and glutamic acid decarboxylase in cerebral neocortex of macaque monkey (1989)
    Springer
    Experimental brain research 74 (1989), S. 249-255 
    Details
    ISSN: 1432-1106
    Keywords: Cholecystokinin-8 ; Glutamic acid de-carboxylase ; Cerebral cortex ; Primate ; Ontogeny
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concentration of cholecystokinin-8 and the activity of glutamic acid decarboxylase were determined in the various cerebral cortical subdivisions of Japanese monkey (Macaca fuscata fuscata) at three different ages (embryonic 4 months, full-term and adult). The CCK-8 immunoreactive material extracted with 90% methanol from the cerebral cortex of the adult and foetal monkey were shown to be identical with synthetic cholecystokinin-8 by the criterion of co-elution on gel filtration chromatography (Sephadex G-50). The peptide concentration increased dramatically by about 30–80 fold (in terms of protein) and 17–28 fold (in terms of wet weight) between embryonic 4-month-old and full-term monkeys, while the level decreased 1/6–1/16 (protein) and 1/4–1/10 (wet weight) between full-term and adult monkeys. In adults, the highest levels of the peptide was observed in the association cortex, orbital prefrontal cortex and posterior parietal cortex. Glutamic acid decarboxylase activity, on the other hand, gradually increased about 4–10 fold (protein) between embryonic 4-month-old and adult animals and there was little variation in the increase rate among the cerebral subdivisions. In contrast to cholecystokinin-8, no reduction in the enzyme activity occurred between full-term and adult animals. The high level of cholecystokinin-8 in the embryonic period suggests that the peptide may participate in the regulation of the development of primate cerebral cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00248857
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  • 14
    Electronic Resource
    Electronic Resource
    Multiple associated endocrine abnormalities in a patient with pseudohypoparathyroidism type 1a (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 536-538 
    Details
    ISSN: 1432-1076
    Keywords: Pseudohypoparathyroidism ; Hypothyroidism ; Neonatal mass screening ; Bone age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A girl with type 1a pseudohypoparathyroidism (PHP) presented several hormonal abnormalities. Although she had eluded neonatal thyroid screening, she was diagnosed as having hypothyroidism at the age of 5 months. Thereafter, a diagnosis of PHP was made on the basis of skeletal features of Albright osteodystrophy and lack of both cyclic adenosine monophosphate (c-AMP) and phosphaturic responses after parathyroid hormone (PTH) infusion. The basal levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were higher than normal and showed exaggerated responses to luteinizing hormone-releasing hormone (LH-RH). There was no growth hormone (GH) response to arginine infusion, and the prolactin (PRL) response after thyrotropin-releasing hormone (TRH) infusion was also impaired. The stimulating guanine nucleotide-binding protein (Ns) activity of the erythrocytes was reduced to 66.9%. The skeletal age was not delayed at the age of 5 months in spite of the hypothyroid state, and it advanced following thyroxine and vitamin D treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441985
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  • 15
    Electronic Resource
    Electronic Resource
    Characteristics of βA chromosome haplotypes in Japanese (1987)
    Springer
    Biochemical genetics 25 (1987), S. 197-203 
    Details
    ISSN: 1573-4927
    Keywords: DNA ; polymorphism ; β-globin gene cluster ; Japanese ; AγT-globin gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract DNA polymorphism patterns linked to the βA-globin gene were analyzed in healthy Japanese using four different restriction endonucleases. The chromosomes with the βA-globin gene were mapped through an evaluation of the presence of seven different restriction sites (HincII 5′ to ε; HindIII in Gγ and Aγ; HincII in, and 3′ to, ψβ1; AvaII in β; Bam-HI 3′ to β). Among 36 chromosomes analyzed, 20 chromosomes had a haplotype of [+−−−−−+]. Among 55 individuals examined, 7 possessed a homozygous haplotye of [+−−−−−+]. All Japanese with the AγT-globin gene had a subhaplotype of [−++−+] 5′ to the δ-globin gene. Their major haplotypes were [−++−+−+] and [−++−++−]. It was expected that the presence of the AγT-globin gene in Japanese may be deduced from subhaplotypes 5′ to the δ-globin gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499313
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  • 16
    Electronic Resource
    Electronic Resource
    Magnetoresistance oscillations in aluminum near the [001] axis (1979)
    Springer
    Journal of low temperature physics 35 (1979), S. 41-52 
    Details
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Quantum oscillations in the transverse magnetoresistance of aluminum single crystals were measured at 4.2 K in fields near the [001] direction of up to 50 kOe. The rotation diagrams around two axes, the current axis (θ-rotation) and normal to it (Φ-rotation), were investigated by directly measuring the amplitude of oscillations in steps of about 0.1†. As the field was tilted from [001] by about 2.5† in the Φ plane, the separation of double maxima in the θ rotation diagram changed from 0.8† to 5.0† for the [010] current samples, and from 2.8° to 5.6° for the [110]current samples, and the amplitude of oscillation decreased. A fast oscillation, which had not been observed in conventional dc magnetoresistance measurements, was simultaneously detected near the field direction where the β-orbit oscillations have a maximum amplitude.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121721
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  • 17
    Electronic Resource
    Electronic Resource
    Schwingungsrelaxation von glasigen Polymeren (1975)
    Springer
    Colloid & polymer science 253 (1975), S. 350-350 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02352221
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  • 18
    Electronic Resource
    Electronic Resource
    On one pion exchange potential with quark exchange in the resonating group method (1985)
    Springer
    The European physical journal 320 (1985), S. 609-612 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The effect of quark exchange between different nucleons on the one pion exchange potential is studied in the framework of the resonating group method. The calculated phase shifts including the one pion exchange potential with quark exchange in addition to the one gluon plusσ meson exchange are shown to be consistent with experiments. Especially thep-wave phase shifts are improved by taking into account the quark exchange on the one pion exchange potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411860
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  • 19
    Electronic Resource
    Electronic Resource
    The effect of tensor correlations on isovector operators (1976)
    Springer
    The European physical journal 278 (1976), S. 201-203 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Very simple relations between renormalization factors and corrections to the GT-typeΒ-decay operator, isovector magnetic moment and coulomb energy differences between mirror nuclei due to tensor correlations are obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01437776
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  • 20
    Electronic Resource
    Electronic Resource
    Crystalline barrier oxide films formed on aluminium in an aqueous solution of ammonium dihydrogen phosphate (1986)
    Springer
    Journal of materials science 5 (1986), S. 543-544 
    Details
    ISSN: 1573-4811
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728685
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