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  • 11
    ISSN: 1432-2072
    Keywords: Uptake ; Platelets ; 5-Hydroxytryptamine ; Dopamine ; Inhibition ; Protriptyline ; Clomipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of protriptyline and clomipramine, at concentrations of 10−7 M to 10−4 M, were studied in vitro on the uptake of 5-hydroxytryptamine and dopamine uptake in human platelet-rich plasma. It was found that the tertiary amine, clomipramine, was a more potent inhibitor of 5-hydroxytryptamine uptake than the secondary amine, protriptyline. The activity of both compounds was competitive but it was thought unlikely that they acted through tryptamine receptor sites as methysergide 2.5×10−8 M had very little effect on 5-hydroxytryptamine uptake. Neither tricyclic antidepressant had any marked effect on dopamine uptake.
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1432-2072
    Keywords: Beta-adrenoceptor blockade ; CNS function tests
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of oral oxprenolol (480 mg) and lorazepam (2 mg) on skin conductance, reaction time, critical flicker frequency and self-rating visual analogue scales for anxiety, sedation and concentration were investigated in 6 healthy male volunteers. Oxprenolol exerted a central action similar to lorazepam as shown by a significant lowering of skin conductance and decrease in the number of spontaneous fluctuations during stress, impaired critical flicker frequency and decrease in alertness with reduced concentration.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 19 (1976), S. 381-400 
    ISSN: 1573-2878
    Keywords: Variable metric methods ; optimization theorems ; Hilbert spaces ; control theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper is concerned with some of the most powerful methods of minimizing functionals on Hilbert space. It is established that certain classes of these methods are equivalent and their convergence is proved for certain nonquadratic functionals on a Hilbert space. A computational study of these methods applied to a control problem is also included with particular reference to the equivalence of methods mentioned above.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 21 (1977), S. 199-211 
    ISSN: 1573-2878
    Keywords: Variable-metric methods ; optimization theorems ; Hilbert spaces ; control theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this paper, the Hilbert-space analogue of a result of Huang, that all the methods in the Huang class generate the same sequence of points when applied to a quadratic functional with exact linear searches, is established. The convergence of a class of direct prediction methods based on some work of Dixon is then proved, and these methods are then applied to some control problems. Their performance is found to be comparable with methods involving exact linear searches.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 22 (1977), S. 399-415 
    ISSN: 1573-2878
    Keywords: Variable-metric methods ; optimization theorems ; Hilbert spaces ; control theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this paper, the convergence of variable-metric methods without line searches (direct prediction methods) applied to quadratic functionals on a Hilbert space is established. The methods are then applied to certain control problems with both free endpoints and fixed endpoints. Computational results are reported and compared with earlier results. The methods discussed here are found to compare favorably with earlier methods involving line searches and with other direct prediction quasi-Newton methods.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 2 (1977), S. 81-84 
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An improved gas comparison pycnometer has been developed, based on precise differential pressure measurements coupled with a sample volume compensator. Using helium gas, volumes of solid and powdered explosives can be measured to a precision approaching one part in lo4. Coupled with a precise mass measurement, these volumes allow densities with an uncertainty of ∼± 0.002 g/ml to be inferred. Measurements performed on various explosives have allowed assessment of the purity and homogeneity of individual samples. It is also possible to infer void percentage or porosity in pressed explosive pellets.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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