ISSN:
1432-2072
Keywords:
Tandamine
;
Tyramine pressor response
;
Anticholinergic
;
Appetite
;
Sedation
;
Depression
;
Platelet
;
Plasma concentration
;
Monoamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426603
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